Neural deception: breast cancer co-opts neuronal mechanisms to evade the immune system
Cellular mechanisms mediating immunotherapy resistances are incompletely understood. In this issue, Li et al. reveal how breast cancer hijacks neuronal mechanisms of neuroprotection to shield itself from the immune system. Secretion of N-acetylaspartate impairs immune synapse formation in both neuro...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 May 2024
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| In: |
Cancer cell
Year: 2024, Volume: 42, Issue: 6, Pages: 936-938 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2024.05.007 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2024.05.007 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610824001703 
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| Author Notes: | Nikolas Layer, Lukas Bunse, and Varun Venkataramani |
| Summary: | Cellular mechanisms mediating immunotherapy resistances are incompletely understood. In this issue, Li et al. reveal how breast cancer hijacks neuronal mechanisms of neuroprotection to shield itself from the immune system. Secretion of N-acetylaspartate impairs immune synapse formation in both neuroinflammation and breast cancer models, paving the way for novel therapeutic approaches. |
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| Item Description: | Online verfügbar: 30. Mai 2024, Artikelversion: 10. Juni 2024 Gesehen am 20.01.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2024.05.007 |