Prevalence and associations of dome-shaped maculas: the Beijing Eye Study
Purpose To explore the prevalence and associated factors of a dome-shaped macula (DSM) in a general population. Methods Out of the population-based Beijing Eye Study cohort (n = 3468 participants), the investigation included all eyes with an axial length of ≥25 mm, and a randomized sample of eyes wi...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2024
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| In: |
Acta ophthalmologica
Year: 2024, Jahrgang: 103, Heft: 2, Pages: 177-185 |
| ISSN: | 1755-3768 |
| DOI: | 10.1111/aos.16764 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/aos.16764 Verlag, lizenzpflichtig, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/aos.16764 
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| Verfasserangaben: | Jost B. Jonas, Songhomitra Panda-Jonas, Wen-Bin Wei, Jie Xu, Ya Xing Wang |
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| 245 | 1 | 0 | |a Prevalence and associations of dome-shaped maculas |b the Beijing Eye Study |c Jost B. Jonas, Songhomitra Panda-Jonas, Wen-Bin Wei, Jie Xu, Ya Xing Wang |
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| 520 | |a Purpose To explore the prevalence and associated factors of a dome-shaped macula (DSM) in a general population. Methods Out of the population-based Beijing Eye Study cohort (n = 3468 participants), the investigation included all eyes with an axial length of ≥25 mm, and a randomized sample of eyes with an axial length of <25 mm. Using optical coherence tomographic (OCT) images, we examined presence and height of DSMs, defined as an inward convexity of the foveal retinal pigment epithelium (RPE)/Bruch's membrane (BM) line, detectable in at least two OCT scans perpendicularly orientated to each other. Results The study cohort consisted of 366 eyes (314 individuals) with a mean age of 63.7 ± 9.7 years and a mean axial length of 24.8 ± 2.1 mm (median: 25.1 mm; range: 18.96-30.88 mm). Prevalence of DSMs (found in 6/366 eyes; 1.9%; 95%CI: 1.0, 3.0) increased from 0/125 (0%) in non-myopic eyes to 1/152 (0.7%; 95%CI: 0.0, 2.0) in moderately myopic eyes, and to 6/83 (7.2%; 95%CI: 1.7, 12.7) in the highly myopic group. In multivariable analysis, higher DSM prevalence corelated with longer axial length (OR: 2.05; 95%CI: 1.36, 3.08; p < 0.001) and higher stage of myopic macular degeneration (OR: 1.08; 95%CI: 1.01, 1.16; p = 0.03). The mean maximal DSM height was 139 ± 107 μm (median: 100 μm; range: 25-350 μm). It was associated with higher stage of myopic macular degeneration (beta: 0.24; p < 0.001) and higher prevalence of macular BM defects (beta: 0.17; p < 0.001). None of the DSMs showed a serous retinal detachment or relative choroidal thickening. Conclusions Higher DSM prevalence correlated non-linearly with longer axial length, with DSM height increasing with the presence of a BM defect. DSMs may be associated with an axial elongation-related BM overproduction in the fundus midperiphery in all meridians. | ||
| 650 | 4 | |a axial elongation | |
| 650 | 4 | |a Beijing Eye Study | |
| 650 | 4 | |a dome-shaped macula | |
| 650 | 4 | |a high myopia | |
| 650 | 4 | |a macular ridge | |
| 650 | 4 | |a myopic macular degeneration | |
| 650 | 4 | |a parapapillary scleral ridge | |
| 650 | 4 | |a posterior staphyloma | |
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| 700 | 1 | |a Wang, Ya Xing |e VerfasserIn |4 aut | |
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