European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia: Final analysis and novel prognostic factors for treatment-free remission
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 1, 2024
|
| In: |
Journal of clinical oncology
Year: 2024, Jahrgang: 42, Heft: 16, Pages: 1875-1880 |
| ISSN: | 1527-7755 |
| DOI: | 10.1200/JCO.23.01647 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1200/JCO.23.01647 Verlag, kostenfrei, Volltext: https://ascopubs.org/doi/10.1200/JCO.23.01647 
|
| Verfasserangaben: | Francois-Xavier Mahon, MD, PhD; Markus Pfirrmann, PhD; Stéphanie Dulucq, PhD; Andreas Hochhaus, MD, PhD; Panayiotis Panayiotidis, MD, PhD; Antonio Almeida, MD, PhD; Jiri Mayer, MD, PhD; Henrik Hjorth-Hansen, MD, PhD; Jeroen J.W.M. Janssen, MD, PhD; Satu Mustjoki, MD, PhD; Joaquin Martinez-Lopez, MD, PhD; Hanne Vestergaard, MD, PhD; Hans Ehrencrona, MD, PhD; Katerina Machová Polákova, MD, PhD; Ulla Olsson-Str¨omberg, MD, PhD; Gert Ossenkoppele, MD, PhD; Marc G. Berger, MD, PhD; Gabriel Etienne, MD, PhD; Jolanta Dengler, MD, PhD; Tim H. Br¨ummendorf, MD, PhD; Andreas Burchert, MD, PhD; Delphine Réa, MD, PhD; Philippe Rousselot, MD, PhD; Franck E. Nicolini, MD, PhD; Wolf-Karsten Hofmann, MD, PhD; Johan Richter, MD, PhD; and Susanne Saussele, MD, PhD; on behalf of the EURO-SKI Investigators |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1915643589 | ||
| 003 | DE-627 | ||
| 005 | 20250716224413.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250127s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1200/JCO.23.01647 |2 doi | |
| 035 | |a (DE-627)1915643589 | ||
| 035 | |a (DE-599)KXP1915643589 | ||
| 035 | |a (OCoLC)1528017455 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mahon, François-Xavier |e VerfasserIn |0 (DE-588)1073303195 |0 (DE-627)828822298 |0 (DE-576)434864706 |4 aut | |
| 245 | 1 | 0 | |a European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia |b Final analysis and novel prognostic factors for treatment-free remission |c Francois-Xavier Mahon, MD, PhD; Markus Pfirrmann, PhD; Stéphanie Dulucq, PhD; Andreas Hochhaus, MD, PhD; Panayiotis Panayiotidis, MD, PhD; Antonio Almeida, MD, PhD; Jiri Mayer, MD, PhD; Henrik Hjorth-Hansen, MD, PhD; Jeroen J.W.M. Janssen, MD, PhD; Satu Mustjoki, MD, PhD; Joaquin Martinez-Lopez, MD, PhD; Hanne Vestergaard, MD, PhD; Hans Ehrencrona, MD, PhD; Katerina Machová Polákova, MD, PhD; Ulla Olsson-Str¨omberg, MD, PhD; Gert Ossenkoppele, MD, PhD; Marc G. Berger, MD, PhD; Gabriel Etienne, MD, PhD; Jolanta Dengler, MD, PhD; Tim H. Br¨ummendorf, MD, PhD; Andreas Burchert, MD, PhD; Delphine Réa, MD, PhD; Philippe Rousselot, MD, PhD; Franck E. Nicolini, MD, PhD; Wolf-Karsten Hofmann, MD, PhD; Johan Richter, MD, PhD; and Susanne Saussele, MD, PhD; on behalf of the EURO-SKI Investigators |
| 264 | 1 | |c June 1, 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 12. März, 2024 | ||
| 500 | |a Gesehen am 27.01.2025 | ||
| 520 | |a Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. - The European Stop Kinase Inhibitors (EURO-SKI) study is the largest clinical trial for investigating the cessation of tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukemia in stable deep molecular remission (DMR). Among 728 patients, 434 patients (61%; 95% CI, 57 to 64) remained in major molecular response (MMR) at 6 months and 309 patients of 678 (46%; 95% CI, 42 to 49) at 36 months. Duration of TKI treatment and DMR before TKI stop were confirmed as significant factors for the prediction of MMR loss at 6 months. In addition, the type of BCR::ABL1 transcript was identified as a prognostic factor. For late MMR losses after 6 months, TKI treatment duration, percentage of blasts in peripheral blood, and platelet count at diagnosis were significant factors in multivariate analysis. For the entire study period of 36 months, multiple logistic regression models confirmed duration of treatment, blasts, and transcript type as independent factors for MMR maintenance. In addition to the duration of treatment, transcript type as well as blasts in peripheral blood at diagnosis should be considered as important factors to predict treatment-free remission. | ||
