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The influence of alkylating agents on sulfur-sulfur bonds in per- and polysulfides

Per- and polysulfides are sulfane sulfur species produced inside living cells, in organisms as diverse as bacteria, plants and humans, but their biological roles remain to be fully understood. Unfortunately, due to their reactivity, per- and polysulfides are easily altered, interconverted or lost du...

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Main Authors: Schilling, Danny (Author) , Ditrói, Tamás (Author) , Barayeu, Uladzimir (Author) , Jurányi, Eszter Petra (Author) , Nagy, Peter (Author) , Dick, Tobias P. (Author)
Format: Article (Journal)
Language:English
Published: October 2023
In: Current opinion in chemical biology
Year: 2023, Volume: 76, Pages: 1-8
ISSN:1879-0402
DOI:10.1016/j.cbpa.2023.102368
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.cbpa.2023.102368
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1367593123001060
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Author Notes:Danny Schilling, Tamás Ditrói, Uladzimir Barayeu, Eszter Petra Jurányi, Peter Nagy and Tobias P. Dick

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520 |a Per- and polysulfides are sulfane sulfur species produced inside living cells, in organisms as diverse as bacteria, plants and humans, but their biological roles remain to be fully understood. Unfortunately, due to their reactivity, per- and polysulfides are easily altered, interconverted or lost during the processing and analysis of biological material. Thus, all current analytical methods make use of alkylating agents, to quench reactivity of hydropersulfides and hydropolysulfides and also to prevent free thiols from attacking sulfur chains in hydropolysulfides and dialkyl polysulfides. However, recent findings reveal that alkylating agents can also destroy per- and polysulfides, to varying degrees, depending on the choice of alkylating agent. Here, we discuss the challenges associated with the alkylation of per- and polysulfides, the single most important step for their preservation and detection in biological samples. 
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