Evaluation of carbon-11-labelled phenoxy bridged fatty acids for studying myocardial fatty acid metabolism with PET
A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesised and evaluated in mice in an in vivo tissue distribution study. Of these three, 1-[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 1997
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| In: |
Nuclear medicine and biology
Year: 1997, Jahrgang: 24, Heft: 5, Pages: 461-464 |
| ISSN: | 1872-9614 |
| DOI: | 10.1016/S0969-8051(97)80015-7 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0969-8051(97)80015-7 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0969805197800157 
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| Verfasserangaben: | Tjibbe de Groot, Bart Maris, Carine Boonen, Guy Bormans, Luc Mortelmans, Michael Eisenhut, Alfons Verbruggen |
MARC
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| 245 | 1 | 0 | |a Evaluation of carbon-11-labelled phenoxy bridged fatty acids for studying myocardial fatty acid metabolism with PET |c Tjibbe de Groot, Bart Maris, Carine Boonen, Guy Bormans, Luc Mortelmans, Michael Eisenhut, Alfons Verbruggen |
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| 520 | |a A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesised and evaluated in mice in an in vivo tissue distribution study. Of these three, 1-[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3) showed the most favourable uptake in the myocardium: 1.2% of the injected dose at 30 min p.i., vs. 0.6% for [11C]palmitate. The metabolic stability of C12C3 and [11C]palmitate was assessed by determining the amount of exhaled [11C]CO2 during a 30-min interval after injection. It was found that the phenoxy moiety in the γ-position did not prevent the metabolic degradation of C12C3: After 30 min 20.7% of the injected dose was exhaled as [11C]CO2 vs. 12.7% for [11C]palmitate. | ||
| 650 | 4 | |a Carbon-11 | |
| 650 | 4 | |a Fatty acids | |
| 650 | 4 | |a Metabolic trapping | |
| 650 | 4 | |a PET | |
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| 700 | 1 | |a Boonen, Carine |e VerfasserIn |4 aut | |
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