Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC): an open label, randomized, stratified, phase II trial
Introduction - Sacrococcygeal chordomas have high recurrence rates and are challenging to treat. - Methods - In this phase II prospective, randomized, stratified trial, the safety and feasibility of hypofractionated ion radiation therapy were investigated. The primary focus was monitored through the...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2024
|
| In: |
Radiotherapy and oncology
Year: 2024, Jahrgang: 198, Pages: 1-7 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2024.110418 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.radonc.2024.110418 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814024006881 
|
| Verfasserangaben: | Katharina Seidensaal, Andreas Froehlke, Adriane Lentz-Hommertgen, Burkhard Lehner, Andreas Geisbuesch, Jan Meis, Jakob Liermann, Andreas Kudak, Katharina Stein, Matthias Uhl, Thomas Tessonnier, Andrea Mairani, Juergen Debus, Klaus Herfarth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1914147073 | ||
| 003 | DE-627 | ||
| 005 | 20250716221631.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250110s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.radonc.2024.110418 |2 doi | |
| 035 | |a (DE-627)1914147073 | ||
| 035 | |a (DE-599)KXP1914147073 | ||
| 035 | |a (OCoLC)1528015962 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Seidensaal, Katharina |d 1987- |e VerfasserIn |0 (DE-588)1084643685 |0 (DE-627)848624483 |0 (DE-576)456394869 |4 aut | |
| 245 | 1 | 0 | |a Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC) |b an open label, randomized, stratified, phase II trial |c Katharina Seidensaal, Andreas Froehlke, Adriane Lentz-Hommertgen, Burkhard Lehner, Andreas Geisbuesch, Jan Meis, Jakob Liermann, Andreas Kudak, Katharina Stein, Matthias Uhl, Thomas Tessonnier, Andrea Mairani, Juergen Debus, Klaus Herfarth |
| 264 | 1 | |c September 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 27. Juni 2024, Artikelversion: 3. Juli 2024 | ||
| 500 | |a Gesehen am 10.01.2025 | ||
| 520 | |a Introduction - Sacrococcygeal chordomas have high recurrence rates and are challenging to treat. - Methods - In this phase II prospective, randomized, stratified trial, the safety and feasibility of hypofractionated ion radiation therapy were investigated. The primary focus was monitored through the incidence of Grade 3-5 NCI-CTC-AE toxicity. Secondary endpoints included local progression-free (LPFS) and overall survival (OS). - Results - The study enrolled 82 patients with primary (87 %) and recurrent (13 %) inoperable or incompletely resected sacral chordomas from January 2013 to July 2022, divided equally into proton therapy (Arm A) and carbon ion beam therapy (Arm B) groups, each receiving a total dose of 64 Gy (RBE) in 16 fractions, 5-6 fractions per week. Overall 74 % of patients received no previous surgery and 66 % of tumors were confirmed by a brachyury staining. The mean and median Gross Tumor Volume at the time of treatment (GTV) was 407 ml and 185 ml, respectively. The median follow-up of the surviving patients was 44.7 months, and the 2-year and 4-year OS rates were 96 % and 81 %, respectively. Factors such as smaller GTV and younger age trended towards better OS. The LPFS after 2-year and 4-year was 84 % and 70 %, respectively. Male gender emerged as a significant predictor of LPFS. There was no significant difference between the treatment groups. We observed five grade 4 wound healing disorders (6 %). - Conclusion - The initial response rates were promising; however local control was not sustained. More comparative research on fractionation schemes is essential to refine treatment approaches for inoperable sacral chordoma. | ||
