Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care center
Background/Aim: Systemic treatment for metastatic colorectal cancer (CRC) includes chemotherapy in combination with a targeted antibody. Novel targeted therapies and immunotherapies are introduced for specific molecular subgroups. Prognostic relevant determinants are still under investigation. Patie...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2023
|
| In: |
Anticancer research
Year: 2023, Jahrgang: 43, Heft: 12, Pages: 5589-5596 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.16761 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.16761 Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/43/12/5589/tab-article-info 
|
| Verfasserangaben: | Xin-Wen Zhang, Jutta Mohr, Niels Halama and Ronald Koschny |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1913793818 | ||
| 003 | DE-627 | ||
| 005 | 20250716221149.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250108s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.16761 |2 doi | |
| 035 | |a (DE-627)1913793818 | ||
| 035 | |a (DE-599)KXP1913793818 | ||
| 035 | |a (OCoLC)1528015795 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zhang, Xin-Wen |d 1995- |e VerfasserIn |0 (DE-588)1236696883 |0 (DE-627)1762469553 |4 aut | |
| 245 | 1 | 0 | |a Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care center |c Xin-Wen Zhang, Jutta Mohr, Niels Halama and Ronald Koschny |
| 264 | 1 | |c December 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.01.2025 | ||
| 500 | |a Online veröffentlicht: 29. November 2023 | ||
| 520 | |a Background/Aim: Systemic treatment for metastatic colorectal cancer (CRC) includes chemotherapy in combination with a targeted antibody. Novel targeted therapies and immunotherapies are introduced for specific molecular subgroups. Prognostic relevant determinants are still under investigation. Patients and Methods: Systemic therapies of an unselected patient cohort with metastatic CRC were retrospectively analyzed. Treatment outcome was evaluated according to time-to-next-treatment (TTNT) and frequency of conversion surgery and compared between subgroups stratified by primary tumor side, molecular profile, sex and age, and metastases sites. Results: More than 50% of patients with locally advanced or metastatic CRC underwent secondary resection after first-line systemic therapy. Rectum carcinoma had the best prognosis under anti-EGFR-antibody treatment. Female patients had a worse prognosis than male patients in late disease stage. Young patients demonstrated poor response to systemic therapy, but a high rate of conversion surgeries. Conversely, elderly patients benefited from systemic therapy but underwent surgery less frequently. Liver and lung metastases had a worse prognosis than other metastases sites, whereas lung metastases were more likely to be resected than liver metastases in early disease stage. Conclusion: Patient age, sex, primary tumor localization, and metastatic sites are prognostic factors that could guide future treatment decisions for the therapy of metastatic CRC. | ||
| 650 | 4 | |a BEVACIZUMAB | |
| 650 | 4 | |a CANCER | |
| 650 | 4 | |a chemotherapy | |
| 650 | 4 | |a CHEMOTHERAPY | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a colorectal liver metastases | |
| 650 | 4 | |a metastases | |
| 650 | 4 | |a PLUS CETUXIMAB | |
| 650 | 4 | |a secondary surgery | |
| 650 | 4 | |a THERAPY | |
| 650 | 4 | |a time-to-next-treatment | |
| 650 | 4 | |a TRIALS | |
| 650 | 4 | |a tumor sidedness | |
| 700 | 1 | |a Mohr, Jutta |e VerfasserIn |0 (DE-588)1333422709 |0 (DE-627)1891518542 |4 aut | |
| 700 | 1 | |a Halama, Niels |d 1977- |e VerfasserIn |0 (DE-588)13087325X |0 (DE-627)507228723 |0 (DE-576)251045706 |4 aut | |
| 700 | 1 | |a Koschny, Ronald |d 1974- |e VerfasserIn |0 (DE-588)124377483 |0 (DE-627)70661836X |0 (DE-576)185833950 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 43(2023), 12, Seite 5589-5596 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care center |
| 773 | 1 | 8 | |g volume:43 |g year:2023 |g number:12 |g pages:5589-5596 |g extent:8 |a Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care center |
| 856 | 4 | 0 | |u https://doi.org/10.21873/anticanres.16761 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://ar.iiarjournals.org/content/43/12/5589/tab-article-info |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250108 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 124377483 |a Koschny, Ronald |m 124377483:Koschny, Ronald |d 910000 |d 910100 |d 50000 |e 910000PK124377483 |e 910100PK124377483 |e 50000PK124377483 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 4 |y j | ||
| 998 | |g 13087325X |a Halama, Niels |m 13087325X:Halama, Niels |d 50000 |e 50000PH13087325X |k 0/50000/ |p 3 | ||
| 998 | |g 1236696883 |a Zhang, Xin-Wen |m 1236696883:Zhang, Xin-Wen |d 910000 |d 910100 |e 910000PZ1236696883 |e 910100PZ1236696883 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1913793818 |e 4646831317 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care center","title":"Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care center"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"noteIll":"Illustrationen","extent":"8 S."}],"id":{"eki":["1913793818"],"doi":["10.21873/anticanres.16761"]},"relHost":[{"disp":"Analysis of an unselected patient cohort with advanced colorectal carcinoma from a maximum care centerAnticancer research","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"part":{"volume":"43","year":"2023","pages":"5589-5596","extent":"8","issue":"12","text":"43(2023), 12, Seite 5589-5596"},"note":["Gesehen am 26.02.13"],"pubHistory":["Nachgewiesen 24.2004 -"],"title":[{"title_sort":"Anticancer research","title":"Anticancer research","subtitle":"international journal of cancer research and treatment"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1791-7530"],"eki":["387478493"],"zdb":["2145376-7"]},"origin":[{"publisherPlace":"Kapandriti, Attiki, Greece","dateIssuedKey":"2004","dateIssuedDisp":"2004-","publisher":"International Institute of Anticancer Research"}],"name":{"displayForm":["International Institute of Anticancer Research"]},"recId":"387478493"}],"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"December 2023"}],"language":["eng"],"name":{"displayForm":["Xin-Wen Zhang, Jutta Mohr, Niels Halama and Ronald Koschny"]},"person":[{"role":"aut","family":"Zhang","given":"Xin-Wen","display":"Zhang, Xin-Wen"},{"given":"Jutta","display":"Mohr, Jutta","role":"aut","family":"Mohr"},{"role":"aut","family":"Halama","display":"Halama, Niels","given":"Niels"},{"display":"Koschny, Ronald","given":"Ronald","role":"aut","family":"Koschny"}],"recId":"1913793818","note":["Gesehen am 08.01.2025","Online veröffentlicht: 29. November 2023"]} | ||
| SRT | |a ZHANGXINWEANALYSISOF2023 | ||