Cover Image

Blood pressure variability and urine flow in the conscious dog

Pressure-dependent urine production is considered to be a major factor in long-term blood pressure control. The phenomenon has been well characterized for fixed levels of renal perfusion pressure (RPP), but the influence of physiological fluctuations in RPP and spontaneous variations in renal blood...

Full description

Saved in:
Bibliographic Details
Main Authors: Nafz, Benno (Author) , Ehmke, Heimo (Author) , Wagner, Claus D. (Author) , Kirchheim, Hartmut (Author) , Persson, Pontus B. (Author)
Format: Article (Journal)
Language:English
Published: April 1, 1998
In: American journal of physiology. Renal physiology
Year: 1998, Volume: 274, Issue: 4, Pages: F680-F686
ISSN:1522-1466
DOI:10.1152/ajprenal.1998.274.4.F680
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajprenal.1998.274.4.F680
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajprenal.1998.274.4.F680
Get full text
Author Notes:Benno Nafz, Heimo Ehmke, Claus D. Wagner, Hartmut R. Kirchheim, Pontus B. Persson

MARC

LEADER 00000caa a2200000 c 4500
001 1910589586
003 DE-627
005 20250716213604.0
007 cr uuu---uuuuu
008 241202s1998 xx |||||o 00| ||eng c
024 7 |a 10.1152/ajprenal.1998.274.4.F680  |2 doi 
035 |a (DE-627)1910589586 
035 |a (DE-599)KXP1910589586 
035 |a (OCoLC)1528014331 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Nafz, Benno  |d 1966-  |e VerfasserIn  |0 (DE-588)129456179  |0 (DE-627)397663471  |0 (DE-576)297668781  |4 aut 
245 1 0 |a Blood pressure variability and urine flow in the conscious dog  |c Benno Nafz, Heimo Ehmke, Claus D. Wagner, Hartmut R. Kirchheim, Pontus B. Persson 
264 1 |c April 1, 1998 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 02.12.2024 
520 |a Pressure-dependent urine production is considered to be a major factor in long-term blood pressure control. The phenomenon has been well characterized for fixed levels of renal perfusion pressure (RPP), but the influence of physiological fluctuations in RPP and spontaneous variations in renal blood flow (RBF) on short-term urine flow (UV) remain unclear. To clarify this issue, we studied the interdependence of RPP, RBF, and UV in 13 conscious foxhounds during a single-step pressure reduction, under normal conditions, and with induced pressure changes. Reducing RPP in a single step to ∼80 mmHg revealed short response times of RBF (0.4 ± 0.1 s, n = 7) as well as of UV (8.1 ± 0.8 s, n = 7). Under control conditions, UV was coupled with spontaneous variations of RBF (r = 0.94,P < 0.001), in contrast to RPP, which showed no significant correlation with UV (r = 0.09,P = NS). To discern the pressure and blood flow dependency of UV at a reduced RPP, we induced 0.9-mHz blood pressure oscillations (80 ± 10 mmHg), which phase shifted RPP and RBF. Conversely, under these conditions, UV was dependent on RPP (r = 0.95,P < 0.001). These results suggest that spontaneous fluctuations in RBF around a normal baseline level lead to concomitant changes in urine production, in contrast to physiological short-term oscillations in RPP, which are not correlated to changes in UV. However, during induced oscillations of perfusion pressure, the blood flow dependence was no longer observed and UV was entirely pressure dependent. 
650 4 |a blood pressure oscillations 
650 4 |a pressure diuresis 
650 4 |a renal blood flow 
650 4 |a renal hemodynamics 
650 4 |a resting conscious dog 
700 1 |a Ehmke, Heimo  |e VerfasserIn  |0 (DE-588)1027511597  |0 (DE-627)729273695  |0 (DE-576)373290314  |4 aut 
