When size matters: a novel compact Cas12a variant for in vivo genome editing

A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors.

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Bubeck, Felix (VerfasserIn) , Grimm, Dirk (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: July 17, 2024
In: PLoS biology
Year: 2024, Jahrgang: 22, Heft: 7, Pages: 1-4
ISSN:1545-7885
DOI:10.1371/journal.pbio.3002637
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pbio.3002637
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002637
Volltext
Verfasserangaben:Felix Bubeck, Dirk Grimm

MARC

LEADER 00000caa a2200000 c 4500
001 1912193833
003 DE-627
005 20250716215641.0
007 cr uuu---uuuuu
008 241212s2024 xx |||||o 00| ||eng c
024 7 |a 10.1371/journal.pbio.3002637  |2 doi 
035 |a (DE-627)1912193833 
035 |a (DE-599)KXP1912193833 
035 |a (OCoLC)1528015323 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Bubeck, Felix  |d 1992-  |e VerfasserIn  |0 (DE-588)1172685525  |0 (DE-627)104131955X  |0 (DE-576)514732695  |4 aut 
245 1 0 |a When size matters  |b a novel compact Cas12a variant for in vivo genome editing  |c Felix Bubeck, Dirk Grimm 
264 1 |c July 17, 2024 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 12.12.2024 
520 |a A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors. 
650 4 |a CRISPR 
650 4 |a Genetic loci 
650 4 |a Genomics 
650 4 |a Hepatocytes 
650 4 |a Mammalian genomics 
650 4 |a Viral genomics 
650 4 |a Viral packaging 
650 4 |a Viral vectors 
700 1 |a Grimm, Dirk  |e VerfasserIn  |0 (DE-588)1016476671  |0 (DE-627)70553376X  |0 (DE-576)352260645  |4 aut 
773 0 8 |i Enthalten in  |a Public Library of Science  |t PLoS biology  |d Lawrence, KS : PLoS, 2003  |g 22(2024), 7, Artikel-ID e3002637, Seite 1-4  |h Online-Ressource  |w (DE-627)373755597  |w (DE-600)2126773-X  |w (DE-576)109104846  |x 1545-7885  |7 nnas 
773 1 8 |g volume:22  |g year:2024  |g number:7  |g elocationid:e3002637  |g pages:1-4  |g extent:4  |a When size matters a novel compact Cas12a variant for in vivo genome editing 
856 4 0 |u https://doi.org/10.1371/journal.pbio.3002637  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002637  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20241212 
993 |a Article 
994 |a 2024 
998 |g 1016476671  |a Grimm, Dirk  |m 1016476671:Grimm, Dirk  |d 910000  |d 911700  |e 910000PG1016476671  |e 911700PG1016476671  |k 0/910000/  |k 1/910000/911700/  |p 2  |y j 
998 |g 1172685525  |a Bubeck, Felix  |m 1172685525:Bubeck, Felix  |d 910000  |d 911700  |e 910000PB1172685525  |e 911700PB1172685525  |k 0/910000/  |k 1/910000/911700/  |p 1  |x j 
999 |a KXP-PPN1912193833  |e 4635142892 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Felix Bubeck, Dirk Grimm"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1912193833","title":[{"title":"When size matters","subtitle":"a novel compact Cas12a variant for in vivo genome editing","title_sort":"When size matters"}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"July 17, 2024"}],"relHost":[{"part":{"pages":"1-4","text":"22(2024), 7, Artikel-ID e3002637, Seite 1-4","year":"2024","issue":"7","volume":"22","extent":"4"},"name":{"displayForm":["Public Library of Science"]},"pubHistory":["1.2003 -"],"language":["eng"],"corporate":[{"roleDisplay":"VerfasserIn","display":"Public Library of Science","role":"aut"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"373755597","title":[{"title":"PLoS biology","title_sort":"PLoS biology"}],"disp":"Public Library of SciencePLoS biology","origin":[{"dateIssuedDisp":"2003-","publisher":"PLoS","dateIssuedKey":"2003","publisherPlace":"Lawrence, KS"}],"titleAlt":[{"title":"Biology"}],"id":{"issn":["1545-7885"],"eki":["373755597"],"zdb":["2126773-X"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 25.08.20"]}],"id":{"eki":["1912193833"],"doi":["10.1371/journal.pbio.3002637"]},"physDesc":[{"extent":"4 S."}],"note":["Gesehen am 12.12.2024"],"person":[{"given":"Felix","display":"Bubeck, Felix","role":"aut","roleDisplay":"VerfasserIn","family":"Bubeck"},{"roleDisplay":"VerfasserIn","family":"Grimm","given":"Dirk","role":"aut","display":"Grimm, Dirk"}]} 
SRT |a BUBECKFELIWHENSIZEMA1720