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3D analysis of microvasculature in murine liver fibrosis models using synchrotron radiation-based microtomography

Cirrhosis describes the development of excess fibrous tissue around regenerative nodules in response to chronic liver injury and usually leads to irreversible organ damage and end-stage liver disease. During the development of cirrhosis, the formation of collagenous scar tissue is paralleled by a re...

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Bibliographic Details
Main Authors: Wagner, Willi Linus (Author) , Föhst, Sonja (Author) , Hock, Jessica (Author) , Kim, Yong Ook (Author) , Popov, Yury (Author) , Schuppan, Detlef (Author) , Schladitz, Katja (Author) , Redenbach, Claudia (Author) , Ackermann, Maximilian (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Angiogenesis
Year: 2021, Volume: 24, Pages: 57-65
ISSN:1573-7209
DOI:10.1007/s10456-020-09751-9
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Author Notes:Willi L. Wagner, Sonja Föhst, Jessica Hock, Yong Ook Kim, Yury Popov, Detlef Schuppan, Katja Schladitz, Claudia Redenbach, Maximilian Ackermann
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Summary:Cirrhosis describes the development of excess fibrous tissue around regenerative nodules in response to chronic liver injury and usually leads to irreversible organ damage and end-stage liver disease. During the development of cirrhosis, the formation of collagenous scar tissue is paralleled by a reorganization and remodeling of the hepatic vascular system. To date, macrovascular remodeling in various cirrhosis models has been examined using three-dimensional (3D) imaging modalities, while microvascular changes have been studied mainly by two-dimensional (2D) light microscopic and electron microscopic imaging. Here, we report on the application of high-resolution 3D synchrotron radiation-based microtomography (SRμCT) for the study of the sinusoidal and capillary blood vessel system in three murine models of advanced parenchymal and biliary hepatic fibrosis. SRμCT facilitates the characterization of microvascular architecture and identifies features of intussusceptive angiogenesis in progressive liver fibrosis in a non-destructive 3D manner.
Item Description:Online publiziert: 10. Oktober 2020
Gesehen am 27.01.2025
Physical Description:Online Resource
ISSN:1573-7209
DOI:10.1007/s10456-020-09751-9

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