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Genetic alterations in myeloproliferative and myelodysplastic/myeloproliferative neoplasms: a practical guide to WHO-HAEM5

Within the World Health Organization (WHO) classification of haematopoietic neoplasms, particularly its fifth version from 2022 (WHO-HAEM5), myeloid neoplasms are not only grouped into myeloproliferative (MPN) and myelodysplastic neoplasms (MDS). There is also a group of haematological disorders tha...

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Main Authors: Kühn, Constanze (Author) , Hörst, Katharina (Author) , Kvasnicka, Hans M. (Author) , Hochhaus, Andreas (Author) , Reiter, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 6. März 2024
In: Medizinische Genetik
Year: 2024, Volume: 36, Issue: 1, Pages: 31-38
ISSN:1863-5490
DOI:10.1515/medgen-2024-2003
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1515/medgen-2024-2003
Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/medgen-2024-2003/html
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Author Notes:Constanze Kühn, Katharina Hörst, Hans M. Kvasnicka, Andreas Hochhaus, Andreas Reiter

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520 |a Within the World Health Organization (WHO) classification of haematopoietic neoplasms, particularly its fifth version from 2022 (WHO-HAEM5), myeloid neoplasms are not only grouped into myeloproliferative (MPN) and myelodysplastic neoplasms (MDS). There is also a group of haematological disorders that share features of both categories termed myelodysplastic /myeloproliferative neoplasms (MDS/MPN). In this article, we aim to provide a comprehensive and practical guide to WHO-HAEM5 highlighting the genetic alterations that underlie MPN and MDS/MPN. This guide provides an overview of the overlapping commonalities among these entities, as well as their unique characteristics. 
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