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G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells

Neurofibromatosis Type II (NFII) is a genetic condition caused by loss of the NF2 gene, resulting in activation of the YAP/TAZ pathway and recurrent Schwann cell tumors, as well as meningiomas and ependymomas. Unfortunately, few pharmacological options are available for NFII. Here, we undertake a ge...

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Hauptverfasser: Kyrkou, Athena (VerfasserIn) , Valla, Robert (VerfasserIn) , Zhang, Yao (VerfasserIn) , Ambrosi, Giulia (VerfasserIn) , Laier, Stephanie (VerfasserIn) , Müller-Decker, Karin (VerfasserIn) , Boutros, Michael (VerfasserIn) , Teleman, Aurelio A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 June 2024
In: Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-15
ISSN:2041-1723
DOI:10.1038/s41467-024-49298-7
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-49298-7
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Verfasserangaben:Athena Kyrkou, Robert Valla, Yao Zhang, Giulia Ambrosi, Stephanie Laier, Karin Müller-Decker, Michael Boutros & Aurelio A. Teleman

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