A fatty acid switch drives ferroptosis in EMT
Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to elimi...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2024
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| In: |
Nature cell biology
Year: 2024, Volume: 26, Issue: 9, Pages: 1375-1376 |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/s41556-024-01483-y |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41556-024-01483-y Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41556-024-01483-y 
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| Author Notes: | Alina M. Winkelkotte & Almut Schulze |
MARC
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| 520 | |a Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to eliminate aggressive mesenchymal cancer cells. | ||
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