Asymmetry, cytoarchitectonic morphology and genetics associated with Broca’s area in schizophrenia
A common hypothesis on the etiopathology of schizophrenia is that the failure of segregation of right from left hemisphere functions is a core deficit in psychosis. It has even been proposed that schizophrenia symptoms in general may reflect a hemispheric ‘dominance failure’ for language and that th...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 January 2024
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| In: |
Nature Mental Health
Year: 2024, Jahrgang: 2, Heft: 3, Pages: 310-319 |
| ISSN: | 2731-6076 |
| DOI: | 10.1038/s44220-023-00200-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s44220-023-00200-2 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s44220-023-00200-2 
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| Verfasserangaben: | Saskia Zimmermann, Katrin Sakreida, Sebastian Bludau, Julia A. Camilleri, Felix Hoffstaedter, Dominique I. Pelzer, André Aleman, Torsten Brückner, Birgit Derntl, Elmar Frank, Thomas Frodl, Paola Fuentes-Claramonte, María Ángeles García-León, Oliver Gruber, Göran Hajak, Stefan Heim, Renaud Jardri, Lydia Kogler, Peter M. Kreuzer, Daniela Mirlach, Michael Landgrebe, Berthold Langguth, Edith Pomarol-Clotet, Julia Prasser, Martin Schecklmann, Kang Sim, Joan Soler-Vidal, Iris E. Sommer, Juan H. Zhou, Thomas W. Mühleisen, Simon B. Eickhoff & Timm B. Poeppl |
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| 245 | 1 | 0 | |a Asymmetry, cytoarchitectonic morphology and genetics associated with Broca’s area in schizophrenia |c Saskia Zimmermann, Katrin Sakreida, Sebastian Bludau, Julia A. Camilleri, Felix Hoffstaedter, Dominique I. Pelzer, André Aleman, Torsten Brückner, Birgit Derntl, Elmar Frank, Thomas Frodl, Paola Fuentes-Claramonte, María Ángeles García-León, Oliver Gruber, Göran Hajak, Stefan Heim, Renaud Jardri, Lydia Kogler, Peter M. Kreuzer, Daniela Mirlach, Michael Landgrebe, Berthold Langguth, Edith Pomarol-Clotet, Julia Prasser, Martin Schecklmann, Kang Sim, Joan Soler-Vidal, Iris E. Sommer, Juan H. Zhou, Thomas W. Mühleisen, Simon B. Eickhoff & Timm B. Poeppl |
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| 520 | |a A common hypothesis on the etiopathology of schizophrenia is that the failure of segregation of right from left hemisphere functions is a core deficit in psychosis. It has even been proposed that schizophrenia symptoms in general may reflect a hemispheric ‘dominance failure’ for language and that the corresponding predisposition is genetic. Here, we show that reduced asymmetries of cytoarchitectonic Broca’s subareas link to the degree of specific psychopathology and that specific gray matter reductions of subareas are related to a cognitive and a negative subtype of schizophrenia. Gene expression analyses indicate an upregulation of the MET gene in these particular areas, which has been implicated in neurodevelopment as well as neurocognition and influences the risk for schizophrenia. Our integrative findings suggest that variations of MET are associated with distinct structural alterations at the subregional level in key language regions, which may contribute to development of specific psychopathology in schizophrenia. | ||
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