Long-term outcome after helical tomotherapy following breast conserving surgery for ductal carcinoma in situ
Background: This retrospective study aimed to investigate the outcomes and adverse events (AEs) associated with adjuvant radiotherapy with helical tomotherapy (hT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). Methods: Twenty-eight patients with DCIS underwent postoperat...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 23, 2024
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| In: |
Technology in cancer research & treatment
Year: 2024, Jahrgang: 23, Pages: 1-13 |
| ISSN: | 1533-0338 |
| DOI: | 10.1177/15330338241264847 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/15330338241264847
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| Verfasserangaben: | Henrik Hauswald, Michael Schempp, Pauline Liebig, Sebastian Hoefel, Jürgen Debus, Peter E. Huber, and Felix Zwicker |
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| 245 | 1 | 0 | |a Long-term outcome after helical tomotherapy following breast conserving surgery for ductal carcinoma in situ |c Henrik Hauswald, Michael Schempp, Pauline Liebig, Sebastian Hoefel, Jürgen Debus, Peter E. Huber, and Felix Zwicker |
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| 520 | |a Background: This retrospective study aimed to investigate the outcomes and adverse events (AEs) associated with adjuvant radiotherapy with helical tomotherapy (hT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). Methods: Twenty-eight patients with DCIS underwent postoperative hT between 2011 and 2020. hT was chosen since it provided optimal target coverage and tolerable organ-at-risk doses to the lungs and heart when tangential 3-dimensional conformal radiotherapy (3D-CRT) was presumed to provide unfavorable dosimetry. The median total (single) dose was 50.4 Gy (1.8 Gy). The median time between BCS and the start of hT was 5 weeks (range, 4-38 weeks). Statistical analysis included local recurrence-free survival, overall survival (OS), and secondary cancer-free survival. AEs were classified according to the Common Toxicity Criteria for Adverse Events, version 5. Results: The patients’ median age was 58 years. The median follow-up period was 61 months (range, 3-123 months). The 1-, 3-, and 5-year OS rates were 100% each. None of the patients developed secondary cancer, local recurrence, or invasive breast cancer during follow-up. The most common acute AEs were dermatitis (n = 27), fatigue (n = 4), hyperpigmentation (n = 3), and thrombocytopenia (n = 4). The late AE primarily included surgical scars (n = 7) and hyperpigmentation (n = 5). None of the patients experienced acute or late AEs > grade 3. The mean conformity and homogeneity indices were 0.9 (range, 0.86-0.96) and 0.056 (range, 0.05-0.06), respectively. Conclusion: hT after BCS for DCIS is a feasible and safe form of adjuvant radiotherapy for patients in whom 3D-CRT is contraindicated due to unfavorable dosimetry. During follow-up, there were no recurrences, invasive breast cancer diagnoses, or secondary cancers, while the adverse effects were mild. | ||
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| 700 | 1 | |a Liebig, Pauline |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoefel, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
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| 700 | 1 | |a Zwicker, Felix |d 1978- |e VerfasserIn |0 (DE-588)129202223 |0 (DE-627)390706892 |0 (DE-576)29753730X |4 aut | |
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