Investigation of inert gas washout methods in a new numerical model based on an electrical analogy
Inert gas washout methods have been shown to detect pathological changes in the small airways that occur in the early stages of obstructive lung diseases such as asthma and COPD. Numerical lung models support the analysis of characteristic washout curves, but are limited in their ability to simulate...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2025
|
| In: |
Medical & biological engineering & computing
Year: 2025, Volume: 63, Issue: 2, Pages: 447-466 |
| ISSN: | 1741-0444 |
| DOI: | 10.1007/s11517-024-03200-1 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11517-024-03200-1
|
| Author Notes: | Christoph Schmidt, Wasilios Hatziklitiu, Frederik Trinkmann, Giorgio Cattaneo, Johannes Port |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1913636291 | ||
| 003 | DE-627 | ||
| 005 | 20260126110119.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250107s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11517-024-03200-1 |2 doi | |
| 035 | |a (DE-627)1913636291 | ||
| 035 | |a (DE-599)KXP1913636291 | ||
| 035 | |a (OCoLC)1528015742 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmidt, Christoph |e VerfasserIn |0 (DE-588)1304723631 |0 (DE-627)1860628451 |4 aut | |
| 245 | 1 | 0 | |a Investigation of inert gas washout methods in a new numerical model based on an electrical analogy |c Christoph Schmidt, Wasilios Hatziklitiu, Frederik Trinkmann, Giorgio Cattaneo, Johannes Port |
| 264 | 1 | |c February 2025 | |
| 300 | |a 20 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 07. Oktober 2024 | ||
| 500 | |a Gesehen am 07.01.2025 | ||
| 520 | |a Inert gas washout methods have been shown to detect pathological changes in the small airways that occur in the early stages of obstructive lung diseases such as asthma and COPD. Numerical lung models support the analysis of characteristic washout curves, but are limited in their ability to simulate the complexity of lung anatomy over an appropriate time period. Therefore, the interpretation of patient-specific washout data remains a challenge. A new numerical lung model is presented in which electrical components describe the anatomical and physiological characteristics of the lung as well as gas-specific properties. To verify that the model is able to reproduce characteristic washout curves, the phase 3 slopes (S3) of helium washouts are simulated using simple asymmetric lung anatomies consisting of two parallel connected lung units with volume ratios of frac{1.25}{\mathrm{0.75}}, frac{1.50}{\mathrm{0.50}}, and {1.75}{\mathrm{0.25}} and a total volume flow of 250 ml/s which are evaluated for asymmetries in both the convection- and diffusion-dominated zone of the lung. The results show that the model is able to reproduce the S3 for helium and thus the processes underlying the washout methods, so that electrical components can be used to model these methods. This approach could form the basis of a hardware-based real-time simulator. | ||
| 650 | 4 | |a Compartment model | |
| 650 | 4 | |a Convection | |
| 650 | 4 | |a Diffusion | |
| 650 | 4 | |a Electrical analogy | |
| 650 | 4 | |a Lung model | |
| 650 | 4 | |a Multibreath washout | |
| 700 | 1 | |a Hatziklitiu, Wasilios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trinkmann, Frederik |d 1983- |e VerfasserIn |0 (DE-588)142731773 |0 (DE-627)704298066 |0 (DE-576)332907406 |4 aut | |
| 700 | 1 | |a Cattaneo, Giorgio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Port, Johannes |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medical & biological engineering & computing |d Cham : Springer Nature, 1963 |g 63(2025), 2 vom: Feb., Seite 447-466 |h Online-Ressource |w (DE-627)331747456 |w (DE-600)2052667-2 |w (DE-576)273651145 |x 1741-0444 |7 nnas |a Investigation of inert gas washout methods in a new numerical model based on an electrical analogy |
| 773 | 1 | 8 | |g volume:63 |g year:2025 |g number:2 |g month:02 |g pages:447-466 |g extent:20 |a Investigation of inert gas washout methods in a new numerical model based on an electrical analogy |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s11517-024-03200-1 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20250107 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 142731773 |a Trinkmann, Frederik |m 142731773:Trinkmann, Frederik |d 60000 |d 61000 |d 60000 |e 60000PT142731773 |e 61000PT142731773 |e 60000PT142731773 |k 0/60000/ |k 1/60000/61000/ |k 0/60000/ |p 3 | ||
| 999 | |a KXP-PPN1913636291 |e 4645466585 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"note":["Online veröffentlicht: 07. Oktober 2024","Gesehen am 07.01.2025"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"February 2025","dateIssuedKey":"2025"}],"title":[{"title_sort":"Investigation of inert gas washout methods in a new numerical model based on an electrical analogy","title":"Investigation of inert gas washout methods in a new numerical model based on an electrical analogy"}],"person":[{"family":"Schmidt","display":"Schmidt, Christoph","role":"aut","given":"Christoph"},{"role":"aut","given":"Wasilios","display":"Hatziklitiu, Wasilios","family":"Hatziklitiu"},{"role":"aut","given":"Frederik","display":"Trinkmann, Frederik","family":"Trinkmann"},{"display":"Cattaneo, Giorgio","family":"Cattaneo","given":"Giorgio","role":"aut"},{"display":"Port, Johannes","family":"Port","role":"aut","given":"Johannes"}],"id":{"doi":["10.1007/s11517-024-03200-1"],"eki":["1913636291"]},"relHost":[{"disp":"Investigation of inert gas washout methods in a new numerical model based on an electrical analogyMedical & biological engineering & computing","corporate":[{"display":"International Federation for Medical and Biological Engineering","role":"isb"}],"part":{"text":"63(2025), 2 vom: Feb., Seite 447-466","pages":"447-466","year":"2025","volume":"63","extent":"20","issue":"2"},"note":["Gesehen am 27.05.2022"],"title":[{"title_sort":"Medical & biological engineering & computing","title":"Medical & biological engineering & computing"}],"origin":[{"dateIssuedDisp":"1963-","publisherPlace":"Cham","publisher":"Springer Nature","dateIssuedKey":"1963"}],"titleAlt":[{"title":"Medical and biological engineering & computing"},{"title":"Medical electronics and biological engineering"},{"title":"Medical & biological engineering"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["International Federation for Medical and Biological Engineering"]},"recId":"331747456","pubHistory":["1.1963 -"],"id":{"issn":["1741-0444"],"eki":["331747456"],"zdb":["2052667-2"]}}],"recId":"1913636291","physDesc":[{"extent":"20 S."}],"name":{"displayForm":["Christoph Schmidt, Wasilios Hatziklitiu, Frederik Trinkmann, Giorgio Cattaneo, Johannes Port"]}} | ||
| SRT | |a SCHMIDTCHRINVESTIGAT2025 | ||