Buchumschlag

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy

The long-term consequences of cancer and its therapy on the patients’ immune system years after cancer-free survival remain poorly understood. Here, we present an in-depth characterization of the bone marrow immune ecosystem of multiple myeloma long-term survivors, from initial diagnosis up to 17 ye...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lutz, Raphael (VerfasserIn) , Grünschläger, Florian (VerfasserIn) , Simon, Malte (VerfasserIn) , Bauer, Marcus (VerfasserIn) , Awwad, Mohamed (VerfasserIn) , Yousefian, Schayan (VerfasserIn) , Beumer, Niklas (VerfasserIn) , Jopp-Saile, Lea (VerfasserIn) , Sedlmeier, Anastasia (VerfasserIn) , Solé-Boldo, Llorenç (VerfasserIn) , Avanesyan, Bogdan (VerfasserIn) , Vonficht, Dominik (VerfasserIn) , Stelmach, Patrick (VerfasserIn) , Steinbuss, Georg (VerfasserIn) , Boch, Tobias (VerfasserIn) , Steiger, Simon (VerfasserIn) , Bärtsch, Marc-Andrea (VerfasserIn) , Prokoph, Nina (VerfasserIn) , Rippe, Karsten (VerfasserIn) , Wickenhauser, Claudia (VerfasserIn) , Durie, Brian G. M. (VerfasserIn) , Trumpp, Andreas (VerfasserIn) , Müller-Tidow, Carsten (VerfasserIn) , Hübschmann, Daniel (VerfasserIn) , Weinhold, Niels (VerfasserIn) , Raab, Marc-Steffen (VerfasserIn) , Brors, Benedikt (VerfasserIn) , Goldschmidt, Hartmut (VerfasserIn) , Imbusch, Charles (VerfasserIn) , Hundemer, Michael (VerfasserIn) , Haas, Simon (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 November 2024
In: Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-18
ISSN:2041-1723
DOI:10.1038/s41467-024-54543-0
Online-Zugang:Resolving-System, kostenfrei: https://doi.org/10.1038/s41467-024-54543-0
Resolving-System, kostenfrei: https://doi.org/10.25673/117853
Volltext
Verfasserangaben:Raphael Lutz, Florian Grünschläger, Malte Simon, Mohamed H. S. Awwad, Marcus Bauer, Schayan Yousefian, Niklas Beumer, Lea Jopp-Saile, Anastasia Sedlmeier, Llorenç Solé-Boldo, Bogdan Avanesyan, Dominik Vonficht, Patrick Stelmach, Georg Steinbuss, Tobias Boch, Simon Steiger, Marc-Andrea Baertsch, Nina Prokoph, Karsten Rippe, Brian G. M. Durie, Claudia Wickenhauser, Andreas Trumpp, Carsten Müller-Tidow, Daniel Hübschmann, Niels Weinhold, Marc S. Raab, Benedikt Brors, Hartmut Goldschmidt, Charles D. Imbusch, Michael Hundemer & Simon Haas
Beschreibung
Zusammenfassung:The long-term consequences of cancer and its therapy on the patients’ immune system years after cancer-free survival remain poorly understood. Here, we present an in-depth characterization of the bone marrow immune ecosystem of multiple myeloma long-term survivors, from initial diagnosis up to 17 years following a single therapy line and cancer-free survival. Using comparative single-cell analyses combined with molecular, genomic, and functional approaches, we demonstrate that multiple myeloma long-term survivors exhibit pronounced alterations in their bone marrow microenvironment associated with impaired immunity. These immunological alterations were frequently linked to an inflammatory immune circuit fueled by the long-term persistence or resurgence of residual myeloma cells. Notably, even in the complete absence of any detectable residual disease for decades, sustained changes in the immune system were observed, suggesting an irreversible ‘immunological scarring’ caused by the initial exposure to the cancer and therapy. Collectively, our study provides key insights into the molecular and cellular bone marrow ecosystem of long-term survivors of multiple myeloma, revealing both reversible and irreversible alterations in the immune compartment.
Beschreibung:Gesehen am 20.05.2025
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-024-54543-0

Ähnliche Einträge