Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy?: Medical imaging : radiation oncology
Introduction In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 2024
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| In: |
Journal of medical imaging and radiation oncology
Year: 2024, Volume: 68, Issue: 7, Pages: 862-869 |
| ISSN: | 1754-9485 |
| DOI: | 10.1111/1754-9485.13783 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/1754-9485.13783 Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/1754-9485.13783 
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| Author Notes: | Hannah L Steinberg-Vorhoff, Saskia C Ting, Sebastian Zensen, Johannes M Ludwig, Yan Li, Heike Richly, Johannes Grüneisen, Jens T Siveke, Jens M Theysohn and Benedikt M Schaarschmidt |
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| 245 | 1 | 0 | |a Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy? |b Medical imaging : radiation oncology |c Hannah L Steinberg-Vorhoff, Saskia C Ting, Sebastian Zensen, Johannes M Ludwig, Yan Li, Heike Richly, Johannes Grüneisen, Jens T Siveke, Jens M Theysohn and Benedikt M Schaarschmidt |
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| 520 | |a Introduction In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in UM patients undergoing HAIC. Methods A retrospective analysis with 60 UM patients (29 females, mean age: 61.6 ± 12.1 years) with hepatic metastases was performed. Histomorphological patterns in metastases were analysed and classified as either predominant spindle cell or epithelioid pattern. mOS between both patient groups was analysed using Kaplan-Meier curves and the log-rank test. Results In 73.3% (44/60) of the metastases, a predominant epithelioid pattern, in 21.7% (13/60) a predominant spindle cell pattern, and in 5% (3/60) other patterns were found. No significant differences between patients with an epithelioid (mOS: 14.2 months, 95% CI: 8.8-19.6) and a spindle cell pattern (mOS: 14.4 months, 95% CI: 4.3-24.5) were detected by the log-rank test, χ2(2) = 0.22, P = 0.881. Conclusion Histomorphological patterns of UM metastases do not seem to be a predictor for mOS in UM patients undergoing HAIC. | ||
| 650 | 4 | |a HAIC | |
| 650 | 4 | |a hepatic artery infusion therapy | |
| 650 | 4 | |a histomorphological pattern | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Ting, Saskia C |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zensen, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ludwig, Johannes Maximilian |d 1984- |e VerfasserIn |0 (DE-588)1072015560 |0 (DE-627)826782949 |0 (DE-576)433484144 |4 aut | |
| 700 | 1 | |a Li, Yan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Richly, Heike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grüneisen, Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siveke, Jens T |e VerfasserIn |4 aut | |
| 700 | 1 | |a Theysohn, Jens M |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schaarschmidt, Benedikt M |e VerfasserIn |4 aut | |
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