Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke
Introduction: The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0-5) in the extended time window outside of trial settings remains unclear. We analyzed the effect of EVT among these stroke patients in real-world settings. - Patients and methods: The CT...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 17, 2024
|
| In: |
European stroke journal
Year: 2024, Jahrgang: 9, Heft: 4, Pages: 907-917 |
| ISSN: | 2396-9881 |
| DOI: | 10.1177/23969873241249406 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/23969873241249406
|
| Verfasserangaben: | Adnan Mujanovic, Daniel Strbian, Jelle Demeestere, João Pedro Marto, Volker Puetz, Raul G Nogueira, Mohamad Abdalkader, Simon Nagel, Jean Raymond, Marc Ribo, Patrik Michel, Shinichi Yoshimura, Osama O Zaidat, Simon Winzer, Santiago Ortega-Gutierrez, Sunil A Sheth, James E Siegler, Anne Dusart, Diogo C Haussen, Hilde Henon, Bettina L Serrallach, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olive-Gadea, Ajit S Puri, Nobuyuki Sakai, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Zaidi, Tomas Dobrocky, Nicolas Martinez-Majander, Stefania Nannoni, Flavio Bellante, Aaron Rodriguez-Calienes, Sergio Salazar-Marioni, Pekka Virtanen, Daniel PO Kaiser, Rita Ventura, Jessica Jesser, Alicia C Castonguay, Muhammad M Qureshi, Hesham E Masoud, Milagros Galecio-Castillo, Manuel Requena, Riikka Lauha, Wei Hu, Eugene Lin, Zhongrong Miao, Daniel Roy, Hiroshi Yamagami, David J Seiffge, Davide Strambo, Peter A Ringleb, Robin Lemmens, Urs Fischer, Thanh N Nguyen, and Johannes Kaesmacher |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1910569836 | ||
| 003 | DE-627 | ||
| 005 | 20250716213506.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241202s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/23969873241249406 |2 doi | |
| 035 | |a (DE-627)1910569836 | ||
| 035 | |a (DE-599)KXP1910569836 | ||
| 035 | |a (OCoLC)1528014374 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mujanović, Adnan |d 1996- |e VerfasserIn |0 (DE-588)1278378030 |0 (DE-627)1831244292 |4 aut | |
| 245 | 1 | 0 | |a Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke |c Adnan Mujanovic, Daniel Strbian, Jelle Demeestere, João Pedro Marto, Volker Puetz, Raul G Nogueira, Mohamad Abdalkader, Simon Nagel, Jean Raymond, Marc Ribo, Patrik Michel, Shinichi Yoshimura, Osama O Zaidat, Simon Winzer, Santiago Ortega-Gutierrez, Sunil A Sheth, James E Siegler, Anne Dusart, Diogo C Haussen, Hilde Henon, Bettina L Serrallach, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olive-Gadea, Ajit S Puri, Nobuyuki Sakai, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Zaidi, Tomas Dobrocky, Nicolas Martinez-Majander, Stefania Nannoni, Flavio Bellante, Aaron Rodriguez-Calienes, Sergio Salazar-Marioni, Pekka Virtanen, Daniel PO Kaiser, Rita Ventura, Jessica Jesser, Alicia C Castonguay, Muhammad M Qureshi, Hesham E Masoud, Milagros Galecio-Castillo, Manuel Requena, Riikka Lauha, Wei Hu, Eugene Lin, Zhongrong Miao, Daniel Roy, Hiroshi Yamagami, David J Seiffge, Davide Strambo, Peter A Ringleb, Robin Lemmens, Urs Fischer, Thanh N Nguyen, and Johannes Kaesmacher |
| 264 | 1 | |c May 17, 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.12.2024 | ||
| 520 | |a Introduction: The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0-5) in the extended time window outside of trial settings remains unclear. We analyzed the effect of EVT among these stroke patients in real-world settings. - Patients and methods: The CT for Late Endovascular Reperfusion (CLEAR) study recruited patients from 66 centers in 10 countries between 01/2014 and 05/2022. The extended time-window was defined as 6-24 h from last-seen-well to treatment. The primary outcome was shift of the 3-month modified Rankin scale (mRS) score. Safety outcomes included symptomatic intracranial hemorrhage (sICH) and mortality. Outcomes were analyzed with ordinal and logistic regressions. - Results: Among 5098 screened patients, 2451 were included in the analysis (median age 73, 55% women). Of patients with ASPECTS 0-5 (n = 310), receiving EVT (n = 209/310) was associated with lower 3-month mRS when compared to medical management (median 4 IQR 3-6 vs 6 IQR 4-6; aOR 0.4, 95% CI 0.2-0.7). Patients undergoing EVT had higher sICH (11.2% vs 4.0%; aOR 