Calculating future 10-year breast cancer risks in risk-adapted surveillance: a method comparison and application in clinical practice
The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has successfully implemented risk-adapted breast cancer surveillance for women at high breast cancer risk in Germany. Women with a family history of breast and ovarian cancer but without pathogenic germline variants in recogniz...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 22, 2024
|
| In: |
Cancer Prevention Research
Year: 2025, Jahrgang: 18, Heft: 2, Pages: 85-92 |
| ISSN: | 1940-6215 |
| DOI: | 10.1158/1940-6207.CAPR-24-0328 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1158/1940-6207.CAPR-24-0328 Resolving-System, kostenfrei: https://doi.org/10.25673/118313 
|
| Verfasserangaben: | $hSilke Zachariae, Anne S. Quante, Marion Kiechle, Kerstin Rhiem, Tanja N. Fehm, Jörg-Gunther Schröder, Judit Horvath, Elena Leinert, Nicola Dikow, Joelle Ronez, Mirjam Schönfeld, Marion T. van Mackelenbergh, Ulrich A. Schatz, Cornelia Meisel, Bahriye Aktas, Dennis Witt, Yasmin Mehraein, Bernhard H.F. Weber, Christine Solbach, Dorothee Speiser, Juliane Hoyer, Gesine Faigle-Krehl, Christiane D. Much, Alma-Verena Müller-Rausch, Pablo Villavicencio-Lorini, Maggie Banys-Paluchowski, Daniel Pieh, Rita K. Schmutzler, Christine Fischer and Christoph Engel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 191390508X | ||
| 003 | DE-627 | ||
| 005 | 20251127232833.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250109s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1158/1940-6207.CAPR-24-0328 |2 doi | |
| 024 | 7 | |a 10.25673/118313 |2 doi | |
| 035 | |a (DE-627)191390508X | ||
| 035 | |a (DE-599)KXP191390508X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zachariae, Silke |d 1977- |e VerfasserIn |0 (DE-588)134168224 |0 (DE-627)692144579 |0 (DE-576)300353715 |4 aut | |
| 245 | 1 | 0 | |a Calculating future 10-year breast cancer risks in risk-adapted surveillance |b a method comparison and application in clinical practice |c $hSilke Zachariae, Anne S. Quante, Marion Kiechle, Kerstin Rhiem, Tanja N. Fehm, Jörg-Gunther Schröder, Judit Horvath, Elena Leinert, Nicola Dikow, Joelle Ronez, Mirjam Schönfeld, Marion T. van Mackelenbergh, Ulrich A. Schatz, Cornelia Meisel, Bahriye Aktas, Dennis Witt, Yasmin Mehraein, Bernhard H.F. Weber, Christine Solbach, Dorothee Speiser, Juliane Hoyer, Gesine Faigle-Krehl, Christiane D. Much, Alma-Verena Müller-Rausch, Pablo Villavicencio-Lorini, Maggie Banys-Paluchowski, Daniel Pieh, Rita K. Schmutzler, Christine Fischer and Christoph Engel |
| 264 | 1 | |c November 22, 2024 | |
| 300 | |b Diagramme | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.10.2025 | ||
| 520 | |a The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has successfully implemented risk-adapted breast cancer surveillance for women at high breast cancer risk in Germany. Women with a family history of breast and ovarian cancer but without pathogenic germline variants in recognized breast cancer risk genes are recommended annual breast imaging if their predicted 10-year breast cancer risk is 5% or higher, using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) breast cancer risk model, as outlined in the current GC-HBOC guideline. However, women who initially do not meet this