Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-stranded DNA (dsDNA) links environmental stimuli and inflammation. We hypothesized that nit...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2024
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| In: |
Pediatric research
Year: 2024, Pages: 1-7 |
| ISSN: | 1530-0447 |
| DOI: | 10.1038/s41390-024-03277-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41390-024-03277-2 Verlag, lizenzpflichtig, Volltext: http://www.nature.com/articles/s41390-024-03277-2 
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| Verfasserangaben: | Moritz Markel, Wai Hei Tse, Nolan De Leon, Marietta Jank, Jaida Albrechtsen, Shana Kahnamoui Zadeh, Daywin Patel, Arzu Ozturk, Martin Lacher, Richard Wagner and Richard Keijzer |
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| 520 | |a The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-stranded DNA (dsDNA) links environmental stimuli and inflammation. We hypothesized that nitrofen exposure alters cGAS and STING in human bronchial epithelial cells and fetal rat lungs. | ||
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