4.1, 95% CI 1.2-18.8) and lower mortality (31.6% vs 58.4%, aOR 0.4; 95% CI 0.2-0.9) compared to medically managed patients. The relative benefit of EVT was comparable between patients with ASPECTS 0 and 5 and 6-10 in the extended time window (interaction aOR 0.9; 95% CI 0.5-1.7). - Conclusion: In the extended time window, patients with ASPECTS 0-5 may have preserved relative treatment benefit of EVT compared to patients with ASPECTS 6-10. These findings are in line with recent trials showing benefit of EVT among real-world patients with large ischemic core in the extended time window. - Trial registration number: clinicaltrials.gov; Unique identifier: NCT04096248 | ||
| 700 | 1 | |a Strbian, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Demeestere, Jelle |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marto, João Pedro |e VerfasserIn |4 aut | |
| 700 | 1 | |a Puetz, Volker |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nogueira, Raul G |e VerfasserIn |4 aut | |
| 700 | 1 | |a Abdalkader, Mohamad |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nagel, Simon |d 1974- |e VerfasserIn |0 (DE-588)129036072 |0 (DE-627)38788775X |0 (DE-576)297460218 |4 aut | |
| 700 | 1 | |a Raymond, Jean |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ribo, Marc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Michel, Patrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yoshimura, Shinichi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zaidat, Osama O |e VerfasserIn |4 aut | |
| 700 | 1 | |a Winzer, Simon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ortega-Gutierrez, Santiago |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sheth, Sunil A |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siegler, James E |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dusart, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haussen, Diogo C |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henon, Hilde |e VerfasserIn |4 aut | |
| 700 | 1 | |a Serrallach, Bettina L |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mohammaden, Mahmoud H |e VerfasserIn |4 aut | |
| 700 | 1 | |a Möhlenbruch, Markus Alfred |d 1979- |e VerfasserIn |0 (DE-588)137693591 |0 (DE-627)594845041 |0 (DE-576)304845655 |4 aut | |
| 700 | 1 | |a Olive-Gadea, Marta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Puri, Ajit S |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sakai, Nobuyuki |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klein, Piers |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tomppo, Liisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caparros, Francois |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ramos, João Nuno |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jumaa, Mouhammad |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zaidi, Syed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dobrocky, Tomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinez-Majander, Nicolas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nannoni, Stefania |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bellante, Flavio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rodriguez-Calienes, Aaron |e VerfasserIn |4 aut | |
| 700 | 1 | |a Salazar-Marioni, Sergio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Virtanen, Pekka |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaiser, Daniel PO |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ventura, Rita |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jesser, Jessica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Castonguay, Alicia C |e VerfasserIn |4 aut | |
| 700 | 1 | |a Qureshi, Muhammad M |e VerfasserIn |4 aut | |
| 700 | 1 | |a Masoud, Hesham E |e VerfasserIn |4 aut | |
| 700 | 1 | |a Galecio-Castillo, Milagros |e VerfasserIn |4 aut | |
| 700 | 1 | |a Requena, Manuel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lauha, Riikka |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hu, Wei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lin, Eugene |e VerfasserIn |4 aut | |