| 650 | 4 | |a Carbon ions | |
| 650 | 4 | |a Phase II trial | |
| 650 | 4 | |a Protons | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a Sacrococcygeal chordoma | |
| 700 | 1 | |a Froehlke, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hommertgen, Adriane |e VerfasserIn |0 (DE-588)1163409006 |0 (DE-627)1027777600 |0 (DE-576)507971353 |4 aut | |
| 700 | 1 | |a Lehner, Burkhard |e VerfasserIn |0 (DE-588)1063147808 |0 (DE-627)810647311 |0 (DE-576)420525297 |4 aut | |
| 700 | 1 | |a Geisbüsch, Andreas |d 1984- |e VerfasserIn |0 (DE-588)1026036178 |0 (DE-627)725953306 |0 (DE-576)37102899X |4 aut | |
| 700 | 1 | |a Meis, Jan |d 1992- |e VerfasserIn |0 (DE-588)1261856112 |0 (DE-627)180919900X |4 aut | |
| 700 | 1 | |a Liermann, Jakob |d 1989- |e VerfasserIn |0 (DE-588)1147779287 |0 (DE-627)1007181842 |0 (DE-576)496034170 |4 aut | |
| 700 | 1 | |a Kudak, Andreas |e VerfasserIn |0 (DE-588)1223468003 |0 (DE-627)174282773X |4 aut | |
| 700 | 1 | |a Stein, Katharina |e VerfasserIn |0 (DE-588)1353060179 |0 (DE-627)1914147251 |4 aut | |
| 700 | 1 | |a Uhl, Matthias |d 1979- |e VerfasserIn |0 (DE-588)133372561 |0 (DE-627)544031091 |0 (DE-576)299803147 |4 aut | |
| 700 | 1 | |a Tessonnier, Thomas |e VerfasserIn |0 (DE-588)1075079195 |0 (DE-627)83292685X |0 (DE-576)443252270 |4 aut | |
| 700 | 1 | |a Mairani, Andrea |e VerfasserIn |0 (DE-588)1116742179 |0 (DE-627)870669281 |0 (DE-576)478592493 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Herfarth, Klaus |e VerfasserIn |0 (DE-588)1032757582 |0 (DE-627)739273116 |0 (DE-576)171352289 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiotherapy and oncology |d Amsterdam [u.a.] : Elsevier Science, 1983 |g 198(2024) vom: Sept., Artikel-ID 110418, Seite 1-7 |h Online-Ressource |w (DE-627)306710110 |w (DE-600)1500707-8 |w (DE-576)082435731 |x 1879-0887 |7 nnas |a Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC) an open label, randomized, stratified, phase II trial |
| 773 | 1 | 8 | |g volume:198 |g year:2024 |g month:09 |g elocationid:110418 |g pages:1-7 |g extent:7 |a Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC) an open label, randomized, stratified, phase II trial |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.radonc.2024.110418 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0167814024006881 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250110 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1032757582 |a Herfarth, Klaus |m 1032757582:Herfarth, Klaus |d 910000 |d 911400 |d 50000 |e 910000PH1032757582 |e 911400PH1032757582 |e 50000PH1032757582 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 14 |y j | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 13 | ||
| 998 | |g 1116742179 |a Mairani, Andrea |m 1116742179:Mairani, Andrea |d 50000 |e 50000PM1116742179 |k 0/50000/ |p 12 | ||
| 998 | |g 133372561 |a Uhl, Matthias |m 133372561:Uhl, Matthias |d 50000 |e 50000PU133372561 |k 0/50000/ |p 10 | ||
| 998 | |g 1353060179 |a Stein, Katharina |m 1353060179:Stein, Katharina |d 910000 |d 911400 |e 910000PS1353060179 |e 911400PS1353060179 |k 0/910000/ |k 1/910000/911400/ |p 9 | ||
| 998 | |g 1223468003 |a Kudak, Andreas |m 1223468003:Kudak, Andreas |d 910000 |d 911400 |e 910000PK1223468003 |e 911400PK1223468003 |k 0/910000/ |k 1/910000/911400/ |p 8 | ||
| 998 | |g 1147779287 |a Liermann, Jakob |m 1147779287:Liermann, Jakob |d 910000 |d 911400 |d 50000 |e 910000PL1147779287 |e 911400PL1147779287 |e 50000PL1147779287 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 7 | ||
| 998 | |g 1261856112 |a Meis, Jan |m 1261856112:Meis, Jan |d 910000 |d 911800 |e 910000PM1261856112 |e 911800PM1261856112 |k 0/910000/ |k 1/910000/911800/ |p 6 | ||
