Microglia: a promising therapeutic target in spinal cord injury
Microglia are present throughout the central nervous system and are vital in neural repair, nutrition, phagocytosis, immunological regulation, and maintaining neuronal function. In a healthy spinal cord, microglia are accountable for immune surveillance, however, when a spinal cord injury occurs, th...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2025
|
| In: |
Neural regeneration research
Year: 2025, Jahrgang: 20, Heft: 2, Pages: 1-10 |
| ISSN: | 1876-7958 |
| DOI: | 10.4103/NRR.NRR-D-23-02044 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.4103/NRR.NRR-D-23-02044 Verlag, kostenfrei, Volltext: https://journals.lww.com/nrronline/fulltext/2025/02000/microglia__a_promising_therapeutic_target_in.13.aspx 
|
| Verfasserangaben: | Xiaowei Zha, Guoli Zheng, Thomas Skutella, Karl Kiening, Andreas Unterberg, Alexander Younsi |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1911197312 | ||
| 003 | DE-627 | ||
| 005 | 20250716214620.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241209s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4103/NRR.NRR-D-23-02044 |2 doi | |
| 035 | |a (DE-627)1911197312 | ||
| 035 | |a (DE-599)KXP1911197312 | ||
| 035 | |a (OCoLC)1528014761 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zha, Xiaowei |e VerfasserIn |0 (DE-588)135049870X |0 (DE-627)1911197886 |4 aut | |
| 245 | 1 | 0 | |a Microglia |b a promising therapeutic target in spinal cord injury |c Xiaowei Zha, Guoli Zheng, Thomas Skutella, Karl Kiening, Andreas Unterberg, Alexander Younsi |
| 264 | 1 | |c February 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 16. April 2024 | ||
| 500 | |a Gesehen am 09.12.2024 | ||
| 520 | |a Microglia are present throughout the central nervous system and are vital in neural repair, nutrition, phagocytosis, immunological regulation, and maintaining neuronal function. In a healthy spinal cord, microglia are accountable for immune surveillance, however, when a spinal cord injury occurs, the microenvironment drastically changes, leading to glial scars and failed axonal regeneration. In this context, microglia vary their gene and protein expression during activation, and proliferation in reaction to the injury, influencing injury responses both favorably and unfavorably. A dynamic and multifaceted injury response is mediated by microglia, which interact directly with neurons, astrocytes, oligodendrocytes, and neural stem/progenitor cells. Despite a clear understanding of their essential nature and origin, the mechanisms of action and new functions of microglia in spinal cord injury require extensive research. This review summarizes current studies on microglial genesis, physiological function, and pathological state, highlights their crucial roles in spinal cord injury, and proposes microglia as a therapeutic target. | ||
| 700 | 1 | |a Zheng, Guoli |d 1989- |e VerfasserIn |0 (DE-588)1199567183 |0 (DE-627)1681875667 |4 aut | |
| 700 | 1 | |a Skutella, Thomas |d 1963- |e VerfasserIn |0 (DE-588)120568225 |0 (DE-627)080752047 |0 (DE-576)180448390 |4 aut | |
| 700 | 1 | |a Kiening, Karl |d 1959- |e VerfasserIn |0 (DE-588)128746262 |0 (DE-627)379124599 |0 (DE-576)297310917 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 700 | 1 | |a Younsi, Alexander |d 1985- |e VerfasserIn |0 (DE-588)104607508X |0 (DE-627)775681547 |0 (DE-576)39935882X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neural regeneration research |d Mumbai : Wolters Kluwer Health Medknow, 2006 |g 20(2025), 2 vom: Feb., Artikel-ID 454, Seite 1-10 |h Online-Ressource |w (DE-627)545785499 |w (DE-600)2388460-5 |w (DE-576)272715379 |x 1876-7958 |7 nnas |a Microglia a promising therapeutic target in spinal cord injury |
| 773 | 1 | 8 | |g volume:20 |g year:2025 |g number:2 |g month:02 |g elocationid:454 |g pages:1-10 |g extent:10 |a Microglia a promising therapeutic target in spinal cord injury |
| 856 | 4 | 0 | |u https://doi.org/10.4103/NRR.NRR-D-23-02044 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/nrronline/fulltext/2025/02000/microglia__a_promising_therapeutic_target_in.13.aspx |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241209 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 104607508X |a Younsi, Alexander |m 104607508X:Younsi, Alexander |d 910000 |d 911200 |d 50000 |e 910000PY104607508X |e 911200PY104607508X |e 50000PY104607508X |k 0/910000/ |k 1/910000/911200/ |k 0/50000/ |p 6 |y j | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ |p 5 | ||
| 998 | |g 128746262 |a Kiening, Karl |m 128746262:Kiening, Karl |d 910000 |d 911200 |d 50000 |e 910000PK128746262 |e 911200PK128746262 |e 50000PK128746262 |k 0/910000/ |k 1/910000/911200/ |k 0/50000/ |p 4 | ||
| 998 | |g 120568225 |a Skutella, Thomas |m 120568225:Skutella, Thomas |d 50000 |d 53100 |e 50000PS120568225 |e 53100PS120568225 |k 0/50000/ |k 1/50000/53100/ |p 3 | ||
| 998 | |g 1199567183 |a Zheng, Guoli |m 1199567183:Zheng, Guoli |p 2 | ||
| 999 | |a KXP-PPN1911197312 |e 4633329618 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Microglia","subtitle":"a promising therapeutic target in spinal cord injury","title_sort":"Microglia"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"February 2025","dateIssuedKey":"2025"}],"recId":"1911197312","physDesc":[{"noteIll":"Illustrationen","extent":"10 S."}],"id":{"eki":["1911197312"],"doi":["10.4103/NRR.NRR-D-23-02044"]},"note":["Online veröffentlicht: 16. April 2024","Gesehen am 09.12.2024"],"relHost":[{"recId":"545785499","origin":[{"publisherPlace":"Mumbai ; Singapore [u.a.] ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"2006","publisher":"Wolters Kluwer Health Medknow ; Elsevier ; Ovid","dateIssuedDisp":"2006-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"NRR"}],"id":{"issn":["1876-7958"],"zdb":["2388460-5"],"eki":["545785499"]},"disp":"Microglia a promising therapeutic target in spinal cord injuryNeural regeneration research","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 08.07.20"],"title":[{"title":"Neural regeneration research","subtitle":"NRR","title_sort":"Neural regeneration research"}],"part":{"pages":"1-10","extent":"10","issue":"2","text":"20(2025), 2 vom: Feb., Artikel-ID 454, Seite 1-10","year":"2025","volume":"20"},"language":["eng"],"pubHistory":["1.2006 -"]}],"name":{"displayForm":["Xiaowei Zha, Guoli Zheng, Thomas Skutella, Karl Kiening, Andreas Unterberg, Alexander Younsi"]},"person":[{"family":"Zha","role":"aut","given":"Xiaowei","display":"Zha, Xiaowei"},{"family":"Zheng","display":"Zheng, Guoli","given":"Guoli","role":"aut"},{"role":"aut","given":"Thomas","display":"Skutella, Thomas","family":"Skutella"},{"given":"Karl","role":"aut","display":"Kiening, Karl","family":"Kiening"},{"given":"Andreas","role":"aut","display":"Unterberg, Andreas","family":"Unterberg"},{"family":"Younsi","given":"Alexander","role":"aut","display":"Younsi, Alexander"}]} | ||
| SRT | |a ZHAXIAOWEIMICROGLIA2025 | ||