| 700 | 1 | |a Miao, Zhongrong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Roy, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yamagami, Hiroshi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seiffge, David J |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strambo, Davide |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ringleb, Peter A |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lemmens, Robin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fischer, Urs |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nguyen, Thanh N |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaesmacher, Johannes |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European stroke journal |d London : Sage Publishing, 2016 |g 9(2024), 4 vom: Mai, Seite 907-917 |h Online-Ressource |w (DE-627)856122106 |w (DE-600)2851287-X |w (DE-576)462988643 |x 2396-9881 |7 nnas |a Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke |
| 773 | 1 | 8 | |g volume:9 |g year:2024 |g number:4 |g month:05 |g pages:907-917 |g extent:11 |a Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke |
| 856 | 4 | 0 | |u https://doi.org/10.1177/23969873241249406 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241202 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 137693591 |a Möhlenbruch, Markus Alfred |m 137693591:Möhlenbruch, Markus Alfred |d 910000 |d 911100 |d 50000 |e 910000PM137693591 |e 911100PM137693591 |e 50000PM137693591 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 23 | ||
| 998 | |g 129036072 |a Nagel, Simon |m 129036072:Nagel, Simon |d 910000 |d 911100 |d 50000 |e 910000PN129036072 |e 911100PN129036072 |e 50000PN129036072 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 8 | ||
| 999 | |a KXP-PPN1910569836 |e 4629676643 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"name":{"displayForm":["Adnan Mujanovic, Daniel Strbian, Jelle Demeestere, João Pedro Marto, Volker Puetz, Raul G Nogueira, Mohamad Abdalkader, Simon Nagel, Jean Raymond, Marc Ribo, Patrik Michel, Shinichi Yoshimura, Osama O Zaidat, Simon Winzer, Santiago Ortega-Gutierrez, Sunil A Sheth, James E Siegler, Anne Dusart, Diogo C Haussen, Hilde Henon, Bettina L Serrallach, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olive-Gadea, Ajit S Puri, Nobuyuki Sakai, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Zaidi, Tomas Dobrocky, Nicolas Martinez-Majander, Stefania Nannoni, Flavio Bellante, Aaron Rodriguez-Calienes, Sergio Salazar-Marioni, Pekka Virtanen, Daniel PO Kaiser, Rita Ventura, Jessica Jesser, Alicia C Castonguay, Muhammad M Qureshi, Hesham E Masoud, Milagros Galecio-Castillo, Manuel Requena, Riikka Lauha, Wei Hu, Eugene Lin, Zhongrong Miao, Daniel Roy, Hiroshi Yamagami, David J Seiffge, Davide Strambo, Peter A Ringleb, Robin Lemmens, Urs Fischer, Thanh N Nguyen, and Johannes Kaesmacher"]},"person":[{"given":"Adnan","display":"Mujanović, Adnan","family":"Mujanović","role":"aut"},{"role":"aut","family":"Strbian","display":"Strbian, Daniel","given":"Daniel"},{"given":"Jelle","display":"Demeestere, Jelle","family":"Demeestere","role":"aut"},{"given":"João Pedro","display":"Marto, João Pedro","family":"Marto","role":"aut"},{"family":"Puetz","role":"aut","display":"Puetz, Volker","given":"Volker"},{"display":"Nogueira, Raul G","given":"Raul G","family":"Nogueira","role":"aut"},{"family":"Abdalkader","role":"aut","given":"Mohamad","display":"Abdalkader, Mohamad"},{"display":"Nagel, Simon","given":"Simon","family":"Nagel","role":"aut"},{"role":"aut","family":"Raymond","display":"Raymond, Jean","given":"Jean"},{"role":"aut","family":"Ribo","given":"Marc","display":"Ribo, Marc"},{"family":"Michel","role":"aut","given":"Patrik","display":"Michel, Patrik"},{"family":"Yoshimura","role":"aut","display":"Yoshimura, Shinichi","given":"Shinichi"},{"family":"Zaidat","role":"aut","display":"Zaidat, Osama O","given":"Osama O"},{"family":"Winzer","role":"aut","display":"Winzer, Simon","given":"Simon"},{"family":"Ortega-Gutierrez","role":"aut","given":"Santiago","display":"Ortega-Gutierrez, Santiago"},{"role":"aut","family":"Sheth","display":"Sheth, Sunil A","given":"Sunil A"},{"family":"Siegler","role":"aut","display":"Siegler, James E","given":"James E"},{"display":"Dusart, Anne","given":"Anne","role":"aut","family":"Dusart"},{"display":"Haussen, Diogo C","given":"Diogo C","family":"Haussen","role":"aut"},{"role":"aut","family":"Henon","given":"Hilde","display":"Henon, Hilde"},{"family":"Serrallach","role":"aut","display":"Serrallach, Bettina L","given":"Bettina L"},{"role":"aut","family":"Mohammaden","given":"Mahmoud