Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype
Formation of organo-typical vascular networks requires cross-talk between differentiating parenchymal cells and developing blood vessels. Here we identify a Vegfa driven venous sprouting process involving parenchymal to vein cross-talk regulating venous endothelial Vegfa signaling strength and subse...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 April 2024
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| In: |
Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-22 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-47434-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-024-47434-x
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| Verfasserangaben: | Laetitia Préau, Anna Lischke, Melanie Merkel, Neslihan Oegel, Maria Weissenbruch, Andria Michael, Hongryeol Park, Dietmar Gradl, Christian Kupatt & Ferdinand le Noble |
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| 245 | 1 | 0 | |a Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype |c Laetitia Préau, Anna Lischke, Melanie Merkel, Neslihan Oegel, Maria Weissenbruch, Andria Michael, Hongryeol Park, Dietmar Gradl, Christian Kupatt & Ferdinand le Noble |
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| 520 | |a Formation of organo-typical vascular networks requires cross-talk between differentiating parenchymal cells and developing blood vessels. Here we identify a Vegfa driven venous sprouting process involving parenchymal to vein cross-talk regulating venous endothelial Vegfa signaling strength and subsequent formation of a specialized angiogenic cell, prefabricated with an intact lumen and pericyte coverage, termed L-Tip cell. L-Tip cell selection in the venous domain requires genetic interaction between vascular Aplnra and Kdrl in a subset of venous endothelial cells and exposure to parenchymal derived Vegfa and Apelin. Parenchymal Esm1 controls the spatial positioning of venous sprouting by fine-tuning local Vegfa availability. These findings may provide a conceptual framework for understanding how Vegfa generates organo-typical vascular networks based on the selection of competent endothelial cells, induced via spatio-temporal control of endothelial Kdrl signaling strength involving multiple parenchymal derived cues generated in a tissue dependent metabolic context. | ||
| 650 | 4 | |a Angiogenesis | |
| 650 | 4 | |a Endothelial Cells | |
| 650 | 4 | |a Neovascularization, Physiologic | |
| 650 | 4 | |a Veins | |
| 700 | 1 | |a Lischke, Anna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Merkel, Melanie |e VerfasserIn |4 aut | |
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