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3D human tissue models and microphysiological systems for HIV and related comorbidities

Three-dimensional (3D) human tissue models/microphysiological systems (e.g., organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and have potential to address critical questions, including characterization of viral reservoirs, insufficient innate and adaptive immune...

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Hauptverfasser: Yin, Dwight E. (VerfasserIn) , Palin, Amy C. (VerfasserIn) , Lombo, Tania B. (VerfasserIn) , Mahon, Robert N. (VerfasserIn) , Poon, Betty (VerfasserIn) , Wu, Da-Yu (VerfasserIn) , Atala, Anthony (VerfasserIn) , Brooks, Kristina M. (VerfasserIn) , Chen, Shuibing (VerfasserIn) , Coyne, Carolyn B. (VerfasserIn) , D’Souza, M. Patricia (VerfasserIn) , Fackler, Oliver Till (VerfasserIn) , Furler O’Brien, Robert L. (VerfasserIn) , Garcia-de-Alba, Carolina (VerfasserIn) , Jean-Philippe, Patrick (VerfasserIn) , Karn, Jonathan (VerfasserIn) , Majji, Sai (VerfasserIn) , Muotri, Alysson R. (VerfasserIn) , Ozulumba, Tochukwu (VerfasserIn) , Sakatis, Melanie Z. (VerfasserIn) , Schlesinger, Larry S. (VerfasserIn) , Singh, Anjali (VerfasserIn) , Spiegel, Hans M. L. (VerfasserIn) , Struble, Evi (VerfasserIn) , Sung, Kyung (VerfasserIn) , Tagle, Danilo A. (VerfasserIn) , Thacker, Vivek V. (VerfasserIn) , Tidball, Andrew M. (VerfasserIn) , Varthakavi, Vasundhara (VerfasserIn) , Vunjak-Novakovic, Gordana (VerfasserIn) , Wagar, Lisa E. (VerfasserIn) , Yeung, Catherine K. (VerfasserIn) , Ndhlovu, Lishomwa C. (VerfasserIn) , Ott, Melanie (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 2024
In: Trends in biotechnology
Year: 2024, Jahrgang: 42, Heft: 5, Pages: 526-543
ISSN:1879-3096
DOI:10.1016/j.tibtech.2023.10.008
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibtech.2023.10.008
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167779923002998
Volltext
Verfasserangaben:Dwight E. Yin, Amy C. Palin, Tania B. Lombo, Robert N. Mahon, Betty Poon, Da-Yu Wu, Anthony Atala, Kristina M. Brooks, Shuibing Chen, Carolyn B. Coyne, M. Patricia D’Souza, Oliver T. Fackler, Robert L. Furler O’Brien, Carolina Garcia-de-Alba, Patrick Jean-Philippe, Jonathan Karn, Sai Majji, Alysson R. Muotri, Tochukwu Ozulumba, Melanie Z. Sakatis, Larry S. Schlesinger, Anjali Singh, Hans M.L. Spiegel, Evi Struble, Kyung Sung, Danilo A. Tagle, Vivek V. Thacker, Andrew M. Tidball, Vasundhara Varthakavi, Gordana Vunjak-Novakovic, Lisa E. Wagar, Catherine K. Yeung, Lishomwa C. Ndhlovu, Melanie Ott
Beschreibung
Zusammenfassung:Three-dimensional (3D) human tissue models/microphysiological systems (e.g., organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and have potential to address critical questions, including characterization of viral reservoirs, insufficient innate and adaptive immune responses, biomarker discovery and evaluation, medical complexity with comorbidities (e.g., tuberculosis and SARS-CoV-2), and protection and transmission during pregnancy and birth. Composed of multiple primary or stem cell-derived cell types organized in a dedicated 3D space, these systems hold unique promise for better reproducing human physiology, advancing therapeutic development, and bridging the human-animal model translational gap. Here, we discuss the promises and achievements with 3D human tissue models in HIV and comorbidity research, along with remaining barriers with respect to cell biology, virology, immunology, and regulatory issues.
Beschreibung:Online verfügbar 8 December 2023, Version des Artikels 1 May 2024
Gesehen am 24.01.2025
Beschreibung:Online Resource
ISSN:1879-3096
DOI:10.1016/j.tibtech.2023.10.008

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