risk threshold may do so later, even if there is no new cancer in their family. To determine when this threshold is crossed, one could annually repeat BOADICEA calculations using an aging pedigree: the “prediction by aging pedigree” (AP) approach. Alternatively, we propose a simplified and more practical “'conditional probability” (CP) approach, which calculates future risks based on the initial BOADICEA assessment. Using data from 6,661 women registered with GC-HBOC, both methods were compared. Initially, 74% of women, ages 30 to 48 years, had a 10-year breast cancer risk below 5%, but 53% exceeded this threshold at an older age based on the AP approach. Among the women with an initial risk below the threshold, the CP approach revealed that 99% of women exceeded the 5% threshold at the same or an earlier age compared with the AP approach (88% of cases were within the same year or 1 year earlier). The CP approach has been implemented as a user-friendly web application. | ||
| 540 | |q DE-3 |a Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |f CC BY-NC-ND 4.0 |2 cc |u https://creativecommons.org/licenses/by-nc-nd/4.0/ | ||
| 700 | 1 | |a Quante, Anne Siobhain |d 1977- |e VerfasserIn |0 (DE-588)130261378 |0 (DE-627)496580213 |0 (DE-576)298093731 |4 aut | |
| 700 | 1 | |a Kiechle, Marion |d 1960- |e VerfasserIn |0 (DE-588)122531949 |0 (DE-627)082000034 |0 (DE-576)174787405 |4 aut | |
| 700 | 1 | |a Rhiem, Kerstin E. M. |d 1970- |e VerfasserIn |0 (DE-588)122553454 |0 (DE-627)082013497 |0 (DE-576)293320756 |4 aut | |
| 700 | 1 | |a Fehm, Tanja |d 1971- |e VerfasserIn |0 (DE-588)120391759 |0 (DE-627)080645690 |0 (DE-576)292194064 |4 aut | |
| 700 | 1 | |a Schröder, Jörg-Gunther |e VerfasserIn |4 aut | |
| 700 | 1 | |a Horvath, Judit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leinert, Elena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dikow, Nicola |e VerfasserIn |0 (DE-588)1073294196 |0 (DE-627)82881726X |0 (DE-576)434859397 |4 aut | |
| 700 | 1 | |a Ronez, Joelle |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schönfeld, Mirjam |d 1980- |e VerfasserIn |0 (DE-588)135954401 |0 (DE-627)57339850X |0 (DE-576)300742703 |4 aut | |
| 700 | 1 | |a Mackelenbergh, Marion Tina van |d 1981- |e VerfasserIn |0 (DE-588)133221520 |0 (DE-627)691253633 |0 (DE-576)299705056 |4 aut | |
| 700 | 1 | |a Schatz, Ulrich A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meisel, Cornelia |e VerfasserIn |0 (DE-588)1172239177 |0 (DE-627)104104898X |0 (DE-576)514446099 |4 aut | |
| 700 | 1 | |a Aktaş, Bahriye |d 1975- |e VerfasserIn |0 (DE-588)130405736 |0 (DE-627)501115072 |0 (DE-576)298175576 |4 aut | |
| 700 | 1 | |a Witt, Dennis |d 1990- |e VerfasserIn |0 (DE-588)1278626018 |0 (DE-627)1831536382 |4 aut | |
| 700 | 1 | |a Mehraein, Yasmin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weber, Bernhard H. F. |e VerfasserIn |0 (DE-588)1061058050 |0 (DE-627)80383795X |0 (DE-576)417180810 |4 aut | |
| 700 | 1 | |a Solbach, Christine |e VerfasserIn |0 (DE-588)124330266 |0 (DE-627)085790524 |0 (DE-576)29412277X |4 aut | |
| 700 | 1 | |a Speiser, Dorothee |e VerfasserIn |0 (DE-588)1188844482 |0 (DE-627)1667737260 |4 aut | |
| 700 | 1 | |a Hoyer, Juliane |e VerfasserIn |0 (DE-588)116634682X |0 (DE-627)1030380163 |0 (DE-576)51072860X |4 aut | |
