A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL
Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)‐mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we rep...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 15, 1996
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| In: |
The EMBO journal
Year: 1996, Jahrgang: 15, Heft: 22, Pages: 6166-6171 |
| ISSN: | 1460-2075 |
| DOI: | 10.1002/j.1460-2075.1996.tb01004.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/j.1460-2075.1996.tb01004.x Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/abs/10.1002/j.1460-2075.1996.tb01004.x 
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| Verfasserangaben: | Stephan Philipp, Adolfo Cavalié, Marc Freichel, Ulrich Wissenbach, Stephanie Zimmer, Claudia Trost, Andrea Marquart, Manabu Murakami, Veit Flockerzi |
| Zusammenfassung: | Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)‐mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP3 or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP3 signalling. |
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| Beschreibung: | Gesehen am 12.02.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1460-2075 |
| DOI: | 10.1002/j.1460-2075.1996.tb01004.x |