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Evaluation of carbon-11-labelled phenoxy bridged fatty acids for studying myocardial fatty acid metabolism with PET

A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesised and evaluated in mice in an in vivo tissue distribution study. Of these three, 1-[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3...

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Bibliographic Details
Main Authors: Groot, Tjibbe de (Author) , Maris, Bart (Author) , Boonen, Carine (Author) , Bormans, Guy (Author) , Mortelmans, Luc (Author) , Eisenhut, Michael (Author) , Verbruggen, Alfons (Author)
Format: Article (Journal)
Language:English
Published: July 1997
In: Nuclear medicine and biology
Year: 1997, Volume: 24, Issue: 5, Pages: 461-464
ISSN:1872-9614
DOI:10.1016/S0969-8051(97)80015-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0969-8051(97)80015-7
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0969805197800157
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Author Notes:Tjibbe de Groot, Bart Maris, Carine Boonen, Guy Bormans, Luc Mortelmans, Michael Eisenhut, Alfons Verbruggen
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Summary:A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesised and evaluated in mice in an in vivo tissue distribution study. Of these three, 1-[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3) showed the most favourable uptake in the myocardium: 1.2% of the injected dose at 30 min p.i., vs. 0.6% for [11C]palmitate. The metabolic stability of C12C3 and [11C]palmitate was assessed by determining the amount of exhaled [11C]CO2 during a 30-min interval after injection. It was found that the phenoxy moiety in the γ-position did not prevent the metabolic degradation of C12C3: After 30 min 20.7% of the injected dose was exhaled as [11C]CO2 vs. 12.7% for [11C]palmitate.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 24. Dezember 2002
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Physical Description:Online Resource
ISSN:1872-9614
DOI:10.1016/S0969-8051(97)80015-7

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