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Evaluation of carbon-11-labelled phenoxy bridged fatty acids for studying myocardial fatty acid metabolism with PET

A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesised and evaluated in mice in an in vivo tissue distribution study. Of these three, 1-[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3...

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Hauptverfasser: Groot, Tjibbe de (VerfasserIn) , Maris, Bart (VerfasserIn) , Boonen, Carine (VerfasserIn) , Bormans, Guy (VerfasserIn) , Mortelmans, Luc (VerfasserIn) , Eisenhut, Michael (VerfasserIn) , Verbruggen, Alfons (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: July 1997
In: Nuclear medicine and biology
Year: 1997, Jahrgang: 24, Heft: 5, Pages: 461-464
ISSN:1872-9614
DOI:10.1016/S0969-8051(97)80015-7
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0969-8051(97)80015-7
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0969805197800157
Volltext
Verfasserangaben:Tjibbe de Groot, Bart Maris, Carine Boonen, Guy Bormans, Luc Mortelmans, Michael Eisenhut, Alfons Verbruggen
Beschreibung
Zusammenfassung:A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesised and evaluated in mice in an in vivo tissue distribution study. Of these three, 1-[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3) showed the most favourable uptake in the myocardium: 1.2% of the injected dose at 30 min p.i., vs. 0.6% for [11C]palmitate. The metabolic stability of C12C3 and [11C]palmitate was assessed by determining the amount of exhaled [11C]CO2 during a 30-min interval after injection. It was found that the phenoxy moiety in the γ-position did not prevent the metabolic degradation of C12C3: After 30 min 20.7% of the injected dose was exhaled as [11C]CO2 vs. 12.7% for [11C]palmitate.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe 24. Dezember 2002
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Beschreibung:Online Resource
ISSN:1872-9614
DOI:10.1016/S0969-8051(97)80015-7

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