| 700 | 1 | |a Faigle-Krehl, Gesine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Much, Christiane Dörte |d 1989- |e VerfasserIn |0 (DE-588)1242747591 |0 (DE-627)1772820733 |4 aut | |
| 700 | 1 | |a Müller-Rausch, Alma-Verena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Villavicencio Lorini, Pablo |d 1975- |e VerfasserIn |0 (DE-588)129325945 |0 (DE-627)396449174 |0 (DE-576)297599992 |4 aut | |
| 700 | 1 | |a Banys-Paluchowski, Maggie |d 1984- |e VerfasserIn |0 (DE-588)140695982 |0 (DE-627)620892315 |0 (DE-576)31957427X |4 aut | |
| 700 | 1 | |a Pieh, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmutzler, Rita |e VerfasserIn |0 (DE-588)1186998210 |0 (DE-627)1666283703 |4 aut | |
| 700 | 1 | |8 1\p |a Fischer, Christine |d 1955- |e VerfasserIn |0 (DE-588)128461993 |0 (DE-627)373010362 |0 (DE-576)297159674 |4 aut | |
| 700 | 1 | |8 2\p |a Engel, Christoph |d 1968- |e VerfasserIn |0 (DE-588)121057054 |0 (DE-627)705194213 |0 (DE-576)292520727 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer Prevention Research |d Philadelphia, Pa. : AACR, 2008 |g 18(2025), 2, Seite 85-92 |h Online-Ressource |w (DE-627)564751022 |w (DE-600)2422346-3 |w (DE-576)30737789X |x 1940-6215 |7 nnas |a Calculating future 10-year breast cancer risks in risk-adapted surveillance a method comparison and application in clinical practice |
| 773 | 1 | 8 | |g volume:18 |g year:2025 |g number:2 |g pages:85-92 |g extent:8 |a Calculating future 10-year breast cancer risks in risk-adapted surveillance a method comparison and application in clinical practice |
| 856 | 4 | 0 | |u https://doi.org/10.1158/1940-6207.CAPR-24-0328 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.25673/118313 |x Resolving-System |z kostenfrei |
| 883 | |8 1\p |a cgwrk |d 20251101 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20251101 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20251023 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1073294196 |a Dikow, Nicola |m 1073294196:Dikow, Nicola |d 910000 |d 911500 |e 910000PD1073294196 |e 911500PD1073294196 |k 0/910000/ |k 1/910000/911500/ |p 9 | ||
| 999 | |a KXP-PPN191390508X |e 4791022432 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Zachariae, Silke","role":"aut","given":"Silke","family":"Zachariae"},{"family":"Quante","given":"Anne Siobhain","role":"aut","display":"Quante, Anne Siobhain"},{"family":"Kiechle","role":"aut","given":"Marion","display":"Kiechle, Marion"},{"given":"Kerstin E. M.","role":"aut","family":"Rhiem","display":"Rhiem, Kerstin E. M."},{"display":"Fehm, Tanja","role":"aut","given":"Tanja","family":"Fehm"},{"display":"Schröder, Jörg-Gunther","family":"Schröder","given":"Jörg-Gunther","role":"aut"},{"display":"Horvath, Judit","family":"Horvath","given":"Judit","role":"aut"},{"family":"Leinert","given":"Elena","role":"aut","display":"Leinert, Elena"},{"display":"Dikow, Nicola","family":"Dikow","role":"aut","given":"Nicola"},{"given":"Joelle","role":"aut","family":"Ronez","display":"Ronez, Joelle"},{"role":"aut","given":"Mirjam","family":"Schönfeld","display":"Schönfeld, Mirjam"},{"display":"Mackelenbergh, Marion Tina van","family":"Mackelenbergh","role":"aut","given":"Marion Tina van"},{"family":"Schatz","role":"aut","given":"Ulrich A.","display":"Schatz, Ulrich A."