| 998 | |g 1026036178 |a Geisbüsch, Andreas |m 1026036178:Geisbüsch, Andreas |d 910000 |d 911400 |e 910000PG1026036178 |e 911400PG1026036178 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 1063147808 |a Lehner, Burkhard |m 1063147808:Lehner, Burkhard |d 910000 |d 911400 |e 910000PL1063147808 |e 911400PL1063147808 |k 0/910000/ |k 1/910000/911400/ |p 4 | ||
| 998 | |g 1163409006 |a Hommertgen, Adriane |m 1163409006:Hommertgen, Adriane |d 910000 |d 911400 |e 910000PH1163409006 |e 911400PH1163409006 |k 0/910000/ |k 1/910000/911400/ |p 3 | ||
| 998 | |g 1084643685 |a Seidensaal, Katharina |m 1084643685:Seidensaal, Katharina |d 910000 |d 911400 |e 910000PS1084643685 |e 911400PS1084643685 |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1914147073 |e 464949107X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1914147073"],"doi":["10.1016/j.radonc.2024.110418"]},"name":{"displayForm":["Katharina Seidensaal, Andreas Froehlke, Adriane Lentz-Hommertgen, Burkhard Lehner, Andreas Geisbuesch, Jan Meis, Jakob Liermann, Andreas Kudak, Katharina Stein, Matthias Uhl, Thomas Tessonnier, Andrea Mairani, Juergen Debus, Klaus Herfarth"]},"physDesc":[{"extent":"7 S.","noteIll":"Illustrationen"}],"recId":"1914147073","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online verfügbar: 27. Juni 2024, Artikelversion: 3. Juli 2024","Gesehen am 10.01.2025"],"title":[{"title_sort":"Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC)","title":"Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC)","subtitle":"an open label, randomized, stratified, phase II trial"}],"origin":[{"dateIssuedDisp":"September 2024","dateIssuedKey":"2024"}],"relHost":[{"disp":"Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC) an open label, randomized, stratified, phase II trialRadiotherapy and oncology","physDesc":[{"extent":"Online-Ressource"}],"recId":"306710110","note":["Gesehen am 30.05.15","Ungezählte Beil.: Supplement"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Radiotherapy and oncology","title_sort":"Radiotherapy and oncology","subtitle":"journal of the European Society for Therapeutic Radiology and Oncology"}],"origin":[{"publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1983","dateIssuedDisp":"1983-"}],"part":{"text":"198(2024) vom: Sept., Artikel-ID 110418, Seite 1-7","volume":"198","extent":"7","pages":"1-7","year":"2024"},"id":{"zdb":["1500707-8"],"eki":["306710110"],"issn":["1879-0887"]},"titleAlt":[{"title":"The green journal"}],"pubHistory":["1.1983 -"]}],"person":[{"role":"aut","given":"Katharina","family":"Seidensaal","display":"Seidensaal, Katharina"},{"display":"Froehlke, Andreas","given":"Andreas","role":"aut","family":"Froehlke"},{"display":"Hommertgen, Adriane","given":"Adriane","role":"aut","family":"Hommertgen"},{"display":"Lehner, Burkhard","role":"aut","given":"Burkhard","family":"Lehner"},{"display":"Geisbüsch, Andreas","family":"Geisbüsch","given":"Andreas","role":"aut"},{"display":"Meis, Jan","given":"Jan","role":"aut","family":"Meis"},{"display":"Liermann, Jakob","given":"Jakob","role":"aut","family":"Liermann"},{"given":"Andreas","role":"aut","family":"Kudak","display":"Kudak, Andreas"},{"display":"Stein, Katharina","given":"Katharina","role":"aut","family":"Stein"},{"family":"Uhl","given":"Matthias","role":"aut","display":"Uhl, Matthias"},{"display":"Tessonnier, Thomas","family":"Tessonnier","role":"aut","given":"Thomas"},{"display":"Mairani, Andrea","family":"Mairani","role":"aut","given":"Andrea"},{"family":"Debus","given":"Jürgen","role":"aut","display":"Debus, Jürgen"},{"family":"Herfarth","given":"Klaus","role":"aut","display":"Herfarth, Klaus"}]} | ||
| SRT | |a SEIDENSAALHYPOFRACTI2024 | ||