GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
Leukemia stem cells (LSCs) share numerous features with healthy hematopoietic stem cells (HSCs). G-protein coupled receptor family C group 5 member C (GPRC5C) is a regulator of HSC dormancy. However, GPRC5C functionality in acute myeloid leukemia (AML) is yet to be determined. Within patient AML coh...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 26 2023
|
| In: |
Blood advances
Year: 2023, Jahrgang: 7, Heft: 24, Pages: 7525-7538 |
| ISSN: | 2473-9537 |
| DOI: | 10.1182/bloodadvances.2023010460 |
| Schlagworte: | |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/bloodadvances.2023010460
|
| Verfasserangaben: | Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau, Josée Hébert, Bernhard Lehnertz, Guy Sauvageau, Pablo Menendez, and Nina Cabezas-Wallscheid |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1912202077 | ||
| 003 | DE-627 | ||
| 005 | 20250716215709.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241212s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/bloodadvances.2023010460 |2 doi | |
| 035 | |a (DE-627)1912202077 | ||
| 035 | |a (DE-599)KXP1912202077 | ||
| 035 | |a (OCoLC)1528015164 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Zhang, Yu Wei |e VerfasserIn |0 (DE-588)1269637002 |0 (DE-627)1818150476 |4 aut | |
| 245 | 1 | 0 | |a GPRC5C drives branched-chain amino acid metabolism in leukemogenesis |c Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau, Josée Hébert, Bernhard Lehnertz, Guy Sauvageau, Pablo Menendez, and Nina Cabezas-Wallscheid |
| 264 | 1 | |c December 26 2023 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.12.2024 | ||
| 520 | |a Leukemia stem cells (LSCs) share numerous features with healthy hematopoietic stem cells (HSCs). G-protein coupled receptor family C group 5 member C (GPRC5C) is a regulator of HSC dormancy. However, GPRC5C functionality in acute myeloid leukemia (AML) is yet to be determined. Within patient AML cohorts, high GPRC5C levels correlated with poorer survival. Ectopic Gprc5c expression increased AML aggression through the activation of NF-κB, which resulted in an altered metabolic state with increased levels of intracellular branched-chain amino acids (BCAAs). This onco-metabolic profile was reversed upon loss of Gprc5c, which also abrogated the leukemia-initiating potential. Targeting the BCAA transporter SLC7A5 with JPH203 inhibited oxidative phosphorylation and elicited strong antileukemia effects, specifically in mouse and patient AML samples while sparing healthy bone marrow cells. This antileukemia effect was strengthened in the presence of venetoclax and azacitidine. Our results indicate that the GPRC5C-NF-κB-SLC7A5-BCAAs axis is a therapeutic target that can compromise leukemia stem cell function in AML. | ||
| 689 | 0 | 0 | |d s |0 (DE-588)7723480-7 |0 (DE-627)638936861 |0 (DE-576)333144198 |a G-Protein gekoppelter Rezeptor |2 gnd |
| 689 | 0 | |5 (DE-627) | |
| 700 | 1 | |a Velasco-Hernandez, Talia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mess, Julian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lalioti, Maria-Eleni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Romero-Mulero, Mari Carmen |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Obier, Nadine |d 1982- |e VerfasserIn |0 (DE-588)14320274X |0 (DE-627)64512088X |0 (DE-576)336609760 |4 aut | |
| 700 | 1 | |a Karantzelis, Nikolaos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rettkowski, Jasmin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schönberger, Katharina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karabacz, Noémie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jäcklein, Karin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morishima, Tatsuya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trincado, Juan Luis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Romecin, Paola |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinez, Alba |e VerfasserIn |4 aut | |
| 700 | 1 | |a Takizawa, Hitoshi |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Shoumariyeh, Khalid |e VerfasserIn |0 (DE-588)1176439138 |0 (DE-627)104743444X |0 (DE-576)516628089 |4 aut | |
| 700 | 1 | |a Renders, Simon |e VerfasserIn |0 (DE-588)1207477311 |0 (DE-627)1693807467 |4 aut | |
| 700 | 1 | |8 3\p |a Zeiser, Robert |d 1975- |e VerfasserIn |0 (DE-588)12346000X |0 (DE-627)082568081 |0 (DE-576)293718016 |4 aut | |
| 700 | 1 | |8 4\p |a Pahl, Heike L. |d 1966- |e VerfasserIn |0 (DE-588)12022772X |0 (DE-627)696480433 |0 (DE-576)292110057 |4 aut | |
| 700 | 1 | |a Béliveau, François |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hébert, Josée |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lehnertz, Bernhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sauvageau, Guy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Menendez, Pablo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cabezas Wallscheid, Nina |d 1982- |e VerfasserIn |0 (DE-588)141488085 |0 (DE-627)62942862X |0 (DE-576)324105959 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood advances |d Washington, DC : American Society of Hematology, 2016 |g 7(2023), 24, Seite 7525-7538 |h Online-Ressource |w (DE-627)873588312 |w (DE-600)2876449-3 |w (DE-576)48043249X |x 2473-9537 |7 nnas |a GPRC5C drives branched-chain amino acid metabolism in leukemogenesis |
