A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL
Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)‐mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we rep...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 15, 1996
|
| In: |
The EMBO journal
Year: 1996, Volume: 15, Issue: 22, Pages: 6166-6171 |
| ISSN: | 1460-2075 |
| DOI: | 10.1002/j.1460-2075.1996.tb01004.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/j.1460-2075.1996.tb01004.x Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/abs/10.1002/j.1460-2075.1996.tb01004.x 
|
| Author Notes: | Stephan Philipp, Adolfo Cavalié, Marc Freichel, Ulrich Wissenbach, Stephanie Zimmer, Claudia Trost, Andrea Marquart, Manabu Murakami, Veit Flockerzi |
| Summary: | Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)‐mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP3 or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP3 signalling. |
|---|---|
| Item Description: | Gesehen am 12.02.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1460-2075 |
| DOI: | 10.1002/j.1460-2075.1996.tb01004.x |