H","display":"Mohammaden, Mahmoud H"},{"family":"Möhlenbruch","role":"aut","display":"Möhlenbruch, Markus Alfred","given":"Markus Alfred"},{"family":"Olive-Gadea","role":"aut","given":"Marta","display":"Olive-Gadea, Marta"},{"family":"Puri","role":"aut","given":"Ajit S","display":"Puri, Ajit S"},{"role":"aut","family":"Sakai","display":"Sakai, Nobuyuki","given":"Nobuyuki"},{"display":"Klein, Piers","given":"Piers","family":"Klein","role":"aut"},{"display":"Tomppo, Liisa","given":"Liisa","family":"Tomppo","role":"aut"},{"display":"Caparros, Francois","given":"Francois","role":"aut","family":"Caparros"},{"family":"Ramos","role":"aut","display":"Ramos, João Nuno","given":"João Nuno"},{"given":"Mouhammad","display":"Jumaa, Mouhammad","role":"aut","family":"Jumaa"},{"role":"aut","family":"Zaidi","display":"Zaidi, Syed","given":"Syed"},{"role":"aut","family":"Dobrocky","given":"Tomas","display":"Dobrocky, Tomas"},{"family":"Martinez-Majander","role":"aut","display":"Martinez-Majander, Nicolas","given":"Nicolas"},{"family":"Nannoni","role":"aut","given":"Stefania","display":"Nannoni, Stefania"},{"display":"Bellante, Flavio","given":"Flavio","family":"Bellante","role":"aut"},{"given":"Aaron","display":"Rodriguez-Calienes, Aaron","role":"aut","family":"Rodriguez-Calienes"},{"display":"Salazar-Marioni, Sergio","given":"Sergio","role":"aut","family":"Salazar-Marioni"},{"family":"Virtanen","role":"aut","display":"Virtanen, Pekka","given":"Pekka"},{"family":"Kaiser","role":"aut","display":"Kaiser, Daniel PO","given":"Daniel PO"},{"family":"Ventura","role":"aut","given":"Rita","display":"Ventura, Rita"},{"family":"Jesser","role":"aut","display":"Jesser, Jessica","given":"Jessica"},{"display":"Castonguay, Alicia C","given":"Alicia C","family":"Castonguay","role":"aut"},{"display":"Qureshi, Muhammad M","given":"Muhammad M","role":"aut","family":"Qureshi"},{"role":"aut","family":"Masoud","display":"Masoud, Hesham E","given":"Hesham E"},{"role":"aut","family":"Galecio-Castillo","display":"Galecio-Castillo, Milagros","given":"Milagros"},{"display":"Requena, Manuel","given":"Manuel","role":"aut","family":"Requena"},{"role":"aut","family":"Lauha","given":"Riikka","display":"Lauha, Riikka"},{"display":"Hu, Wei","given":"Wei","family":"Hu","role":"aut"},{"display":"Lin, Eugene","given":"Eugene","role":"aut","family":"Lin"},{"family":"Miao","role":"aut","display":"Miao, Zhongrong","given":"Zhongrong"},{"family":"Roy","role":"aut","given":"Daniel","display":"Roy, Daniel"},{"family":"Yamagami","role":"aut","given":"Hiroshi","display":"Yamagami, Hiroshi"},{"role":"aut","family":"Seiffge","display":"Seiffge, David J","given":"David J"},{"given":"Davide","display":"Strambo, Davide","role":"aut","family":"Strambo"},{"given":"Peter A","display":"Ringleb, Peter A","family":"Ringleb","role":"aut"},{"family":"Lemmens","role":"aut","given":"Robin","display":"Lemmens, Robin"},{"display":"Fischer, Urs","given":"Urs","family":"Fischer","role":"aut"},{"family":"Nguyen","role":"aut","given":"Thanh N","display":"Nguyen, Thanh N"},{"given":"Johannes","display":"Kaesmacher, Johannes","family":"Kaesmacher","role":"aut"}],"recId":"1910569836","note":["Gesehen am 02.12.2024"],"title":[{"title_sort":"Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke","title":"Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"11 S.","noteIll":"Illustrationen"}],"id":{"eki":["1910569836"],"doi":["10.1177/23969873241249406"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2396-9881"],"eki":["856122106"],"zdb":["2851287-X"]},"title":[{"subtitle":"ESJ","title":"European stroke journal","title_sort":"European stroke journal"}],"origin":[{"publisherPlace":"London","publisher":"Sage Publishing","dateIssuedDisp":"[2016]-"}],"name":{"displayForm":["European Stroke Organisation (ESO)"]},"recId":"856122106","disp":"Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic strokeEuropean stroke journal","type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"ESJ"}],"part":{"text":"9(2024), 4 vom: Mai, Seite 907-917","issue":"4","pages":"907-917","extent":"11","volume":"9","year":"2024"},"language":["eng"],"note":["Gesehen am 10.04.2024","Fortsetzung der Druck-Ausgabe"],"pubHistory":["Volume 1, issue 1 (March 2016)-"]}],"origin":[{"dateIssuedDisp":"May 17, 2024","dateIssuedKey":"2024"}]} | ||
| SRT | |a MUJANOVICASAFETYANDC1720 | ||