700 1 |a Wagner, Claus D.  |e VerfasserIn  |4 aut 
700 1 |a Kirchheim, Hartmut  |d 1934-  |e VerfasserIn  |0 (DE-588)1018414541  |0 (DE-627)690601158  |0 (DE-576)355743469  |4 aut 
700 1 |a Persson, Pontus B.  |e VerfasserIn  |0 (DE-588)1112496696  |0 (DE-627)866476806  |0 (DE-576)164907696  |4 aut 
773 0 8 |i Enthalten in  |t American journal of physiology. Renal physiology  |d Bethesda, Md. : Soc., 1977  |g 274(1998), 4, Seite F680-F686  |h Online-Ressource  |w (DE-627)270426051  |w (DE-600)1477287-5  |w (DE-576)079718787  |x 1522-1466  |7 nnas  |a Blood pressure variability and urine flow in the conscious dog 
773 1 8 |g volume:274  |g year:1998  |g number:4  |g pages:F680-F686  |g extent:7  |a Blood pressure variability and urine flow in the conscious dog 
856 4 0 |u https://doi.org/10.1152/ajprenal.1998.274.4.F680  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://journals.physiology.org/doi/full/10.1152/ajprenal.1998.274.4.F680  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20241202 
993 |a Article 
994 |a 1998 
998 |g 1018414541  |a Kirchheim, Hartmut  |m 1018414541:Kirchheim, Hartmut  |d 50000  |d 53200  |e 50000PK1018414541  |e 53200PK1018414541  |k 0/50000/  |k 1/50000/53200/  |p 4 
998 |g 1027511597  |a Ehmke, Heimo  |m 1027511597:Ehmke, Heimo  |d 50000  |d 53200  |e 50000PE1027511597  |e 53200PE1027511597  |k 0/50000/  |k 1/50000/53200/  |p 2 
999 |a KXP-PPN1910589586  |e 462979980X 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 02.12.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1910589586","language":["eng"],"title":[{"title":"Blood pressure variability and urine flow in the conscious dog","title_sort":"Blood pressure variability and urine flow in the conscious dog"}],"person":[{"family":"Nafz","given":"Benno","display":"Nafz, Benno","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ehmke, Heimo","given":"Heimo","family":"Ehmke"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wagner, Claus D.","given":"Claus D.","family":"Wagner"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kirchheim, Hartmut","given":"Hartmut","family":"Kirchheim"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Persson, Pontus B.","given":"Pontus B.","family":"Persson"}],"physDesc":[{"extent":"7 S."}],"relHost":[{"name":{"displayForm":["publ. by the American Physiological Society"]},"origin":[{"publisherPlace":"Bethesda, Md.","dateIssuedDisp":"1977-","publisher":"Soc.","dateIssuedKey":"1977"}],"id":{"zdb":["1477287-5"],"eki":["270426051"],"issn":["1522-1466"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"partname":"Renal physiology","title_sort":"American journal of physiology","title":"American journal of physiology"}],"disp":"Blood pressure variability and urine flow in the conscious dogAmerican journal of physiology. Renal physiology","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 05.02.20"],"language":["eng"],"corporate":[{"display":"American Physiological Society","roleDisplay":"Herausgebendes Organ","role":"isb"}],"recId":"270426051","pubHistory":["232.1977 -"],"titleAlt":[{"title":"American journal of physiology / Renal physiology"},{"title":"Renal, fluid and electrolyte physiology"}],"part":{"extent":"7","text":"274(1998), 4, Seite F680-F686","volume":"274","pages":"F680-F686","issue":"4","year":"1998"}}],"origin":[{"dateIssuedKey":"1998","dateIssuedDisp":"April 1, 1998"}],"id":{"eki":["1910589586"],"doi":["10.1152/ajprenal.1998.274.4.F680"]},"name":{"displayForm":["Benno Nafz, Heimo Ehmke, Claus D. Wagner, Hartmut R. Kirchheim, Pontus B. Persson"]}} 
SRT |a NAFZBENNOEBLOODPRESS1199 

Similar Items