Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a complex disease with advanced presentation that significantly affects survival rates. Therefore, novel therapeutic strategies are needed. In this study, we investigate the tumor microenvironment (TME) in HCC by analyzing 13 HCC samples at single cell level. We ide...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 September 2024
|
| In: |
Apoptosis
Year: 2024, Pages: 1-14 |
| ISSN: | 1573-675X |
| DOI: | 10.1007/s10495-024-02019-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10495-024-02019-3 Verlag, kostenfrei, Volltext: http://link.springer.com/article/10.1007/s10495-024-02019-3 
|
| Verfasserangaben: | Jiahua Liang, Mingjian Ma, Wei Feng, Qiongcong Xu, Dong Chen, Jiaming Lai, Jiancong Chen |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1915214742 | ||
| 003 | DE-627 | ||
| 005 | 20250716223443.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250121s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10495-024-02019-3 |2 doi | |
| 035 | |a (DE-627)1915214742 | ||
| 035 | |a (DE-599)KXP1915214742 | ||
| 035 | |a (OCoLC)1528016802 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Liang, Jiahua |d 1996- |e VerfasserIn |0 (DE-588)1353937348 |0 (DE-627)1915214408 |4 aut | |
| 245 | 1 | 0 | |a Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma |c Jiahua Liang, Mingjian Ma, Wei Feng, Qiongcong Xu, Dong Chen, Jiaming Lai, Jiancong Chen |
| 264 | 1 | |c 26 September 2024 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.01.2025 | ||
| 520 | |a Hepatocellular carcinoma (HCC) is a complex disease with advanced presentation that significantly affects survival rates. Therefore, novel therapeutic strategies are needed. In this study, we investigate the tumor microenvironment (TME) in HCC by analyzing 13 HCC samples at single cell level. We identified key cell populations, including CD8 + T cells, Tregs, M1/M2 macrophages, and CD4 + memory T cells, and explored their roles and interactions. Our research revealed an early enrichment of CD8 + T cells, which could potentially lead to their exhaustion and facilitate tumor progression. We also investigated the impact of percutaneous radiofrequency ablation (RFA) on the immune microenvironment. Using a dual tumor mouse model, we demonstrated that RFA induces necrosis, enhancing antigen presentation and altering immune responses. Our results indicate that RFA increases PD-L1 expression in residual liver tissue, suggesting potential immune escape mechanisms. Furthermore, the combination of RFA and anti-PD-L1 therapy in the mouse model resulted in significant improvements in immune modulation. This included increased CD8 + T cell efficacy and decreased Treg infiltration. This combination shows promise as an approach to counteract HCC progression by altering the immune landscape. This study highlights the critical interaction within the TME of HCC and suggests the possibility of improving patient outcomes by targeting immune evasion mechanisms through combined therapeutic strategies. | ||
| 700 | 1 | |a Ma, Mingjian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Feng, Wei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Xu, Qiongcong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Dong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lai, Jiaming |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Jiancong |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Apoptosis |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996 |g (2024), Seite 1-14 |h Online-Ressource |w (DE-627)306311577 |w (DE-600)1495863-6 |w (DE-576)121190617 |x 1573-675X |7 nnas |a Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma |
| 773 | 1 | 8 | |g year:2024 |g pages:1-14 |g extent:14 |a Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10495-024-02019-3 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://link.springer.com/article/10.1007/s10495-024-02019-3 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250121 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1353937348 |a Liang, Jiahua |m 1353937348:Liang, Jiahua |d 60000 |e 60000PL1353937348 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1915214742 |e 4654698523 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 21.01.2025"],"recId":"1915214742","language":["eng"],"person":[{"role":"aut","display":"Liang, Jiahua","roleDisplay":"VerfasserIn","given":"Jiahua","family":"Liang"},{"family":"Ma","given":"Mingjian","roleDisplay":"VerfasserIn","display":"Ma, Mingjian","role":"aut"},{"given":"Wei","family":"Feng","role":"aut","display":"Feng, Wei","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Xu, Qiongcong","role":"aut","family":"Xu","given":"Qiongcong"},{"family":"Chen","given":"Dong","roleDisplay":"VerfasserIn","display":"Chen, Dong","role":"aut"},{"family":"Lai","given":"Jiaming","roleDisplay":"VerfasserIn","display":"Lai, Jiaming","role":"aut"},{"given":"Jiancong","family":"Chen","role":"aut","display":"Chen, Jiancong","roleDisplay":"VerfasserIn"}],"title":[{"title":"Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma","title_sort":"Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma"}],"physDesc":[{"extent":"14 S."}],"relHost":[{"id":{"zdb":["1495863-6"],"eki":["306311577"],"issn":["1573-675X"]},"origin":[{"publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","dateIssuedDisp":"1996-","publisher":"Springer Science + Business Media B.V ; Kluwer Academic Publ.","dateIssuedKey":"1996"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Apoptosis","subtitle":"an international journal on programmed cell death","title_sort":"Apoptosis"}],"recId":"306311577","language":["eng"],"note":["Gesehen am 07.10.05"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinomaApoptosis","part":{"extent":"14","text":"(2024), Seite 1-14","pages":"1-14","year":"2024"},"pubHistory":["1.1996 -"]}],"name":{"displayForm":["Jiahua Liang, Mingjian Ma, Wei Feng, Qiongcong Xu, Dong Chen, Jiaming Lai, Jiancong Chen"]},"origin":[{"dateIssuedDisp":"26 September 2024","dateIssuedKey":"2024"}],"id":{"doi":["10.1007/s10495-024-02019-3"],"eki":["1915214742"]}} | ||
| SRT | |a LIANGJIAHUANTIPDL1BL2620 | ||