| 773 | 1 | 8 | |g volume:7 |g year:2023 |g number:24 |g pages:7525-7538 |g extent:14 |a GPRC5C drives branched-chain amino acid metabolism in leukemogenesis |
| 856 | 4 | 0 | |u https://doi.org/10.1182/bloodadvances.2023010460 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 990 | |a G-Protein gekoppelter Rezeptor | ||
| 992 | |a 20241212 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1207477311 |a Renders, Simon |m 1207477311:Renders, Simon |d 910000 |d 910100 |e 910000PR1207477311 |e 910100PR1207477311 |k 0/910000/ |k 1/910000/910100/ |p 18 | ||
| 999 | |a KXP-PPN1912202077 |e 4635157857 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"December 26 2023"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"relHost":[{"recId":"873588312","pubHistory":["Vol. 1, iss. 1 (November 2016)-"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"[2016]-","publisherPlace":"Washington, DC","publisher":"American Society of Hematology"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["American Society of Hematology"]},"part":{"text":"7(2023), 24, Seite 7525-7538","volume":"7","issue":"24","extent":"14","year":"2023","pages":"7525-7538"},"note":["Gesehen am 27.04.21"],"disp":"GPRC5C drives branched-chain amino acid metabolism in leukemogenesisBlood advances","title":[{"title_sort":"Blood advances","title":"Blood advances"}],"id":{"zdb":["2876449-3"],"eki":["873588312"],"issn":["2473-9537"]}}],"name":{"displayForm":["Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau, Josée Hébert, Bernhard Lehnertz, Guy Sauvageau, Pablo Menendez, and Nina Cabezas-Wallscheid"]},"person":[{"given":"Yu Wei","role":"aut","display":"Zhang, Yu Wei","roleDisplay":"VerfasserIn","family":"Zhang"},{"family":"Velasco-Hernandez","roleDisplay":"VerfasserIn","role":"aut","display":"Velasco-Hernandez, Talia","given":"Talia"},{"display":"Mess, Julian","role":"aut","given":"Julian","family":"Mess","roleDisplay":"VerfasserIn"},{"given":"Maria-Eleni","display":"Lalioti, Maria-Eleni","role":"aut","family":"Lalioti","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Romero-Mulero, Mari Carmen","given":"Mari Carmen","roleDisplay":"VerfasserIn","family":"Romero-Mulero"},{"display":"Obier, Nadine","role":"aut","given":"Nadine","family":"Obier","roleDisplay":"VerfasserIn"},{"family":"Karantzelis","roleDisplay":"VerfasserIn","given":"Nikolaos","role":"aut","display":"Karantzelis, Nikolaos"},{"given":"Jasmin","display":"Rettkowski, Jasmin","role":"aut","roleDisplay":"VerfasserIn","family":"Rettkowski"},{"family":"Schönberger","roleDisplay":"VerfasserIn","display":"Schönberger, Katharina","role":"aut","given":"Katharina"},{"given":"Noémie","role":"aut","display":"Karabacz, Noémie","roleDisplay":"VerfasserIn","family":"Karabacz"},{"role":"aut","display":"Jäcklein, Karin","given":"Karin","roleDisplay":"VerfasserIn","family":"Jäcklein"},{"role":"aut","display":"Morishima, Tatsuya","given":"Tatsuya","roleDisplay":"VerfasserIn","family":"Morishima"},{"family":"Trincado","roleDisplay":"VerfasserIn","display":"Trincado, Juan Luis","role":"aut","given":"Juan Luis"},{"roleDisplay":"VerfasserIn","family":"Romecin","role":"aut","display":"Romecin, Paola","given":"Paola"},{"given":"Alba","role":"aut","display":"Martinez, Alba","family":"Martinez","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Takizawa","given":"Hitoshi","display":"Takizawa, Hitoshi","role":"aut"},{"given":"Khalid","display":"Shoumariyeh, Khalid","role":"aut","family":"Shoumariyeh","roleDisplay":"VerfasserIn"},{"family":"Renders","roleDisplay":"VerfasserIn","given":"Simon","role":"aut","display":"Renders, Simon"},{"role":"aut","display":"Zeiser, Robert","given":"Robert","roleDisplay":"VerfasserIn","family":"Zeiser"},{"roleDisplay":"VerfasserIn","family":"Pahl","role":"aut","display":"Pahl, Heike L.","given":"Heike L."},{"roleDisplay":"VerfasserIn","family":"Béliveau","given":"François","role":"aut","display":"Béliveau, François"},{"display":"Hébert, Josée","role":"aut","given":"Josée","family":"Hébert","roleDisplay":"VerfasserIn"},{"family":"Lehnertz","roleDisplay":"VerfasserIn","display":"Lehnertz, Bernhard","role":"aut","given":"Bernhard"},{"display":"Sauvageau, Guy","role":"aut","given":"Guy","roleDisplay":"VerfasserIn","family":"Sauvageau"},{"role":"aut","display":"Menendez, Pablo","given":"Pablo","roleDisplay":"VerfasserIn","family":"Menendez"},{"role":"aut","display":"Cabezas Wallscheid, Nina","given":"Nina","roleDisplay":"VerfasserIn","family":"Cabezas Wallscheid"}],"physDesc":[{"noteIll":"Illustrationen, Diagramme","extent":"14 S."}],"note":["Gesehen am 12.12.2024"],"recId":"1912202077","id":{"doi":["10.1182/bloodadvances.2023010460"],"eki":["1912202077"]},"title":[{"title_sort":"GPRC5C drives branched-chain amino acid metabolism in leukemogenesis","title":"GPRC5C drives branched-chain amino acid metabolism in leukemogenesis"}]} | ||
| SRT | |a ZHANGYUWEIGPRC5CDRIV2620 | ||