Cover Image

The molecular and immunological landscape of meningiomas: review

Meningiomas are the most common primary intracranial tumors in adults and typically have a slow-growing and benign nature. However, there is also a substantial subset of meningiomas that shows aggressive clinical behavior and is refractory to standard treatment modalities, which are still limited to...

Full description

Saved in:
Bibliographic Details
Main Authors: Lotsch, Catharina (Author) , Warta, Rolf (Author) , Herold-Mende, Christel (Author)
Format: Article (Journal)
Language:English
Published: 5 September 2024
In: International journal of molecular sciences
Year: 2024, Volume: 25, Issue: 17, Pages: 1-13
ISSN:1422-0067
DOI:10.3390/ijms25179631
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms25179631
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/25/17/9631
Get full text
Author Notes:Catharina Lotsch, Rolf Warta and Christel Herold-Mende

MARC

LEADER 00000caa a2200000 c 4500
001 1916868517
003 DE-627
005 20250716231253.0
007 cr uuu---uuuuu
008 250211s2024 xx |||||o 00| ||eng c
024 7 |a 10.3390/ijms25179631  |2 doi 
035 |a (DE-627)1916868517 
035 |a (DE-599)KXP1916868517 
035 |a (OCoLC)1528018922 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Lotsch, Catharina  |d 1994-  |e VerfasserIn  |0 (DE-588)1317785843  |0 (DE-627)1879634805  |4 aut 
245 1 4 |a The molecular and immunological landscape of meningiomas  |b review  |c Catharina Lotsch, Rolf Warta and Christel Herold-Mende 
246 1 |i Titel des special issue  |a Biomarkers, Treatments, and Clinical Outcomes for Meningiomas and Other Skull Base Tumors 
264 1 |c 5 September 2024 
300 |b Illustrationen 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 11.02.2025 
520 |a Meningiomas are the most common primary intracranial tumors in adults and typically have a slow-growing and benign nature. However, there is also a substantial subset of meningiomas that shows aggressive clinical behavior and is refractory to standard treatment modalities, which are still limited to surgery and/or radiotherapy. Despite intensive research, no systemic treatment options are yet available in the clinic for these challenging tumors, resulting in poor patient outcome. Intensive research on the molecular pathogenesis of meningiomas has led to improved diagnostic tools, but so far there is no standardized implementation for the molecular profiling of these tumors for clinical practice. Recent research advances have also focused on the immunophenotyping of meningiomas, leading to several clinical trials examining the use of immune checkpoint blockade therapy in patients with clinically aggressive subtypes. In this review, we aim to summarize the current knowledge on the molecular and immunological landscape of meningiomas in detail and provide current and progressive ideas for future directions. 
650 4 |a brain tumor diagnostics 
650 4 |a DNA methylation 
650 4 |a immunobiology 
650 4 |a immunotherapy 
650 4 |a infiltrating immune cells 
650 4 |a meningioma 
650 4 |a meningioma prognosis 
650 4 |a molecular profiling 
700 1 |a Warta, Rolf  |d 1980-  |e VerfasserIn  |0 (DE-588)1047472260  |0 (DE-627)778430839  |0 (DE-576)401088030  |4 aut 
700 1 |a Herold-Mende, Christel  |e VerfasserIn  |0 (DE-588)1022936549  |0 (DE-627)717335577  |0 (DE-576)366194267  |4 aut 
773 0 8 |i Enthalten in  |t International journal of molecular sciences  |d Basel : Molecular Diversity Preservation International, 2000  |g 25(2024), 17, special issue, Artikel-ID 9631, Seite 1-13  |h Online-Ressource  |w (DE-627)316340715  |w (DE-600)2019364-6  |w (DE-576)281194653  |x 1422-0067  |7 nnas  |a The molecular and immunological landscape of meningiomas review 
773 1 8 |g volume:25  |g year:2024  |g number:17  |g supplement:special issue  |g elocationid:9631  |g pages:1-13  |g extent:13  |a The molecular and immunological landscape of meningiomas review 
856 4 0 |u https://doi.org/10.3390/ijms25179631  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.mdpi.com/1422-0067/25/17/9631  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20250211 
993 |a Article 
994 |a 2024 
998 |g 1022936549  |a Herold-Mende, Christel  |m 1022936549:Herold-Mende, Christel  |d 910000  |d 911200  |e 910000PH1022936549  |e 911200PH1022936549  |k 0/910000/  |k 1/910000/911200/  |p 3  |y j 
998 |g 1047472260  |a Warta, Rolf  |m 1047472260:Warta, Rolf  |d 910000  |d 911200  |e 910000PW1047472260  |e 911200PW1047472260  |k 0/910000/  |k 1/910000/911200/  |p 2 
998 |g 1317785843  |a Lotsch, Catharina  |m 1317785843:Lotsch, Catharina  |d 910000  |d 911200  |e 910000PL1317785843  |e 911200PL1317785843  |k 0/910000/  |k 1/910000/911200/  |p 1  |x j 
999 |a KXP-PPN1916868517  |e 4663177085 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"part":{"extent":"13","issue":"17","pages":"1-13","year":"2024","volume":"25","text":"25(2024), 17, special issue, Artikel-ID 9631, Seite 1-13"},"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["316340715"],"zdb":["2019364-6"],"issn":["1422-0067","1661-6596"]},"recId":"316340715","origin":[{"publisher":"Molecular Diversity Preservation International","dateIssuedDisp":"2000-","publisherPlace":"Basel","dateIssuedKey":"2000"}],"disp":"The molecular and immunological landscape of meningiomas reviewInternational journal of molecular sciences","language":["eng"],"pubHistory":["1.2000 -"],"titleAlt":[{"title":"IJMS"}],"note":["Gesehen am 17.09.20"]}],"physDesc":[{"noteIll":"Illustrationen","extent":"13 S."}],"title":[{"title":"The molecular and immunological landscape of meningiomas","subtitle":"review","title_sort":"molecular and immunological landscape of meningiomas"}],"id":{"doi":["10.3390/ijms25179631"],"eki":["1916868517"]},"recId":"1916868517","type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"5 September 2024"}],"name":{"displayForm":["Catharina Lotsch, Rolf Warta and Christel Herold-Mende"]},"titleAlt":[{"title":"Biomarkers, Treatments, and Clinical Outcomes for Meningiomas and Other Skull Base Tumors"}],"note":["Gesehen am 11.02.2025"],"language":["eng"],"person":[{"display":"Lotsch, Catharina","role":"aut","family":"Lotsch","given":"Catharina"},{"display":"Warta, Rolf","family":"Warta","role":"aut","given":"Rolf"},{"given":"Christel","display":"Herold-Mende, Christel","role":"aut","family":"Herold-Mende"}]} 
SRT |a LOTSCHCATHMOLECULARA5202 

Similar Items