Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast
The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy pl...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1996
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| In: |
Magnetic resonance imaging
Year: 1996, Jahrgang: 14, Heft: 10, Pages: 1119-1126 |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/S0730-725X(96)00241-X |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0730-725X(96)00241-X Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X9600241X 
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| Verfasserangaben: | Hans Hawighorst, Wolfgang Schreiber, Michael V. Knopp, Marco Essig, Rita Engenhart-Cabilic, Gunnar Brix, Gerhard van Kaick |
MARC
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| 245 | 1 | 0 | |a Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast |c Hans Hawighorst, Wolfgang Schreiber, Michael V. Knopp, Marco Essig, Rita Engenhart-Cabilic, Gunnar Brix, Gerhard van Kaick |
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| 520 | |a The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy planning. Nineteen patients (age 24-60 years) with histologically proven malignant glioma were prospectively examined by MR imaging. After the administration of gadolinium dimeglumine (0.1 mmol/kg body weight), the lesions were imaged with an MT-weighted FLASH (fast, low-angle shot) pulse sequence and with a conventional T1-weighted spin-echo (SE) sequence without MT saturation. The mean tumor volumes of gliomas measured on MT-weighted FLASH images were significantly (p < .01) larger than those obtained from T1-weighted SE images (45 ± 15 cm3 vs. 33 ± 10 cm3). The mean contrast-to-noise ratio of enhancing lesions on MT-weighted FLASH was 48 ± 14 compared with 30 ± 14 on SE images, representing a significant (p < .01) improvement. We conclude that the volume of contrast enhancement of malignant glioma identified on MT-weighted FLASH images represents the area of disrupted blood-brain barrier. If this volume of subtle contrast enhancement is caused by tumor infiltration and represents the boost target volume for stereotactic radiosurgery or brachytherapy, MT-weighted FLASH images would be better than T1-weighted SE images to define these volumes. These improved delineation of areas at highest risk for recurrence following radiation therapy should enhance the efficacy of treatment planning for high-boost therapy. | ||
| 650 | 4 | |a Irradiation | |
| 650 | 4 | |a Magnetic resonance (MR) | |
| 650 | 4 | |a Magnetization transfer (MT) technique | |
| 650 | 4 | |a Malignant glioma | |
| 650 | 4 | |a Radiation therapy | |
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| 700 | 1 | |a Knopp, Michael V. |e VerfasserIn |0 (DE-588)1076637442 |0 (DE-627)835139344 |0 (DE-576)167521527 |4 aut | |
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