| 700 | 1 | |a Pfirrmann, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dulucq, Stéphanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hochhaus, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Panayiotidis, Panayiotis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Almeida, Antonio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mayer, Jiri |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hjorth-Hansen, Henrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Janssen, Jeroen J.W.M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mustjoki, Satu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinez-Lopez, Joaquin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vestergaard, Hanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ehrencrona, Hans |e VerfasserIn |4 aut | |
| 700 | 1 | |a Machová Poláková, Katerina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Olsson-Strömberg, Ulla |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ossenkoppele, Gert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Berger, Marc G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Etienne, Gabriel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dengler, Jolanta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brümmendorf, Tim H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Burchert, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Réa, Delphine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rousselot, Philippe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nicolini, Franck E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hofmann, Wolf-Karsten |d 1967- |e VerfasserIn |0 (DE-588)114154635 |0 (DE-627)691208751 |0 (DE-576)351568336 |4 aut | |
| 700 | 1 | |a Richter, Johan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Saußele, Susanne |d 1968- |e VerfasserIn |0 (DE-588)115839860 |0 (DE-627)69162786X |0 (DE-576)29010694X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical oncology |d Alexandria, Va. : American Society of Clinical Oncology, 1983 |g 42(2024), 16, Seite 1875-1880 |h Online-Ressource |w (DE-627)313116962 |w (DE-600)2005181-5 |w (DE-576)090887018 |x 1527-7755 |7 nnas |a European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia Final analysis and novel prognostic factors for treatment-free remission |
| 773 | 1 | 8 | |g volume:42 |g year:2024 |g number:16 |g pages:1875-1880 |g extent:11 |a European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia Final analysis and novel prognostic factors for treatment-free remission |
| 856 | 4 | 0 | |u https://doi.org/10.1200/JCO.23.01647 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://ascopubs.org/doi/10.1200/JCO.23.01647 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250127 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 115839860 |a Saußele, Susanne |m 115839860:Saußele, Susanne |d 60000 |d 61200 |d 60000 |e 60000PS115839860 |e 61200PS115839860 |e 60000PS115839860 |k 0/60000/ |k 1/60000/61200/ |k 0/60000/ |p 27 |y j | ||
| 998 | |g 114154635 |a Hofmann, Wolf-Karsten |m 114154635:Hofmann, Wolf-Karsten |d 60000 |d 61200 |e 60000PH114154635 |e 61200PH114154635 |k 0/60000/ |k 1/60000/61200/ |p 25 | ||
| 999 | |a KXP-PPN1915643589 |e 4656582816 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"François-Xavier","family":"Mahon","display":"Mahon, François-Xavier"},{"family":"Pfirrmann","display":"Pfirrmann, Markus","role":"aut","given":"Markus"},{"role":"aut","given":"Stéphanie","display":"Dulucq, Stéphanie","family":"Dulucq"},{"role":"aut","given":"Andreas","display":"Hochhaus, Andreas","family":"Hochhaus"},{"role":"aut","given":"Panayiotis","display":"Panayiotidis, Panayiotis","family":"Panayiotidis"},{"given":"Antonio","role":"aut","family":"Almeida","display":"Almeida, Antonio"},{"display":"Mayer, Jiri","family":"Mayer","role":"aut","given":"Jiri"},{"display":"Hjorth-Hansen, Henrik","family":"Hjorth-Hansen","role":"aut","given":"Henrik"},{"display":"Janssen, Jeroen J.W.M.","family":"Janssen","given":"Jeroen