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Phasic and 24-h blood pressure control by endothelium-derived relaxing factor in conscious dogs

The effects of blocking endothelium-derived relaxing factor (EDRF) on 24-h blood pressure and heart rate (HR) were examined in six conscious freely moving foxhounds. The hypothesis tested was that shear stress-dependent EDRF release acts as a physiological blood pressure buffer. Telemetry recordings...

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Main Authors: Persson, Pontus B. (Author) , Baumann, J. Ê.. (Author) , Ehmke, Heimo (Author) , Nafz, Benno (Author) , Wittmann, Uwe (Author) , Kirchheim, Hartmut (Author)
Format: Article (Journal)
Language:English
Published: 1 May 1992
In: American journal of physiology. Heart and circulatory physiology
Year: 1992, Volume: 262, Issue: 5, Pages: H1395-H1400
ISSN:1522-1539
DOI:10.1152/ajpheart.1992.262.5.H1395
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpheart.1992.262.5.H1395
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/abs/10.1152/ajpheart.1992.262.5.H1395
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Author Notes:P.B. Persson, J.E. Baumann, H. Ehmke, B. Nafz, U. Wittmann, H.R. Kirchheim

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520 |a The effects of blocking endothelium-derived relaxing factor (EDRF) on 24-h blood pressure and heart rate (HR) were examined in six conscious freely moving foxhounds. The hypothesis tested was that shear stress-dependent EDRF release acts as a physiological blood pressure buffer. Telemetry recordings were obtained before and after the administration of the false substrate for EDRF synthesis NG-nitro-L-arginine (L-NNA, 16.5 +/- 2 mg/kg body wt iv). In response to L-NNA, mean arterial blood pressure (MAP) increased from 116 +/- 5 to 134 +/- 5 mmHg (P less than 0.01) and HR decreased from 97 +/- 6 to 68 +/- 3 beats/min over the entire 24-h period (P less than 0.01). The overall variability of MAP (as indicated by SD of frequency distribution) increased modestly from 9.5 +/- 0.4 to 11.7 +/- 1.1 mmHg (P less than 0.05). A sequential spectral analysis of blood pressure showed a 2.1-fold increase of power in the frequency range of 0.01-0.5 Hz (P less than 0.05) after L-NNA was given. In conclusion, blockade of EDRF led to a sustained hypertension throughout the whole 24-h recordings. Furthermore, EDRF acted as a physiological blood pressure buffer in the frequency range below 0.5 Hz. 
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