Buchumschlag

Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast

The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy pl...

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Hauptverfasser: Hawighorst, Hans (VerfasserIn) , Schreiber, Wolfgang (VerfasserIn) , Knopp, Michael V. (VerfasserIn) , Essig, Marco (VerfasserIn) , Engenhart, Rita (VerfasserIn) , Brix, Gunnar (VerfasserIn) , Kaick, Gerhard van (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1996
In: Magnetic resonance imaging
Year: 1996, Jahrgang: 14, Heft: 10, Pages: 1119-1126
ISSN:1873-5894
DOI:10.1016/S0730-725X(96)00241-X
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0730-725X(96)00241-X
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X9600241X
Volltext
Verfasserangaben:Hans Hawighorst, Wolfgang Schreiber, Michael V. Knopp, Marco Essig, Rita Engenhart-Cabilic, Gunnar Brix, Gerhard van Kaick
Beschreibung
Zusammenfassung:The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy planning. Nineteen patients (age 24-60 years) with histologically proven malignant glioma were prospectively examined by MR imaging. After the administration of gadolinium dimeglumine (0.1 mmol/kg body weight), the lesions were imaged with an MT-weighted FLASH (fast, low-angle shot) pulse sequence and with a conventional T1-weighted spin-echo (SE) sequence without MT saturation. The mean tumor volumes of gliomas measured on MT-weighted FLASH images were significantly (p < .01) larger than those obtained from T1-weighted SE images (45 ± 15 cm3 vs. 33 ± 10 cm3). The mean contrast-to-noise ratio of enhancing lesions on MT-weighted FLASH was 48 ± 14 compared with 30 ± 14 on SE images, representing a significant (p < .01) improvement. We conclude that the volume of contrast enhancement of malignant glioma identified on MT-weighted FLASH images represents the area of disrupted blood-brain barrier. If this volume of subtle contrast enhancement is caused by tumor infiltration and represents the boost target volume for stereotactic radiosurgery or brachytherapy, MT-weighted FLASH images would be better than T1-weighted SE images to define these volumes. These improved delineation of areas at highest risk for recurrence following radiation therapy should enhance the efficacy of treatment planning for high-boost therapy.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe 25. März 1999
Gesehen am 12.12.2024
Beschreibung:Online Resource
ISSN:1873-5894
DOI:10.1016/S0730-725X(96)00241-X

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