J.W.M.","role":"aut"},{"family":"Mustjoki","display":"Mustjoki, Satu","role":"aut","given":"Satu"},{"role":"aut","given":"Joaquin","family":"Martinez-Lopez","display":"Martinez-Lopez, Joaquin"},{"given":"Hanne","role":"aut","family":"Vestergaard","display":"Vestergaard, Hanne"},{"display":"Ehrencrona, Hans","family":"Ehrencrona","role":"aut","given":"Hans"},{"role":"aut","given":"Katerina","display":"Machová Poláková, Katerina","family":"Machová Poláková"},{"role":"aut","given":"Ulla","family":"Olsson-Strömberg","display":"Olsson-Strömberg, Ulla"},{"family":"Ossenkoppele","display":"Ossenkoppele, Gert","role":"aut","given":"Gert"},{"given":"Marc G.","role":"aut","display":"Berger, Marc G.","family":"Berger"},{"role":"aut","given":"Gabriel","family":"Etienne","display":"Etienne, Gabriel"},{"given":"Jolanta","role":"aut","family":"Dengler","display":"Dengler, Jolanta"},{"role":"aut","given":"Tim H.","display":"Brümmendorf, Tim H.","family":"Brümmendorf"},{"family":"Burchert","display":"Burchert, Andreas","role":"aut","given":"Andreas"},{"given":"Delphine","role":"aut","family":"Réa","display":"Réa, Delphine"},{"display":"Rousselot, Philippe","family":"Rousselot","role":"aut","given":"Philippe"},{"family":"Nicolini","display":"Nicolini, Franck E.","role":"aut","given":"Franck E."},{"role":"aut","given":"Wolf-Karsten","family":"Hofmann","display":"Hofmann, Wolf-Karsten"},{"display":"Richter, Johan","family":"Richter","role":"aut","given":"Johan"},{"display":"Saußele, Susanne","family":"Saußele","given":"Susanne","role":"aut"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Online veröffentlicht: 12. März, 2024","Gesehen am 27.01.2025"],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"June 1, 2024"}],"title":[{"subtitle":"Final analysis and novel prognostic factors for treatment-free remission","title_sort":"European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia","title":"European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia"}],"id":{"doi":["10.1200/JCO.23.01647"],"eki":["1915643589"]},"name":{"displayForm":["Francois-Xavier Mahon, MD, PhD; Markus Pfirrmann, PhD; Stéphanie Dulucq, PhD; Andreas Hochhaus, MD, PhD; Panayiotis Panayiotidis, MD, PhD; Antonio Almeida, MD, PhD; Jiri Mayer, MD, PhD; Henrik Hjorth-Hansen, MD, PhD; Jeroen J.W.M. Janssen, MD, PhD; Satu Mustjoki, MD, PhD; Joaquin Martinez-Lopez, MD, PhD; Hanne Vestergaard, MD, PhD; Hans Ehrencrona, MD, PhD; Katerina Machová Polákova, MD, PhD; Ulla Olsson-Str¨omberg, MD, PhD; Gert Ossenkoppele, MD, PhD; Marc G. Berger, MD, PhD; Gabriel Etienne, MD, PhD; Jolanta Dengler, MD, PhD; Tim H. Br¨ummendorf, MD, PhD; Andreas Burchert, MD, PhD; Delphine Réa, MD, PhD; Philippe Rousselot, MD, PhD; Franck E. Nicolini, MD, PhD; Wolf-Karsten Hofmann, MD, PhD; Johan Richter, MD, PhD; and Susanne Saussele, MD, PhD; on behalf of the EURO-SKI Investigators"]},"physDesc":[{"noteIll":"Illustrationen","extent":"11 S."}],"relHost":[{"id":{"eki":["313116962"],"zdb":["2005181-5"],"issn":["1527-7755"]},"recId":"313116962","physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"European Stop Tyrosine Kinase Inhibitor trial (EURO-SKI) in chronic myeloid leukemia Final analysis and novel prognostic factors for treatment-free remissionJournal of clinical oncology","note":["Fortsetzung der Druck-Ausgabe","Gesehen am 22.05.23"],"origin":[{"publisherPlace":"Alexandria, Va. ; Baltimore, Md. [u.a.]","dateIssuedDisp":"1983-","publisher":"American Society of Clinical Oncology ; Lippincott Williams & Wilkins","dateIssuedKey":"1983"}],"pubHistory":["1.1983 -"],"title":[{"title_sort":"Journal of clinical oncology","subtitle":"JCO : an American Society of Clinical Oncology journal","title":"Journal of clinical oncology"}],"part":{"pages":"1875-1880","year":"2024","issue":"16","text":"42(2024), 16, Seite 1875-1880","volume":"42","extent":"11"},"titleAlt":[{"title":"official journal of the American Society of Clinical Oncology"},{"title":"JCO"},{"title":"Journal of clinical oncology legacy archive (ASCO)"}],"language":["eng"],"corporate":[{"display":"American Society of Clinical Oncology","role":"isb"}]}],"recId":"1915643589"} | ||
| SRT | |a MAHONFRANCEUROPEANST1202 | ||