Apolipoprotein E polymorphism and renal function in German Type 1 and Type 2 diabetic patients
To examine the association of renal function in diabetic patients with apolipoprotein (apo) E polymorphism.Apo E genotypes, lipid and lipoprotein serum levels, creatinine clearance (CCr), and excretion of marker proteins were determined in German type 1 (IDDM; n = 162) and type 2 (NIDDM; n = 124) di...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 01 1998
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| In: |
Diabetes care
Year: 1998, Jahrgang: 21, Heft: 6, Pages: 994-998 |
| ISSN: | 1935-5548 |
| DOI: | 10.2337/diacare.21.6.994 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/diacare.21.6.994
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| Verfasserangaben: | Egon Werle, Walter Fiehn, Christoph Hasslacher |
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| 520 | |a To examine the association of renal function in diabetic patients with apolipoprotein (apo) E polymorphism.Apo E genotypes, lipid and lipoprotein serum levels, creatinine clearance (CCr), and excretion of marker proteins were determined in German type 1 (IDDM; n = 162) and type 2 (NIDDM; n = 124) diabetic patients. Albumin and immunoglobulin (Ig) G are considered to reflect charge-size permselectivity of the glomerular capillary basement membrane, and increased alpha 1-microglobulin (MG) excretion indicates compromised reabsorptive capacity of the renal tubules.Patients with NIDDM had higher lipid levels and lower CCrs than patients with IDDM. In patients with IDDM, age- and sex-adjusted analysis of variance showed an association between apo E genotypes and CCr, and the Jonckheere-Terpstra test demonstrated a decreasing glomerular filtration rate in the following order of genotypes: ε4ε4/ε4ε3 > ε3ε3 > ε2ε2/ε2ε3. Multiple linear regression analyses revealed that in patients with IDDM, the ε2 allele was a negative predictor of CCr and a positive predictor of urinary excretion of albumin, IgG and α 1-MG independent from HDL and LDL cholesterol, TG concentration, age, and sex.Apo E polymorphism influences serum lipoprotein levels in patients with IDDM and NIDDM. Apo E polymorphism may be a renal risk factor of clinical relevance in normolipidemic patients with IDDM. | ||
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