Comparison of two autologous hematopoietic stem cell mobilization strategies in patients with multiple myeloma: CE plus G-CSF versus G-CSF only: a single-center retrospective analysis
Background Despite recent advances in the treatment of multiple myeloma, high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) remains an essential therapeutic keystone. As for the stem cell mobilization procedure, different regimens have been established, usua...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2024
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| In: |
Transfusion
Year: 2024, Jahrgang: 64, Heft: 5, Pages: 871-880 |
| ISSN: | 1537-2995 |
| DOI: | 10.1111/trf.17829 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/trf.17829 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.17829 
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| Verfasserangaben: | Veronika Dill, Philipp Blüm, Anja Lindemann, Alexander Biederstädt, Marion Högner, Katharina S. Götze, Florian Bassermann, Martin Hildebrandt |
MARC
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| 245 | 1 | 0 | |a Comparison of two autologous hematopoietic stem cell mobilization strategies in patients with multiple myeloma |b CE plus G-CSF versus G-CSF only: a single-center retrospective analysis |c Veronika Dill, Philipp Blüm, Anja Lindemann, Alexander Biederstädt, Marion Högner, Katharina S. Götze, Florian Bassermann, Martin Hildebrandt |
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| 520 | |a Background Despite recent advances in the treatment of multiple myeloma, high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) remains an essential therapeutic keystone. As for the stem cell mobilization procedure, different regimens have been established, usually consisting of a cycle of chemotherapy followed by application of granulocyte-colony stimulating factor (G-CSF), although febrile neutropenia is a common complication. Following national guidelines, our institution decided to primarily use G-CSF only mobilization during the COVID-19 pandemic to minimize the patients' risk of infection and to reduce the burden on the health system. Study Design and Methods In this retrospective single-center analysis, the efficacy and safety of G-CSF only mobilization was evaluated and compared to a historic control cohort undergoing chemotherapy-based mobilization by cyclophosphamide and etoposide (CE) plus G-CSF. Results Although G-CSF only was associated with a higher need for plerixafor administration (p < .0001) and a higher number of apheresis sessions per patient (p = .0002), we were able to collect the target dose of hematopoietic stem cells in the majority of our patients. CE mobilization achieved higher hematopoietic stem cell yields (p = .0015) and shorter apheresis sessions (p < .0001) yet was accompanied by an increased risk of febrile neutropenia (p < .0001). There was no difference in engraftment after ASCT. Discussion G-CSF only mobilization is a useful option in selected patients with comorbidities and an increased risk of serious infections, especially in the wintertime or in future pandemics. | ||
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a G-CSF | |
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| 650 | 4 | |a multiple myeloma | |
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| 700 | 1 | |a Blüm, Philipp |e VerfasserIn |0 (DE-588)1344991505 |0 (DE-627)1905725485 |4 aut | |
| 700 | 1 | |a Lindemann, Anja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Biederstädt, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Högner, Marion |e VerfasserIn |4 aut | |
| 700 | 1 | |a Götze, Katharina S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bassermann, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hildebrandt, Martin |e VerfasserIn |4 aut | |
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