},{"given":"Cornelia","role":"aut","family":"Meisel","display":"Meisel, Cornelia"},{"family":"Aktaş","given":"Bahriye","role":"aut","display":"Aktaş, Bahriye"},{"role":"aut","given":"Dennis","family":"Witt","display":"Witt, Dennis"},{"family":"Mehraein","given":"Yasmin","role":"aut","display":"Mehraein, Yasmin"},{"display":"Weber, Bernhard H. F.","role":"aut","given":"Bernhard H. F.","family":"Weber"},{"display":"Solbach, Christine","family":"Solbach","given":"Christine","role":"aut"},{"display":"Speiser, Dorothee","family":"Speiser","role":"aut","given":"Dorothee"},{"family":"Hoyer","role":"aut","given":"Juliane","display":"Hoyer, Juliane"},{"display":"Faigle-Krehl, Gesine","family":"Faigle-Krehl","role":"aut","given":"Gesine"},{"display":"Much, Christiane Dörte","family":"Much","role":"aut","given":"Christiane Dörte"},{"display":"Müller-Rausch, Alma-Verena","role":"aut","given":"Alma-Verena","family":"Müller-Rausch"},{"display":"Villavicencio Lorini, Pablo","family":"Villavicencio Lorini","given":"Pablo","role":"aut"},{"given":"Maggie","role":"aut","family":"Banys-Paluchowski","display":"Banys-Paluchowski, Maggie"},{"family":"Pieh","role":"aut","given":"Daniel","display":"Pieh, Daniel"},{"display":"Schmutzler, Rita","family":"Schmutzler","role":"aut","given":"Rita"},{"display":"Fischer, Christine","given":"Christine","role":"aut","family":"Fischer"},{"display":"Engel, Christoph","family":"Engel","role":"aut","given":"Christoph"}],"title":[{"title_sort":"Calculating future 10-year breast cancer risks in risk-adapted surveillance","title":"Calculating future 10-year breast cancer risks in risk-adapted surveillance","subtitle":"a method comparison and application in clinical practice"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"8 S.","noteIll":"Diagramme"}],"id":{"doi":["10.1158/1940-6207.CAPR-24-0328","10.25673/118313"],"eki":["191390508X"]},"origin":[{"dateIssuedDisp":"November 22, 2024","dateIssuedKey":"2024"}],"name":{"displayForm":["$hSilke Zachariae, Anne S. Quante, Marion Kiechle, Kerstin Rhiem, Tanja N. Fehm, Jörg-Gunther Schröder, Judit Horvath, Elena Leinert, Nicola Dikow, Joelle Ronez, Mirjam Schönfeld, Marion T. van Mackelenbergh, Ulrich A. Schatz, Cornelia Meisel, Bahriye Aktas, Dennis Witt, Yasmin Mehraein, Bernhard H.F. Weber, Christine Solbach, Dorothee Speiser, Juliane Hoyer, Gesine Faigle-Krehl, Christiane D. Much, Alma-Verena Müller-Rausch, Pablo Villavicencio-Lorini, Maggie Banys-Paluchowski, Daniel Pieh, Rita K. Schmutzler, Christine Fischer and Christoph Engel"]},"recId":"191390508X","note":["Gesehen am 23.10.2025"],"relHost":[{"language":["eng"],"pubHistory":["1.2008 -"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 09.06.2023","Fortsetzung der Druck-Ausgabe"],"title":[{"title_sort":"Cancer Prevention Research","title":"Cancer Prevention Research"}],"disp":"Calculating future 10-year breast cancer risks in risk-adapted surveillance a method comparison and application in clinical practiceCancer Prevention Research","name":{"displayForm":["American Association for Cancer Research"]},"recId":"564751022","part":{"text":"18(2025), 2, Seite 85-92","extent":"8","pages":"85-92","volume":"18","issue":"2","year":"2025"},"id":{"eki":["564751022"],"zdb":["2422346-3"],"issn":["1940-6215"]},"origin":[{"dateIssuedDisp":"2008-","publisher":"AACR","dateIssuedKey":"2008","publisherPlace":"Philadelphia, Pa."}]}]} | ||
| SRT | |a ZACHARIAESCALCULATIN2220 | ||