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Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients

Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resi...

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Main Authors: Wang, Justin Z. (Author) , Landry, Alexander P. (Author) , Raleigh, David R. (Author) , Sahm, Felix (Author) , Walsh, Kyle M. (Author) , Goldbrunner, Roland (Author) , Yefet, Leeor S. (Author) , Tonn, Jörg-Christian (Author) , Gui, Chloe (Author) , Ostrom, Quinn T. (Author) , Barnholtz-Sloan, Jil (Author) , Perry, Arie (Author) , Ellenbogen, Yosef (Author) , Hanemann, C. Oliver (Author) , Jungwirth, Gerhard (Author) , Jenkinson, Michael D. (Author) , Tabatabai, Ghazaleh (Author) , Mathiesen, Tiit (Author) , McDermott, Michael W. (Author) , Tatagiba, Marcos (Author) , La Fougère, Christian Jean (Author) , Maas, Sybren L. N. (Author) , Galldiks, Norbert (Author) , Albert, Nathalie (Author) , Brastianos, Priscilla K. (Author) , Ehret, Felix (Author) , Minniti, Giuseppe (Author) , Lamszus, Katrin (Author) , Ricklefs, Franz Lennard (Author) , Schittenhelm, Jens Florian (Author) , Drummond, Katharine J. (Author) , Dunn, Ian F. (Author) , Pathmanaban, Omar N. (Author) , Cohen-Gadol, Aaron A. (Author) , Sulman, Erik P. (Author) , Tabouret, Emeline (Author) , Rhun, Emelie Le (Author) , Mawrin, Christian (Author) , Moliterno, Jennifer (Author) , Weller, Michael (Author) , Bi, Wenya Linda (Author) , Gao, Andrew (Author) , Yip, Stephen (Author) , Niyazi, Karim-Maximilian (Author) , Aldape, Kenneth (Author) , Wen, Patrick Y. (Author) , Short, Susan C. (Author) , Preusser, Matthias (Author) , Nassiri, Farshad (Author) , Zadeh, Gelareh (Author)
Format: Article (Journal)
Language:English
Published: October 2024
In: Neuro-Oncology
Year: 2024, Volume: 26, Issue: 10, Pages: 1742-1780
ISSN:1523-5866
DOI:10.1093/neuonc/noae082
Online Access:Verlag, kostenfrei, Volltext: https://dx.doi.org/10.1093/neuonc/noae082
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Author Notes: Justin Z. Wang , Alexander P. Landry , David R. Raleigh , Felix Sahm , Kyle M. Walsh , Roland Goldbrunner , Leeor S. Yefet , Jörg C. Tonn , Chloe Gui , Quinn T. Ostrom , Jill Barnholtz-Sloan , Arie Perry , Yosef Ellenbogen , C. Oliver Hanemann , Gerhard Jungwirth , [und 35 weitere]
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Summary:Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resistance, resulting in significant neurologic morbidity and even mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication. However, unlike other central nervous system (CNS) tumors, a unified molecular taxonomy for meningiomas has not yet been established and remains an overarching goal of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official World Health Organization (cIMPACT-NOW) working group. Additionally, clinical equipoise still remains on how specific meningioma cases and patient populations should be optimally managed. To address these existing gaps, members of the International Consortium on Meningiomas including field-leading experts, have prepared this comprehensive consensus narrative review directed toward clinicians, researchers, and patients. Included in this manuscript are detailed overviews of proposed molecular classifications, novel biomarkers, contemporary treatment strategies, trials on systemic therapies, health-related quality-of-life studies, and management strategies for unique meningioma patient populations. In each section, we discuss the current state of knowledge as well as ongoing clinical and research challenges to road map future directions for further investigation.
Item Description:Online veröffentlicht: 2. Mai 2024, Korrektur und Schriftsatz: 17. Juli 2024
Gesehen am 08.05.2025
Physical Description:Online Resource
ISSN:1523-5866
DOI:10.1093/neuonc/noae082

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