Longitudinal associations of polypharmacy and frailty with major cardiovascular events and mortality among more than half a million middle-aged participants of the UK Biobank
Background - Studies of the associations of polypharmacy and frailty with adverse health outcomes in middle-aged adults are limited. Furthermore, a potentially stronger association of polypharmacy with adverse health outcomes in frail than in non-frail adults is of interest. - Objective - To evaluat...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2024
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| In: |
Maturitas
Year: 2024, Jahrgang: 185, Pages: [1]-9 |
| ISSN: | 1873-4111 |
| DOI: | 10.1016/j.maturitas.2024.107998 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.maturitas.2024.107998 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0378512224000938 
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| Verfasserangaben: | Li-Ju Chen, Sha Sha, Hermann Brenner, Ben Schöttker |
MARC
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| 520 | |a Background - Studies of the associations of polypharmacy and frailty with adverse health outcomes in middle-aged adults are limited. Furthermore, a potentially stronger association of polypharmacy with adverse health outcomes in frail than in non-frail adults is of interest. - Objective - To evaluate associations of frailty (assessed using a frailty index) and polypharmacy (defined as taking five or more drugs) with major cardiovascular events, cancer incidence, all-cause, cardiovascular disease-specific, and cancer-specific mortality. - Methods - Cox proportional hazards regression models were used to analyze 501,548 participants of the UK Biobank cohort study aged 40-69 years who were followed up for an average of 12 years. - Results - The prevalence of pre-frailty and frailty were 43.2 % and 2.3 %, respectively, and that of polypharmacy was 18.3 %. Although strongly associated with each other, frailty and polypharmacy were independently, statistically significantly associated with major cardiovascular events, cardiovascular disease-specific, and all-cause mortality. In addition, the hazard ratios of polypharmacy were stronger among (pre-)frail than non-frail study participants. No profound associations with cancer incidence and cancer mortality were observed. No sex and age differences were observed. - Conclusions - This large cohort study showed that polypharmacy and frailty are independent risk factors for major cardiovascular events, cardiovascular disease-specific and all-cause mortality in both middle-aged (40-64 years) and older people (≥ 65 years). In addition, the hazard ratios of polypharmacy were stronger among (pre-)frail than non-frail study participants. This underlines the need to avoid polypharmacy as far as possible not only in older but also in middle-aged subjects (40-64 years), especially if they are pre-frail or frail. | ||
| 650 | 4 | |a Cardiovascular disease mortality | |
| 650 | 4 | |a Frailty | |
| 650 | 4 | |a MACE | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Polypharmacy | |
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