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Contrast agent-free functional magnetic resonance imaging with matrix pencil decomposition to quantify abnormalities in lung perfusion and ventilation in patients with cystic fibrosis

BACKGROUND: Previous studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-MRI) enables quantification of lung perfusion and...

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Autori principali: Döllinger, Felix (Autore) , Bauman, Grzegorz (Autore) , Roehmel, Jobst (Autore) , Stahl, Mirjam (Autore) , Posch, Helena (Autore) , Steffen, Ingo G. (Autore) , Pusterla, Orso (Autore) , Bieri, Oliver (Autore) , Wielpütz, Mark Oliver (Autore) , Mall, Marcus A. (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 05 June 2024
In: Frontiers in medicine
Year: 2024, Volume: 11, Pages: 1-14
ISSN:2296-858X
DOI:10.3389/fmed.2024.1349466
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2024.1349466
Testo
Note sull'autore:Felix Doellinger, Grzegorz Bauman, Jobst Roehmel, Mirjam Stahl, Helena Posch, Ingo G. Steffen, Orso Pusterla, Oliver Bieri, Mark O. Wielpütz and Marcus A. Mall
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Riassunto:BACKGROUND: Previous studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-MRI) enables quantification of lung perfusion and ventilation without intravenous contrast agent administration. - OBJECTIVES: To compare MP-MRI with established morpho-functional MRI and spirometry in patients with CF. - METHODS: Thirty-nine clinically stable patients with CF (mean age 21.6 ± 10.7 years, range 8-45 years) prospectively underwent morpho-functional MRI including CE perfusion MRI, MP-MRI and spirometry. Two blinded chest radiologists assessed morpho-functional MRI and MP-MRI employing the validated chest MRI score. In addition, MP-MRI data were processed by automated software calculating perfusion defect percentage (QDP) and ventilation defect percentage (VDP). - RESULTS: MP perfusion score and QDP correlated strongly with the CE perfusion score (both r = 0.81; p < 0.01). MP ventilation score and VDP showed strong inverse correlations with percent predicted FEV1 (r = -0.75 and r = -0.83; p < 0.01). The comparison of visual and automated parameters showed that both MP perfusion score and QDP, and MP ventilation score and VDP were strongly correlated (r = 0.74 and r = 0.78; both p < 0.01). Further, the MP perfusion score and MP ventilation score, as well as QDP and VDP were strongly correlated (r = 0.88 and r = 0.86; both p < 0.01). - CONCLUSION: MP-MRI detects abnormalities in lung perfusion and ventilation in patients with CF without intravenous or inhaled contrast agent application, and correlates strongly with the well-established CE perfusion MRI score and spirometry. Automated analysis of MP-MRI may serve as quantitative noninvasive outcome measure for diagnostic monitoring and clinical trials.
Descrizione del documento:Gesehen am 13.02.2025
Descrizione fisica:Online Resource
ISSN:2296-858X
DOI:10.3389/fmed.2024.1349466

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