Contrast agent-free functional magnetic resonance imaging with matrix pencil decomposition to quantify abnormalities in lung perfusion and ventilation in patients with cystic fibrosis
BACKGROUND: Previous studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-MRI) enables quantification of lung perfusion and...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 June 2024
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| In: |
Frontiers in medicine
Year: 2024, Volume: 11, Pages: 1-14 |
| ISSN: | 2296-858X |
| DOI: | 10.3389/fmed.2024.1349466 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2024.1349466
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| Author Notes: | Felix Doellinger, Grzegorz Bauman, Jobst Roehmel, Mirjam Stahl, Helena Posch, Ingo G. Steffen, Orso Pusterla, Oliver Bieri, Mark O. Wielpütz and Marcus A. Mall |
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| 245 | 1 | 0 | |a Contrast agent-free functional magnetic resonance imaging with matrix pencil decomposition to quantify abnormalities in lung perfusion and ventilation in patients with cystic fibrosis |c Felix Doellinger, Grzegorz Bauman, Jobst Roehmel, Mirjam Stahl, Helena Posch, Ingo G. Steffen, Orso Pusterla, Oliver Bieri, Mark O. Wielpütz and Marcus A. Mall |
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| 520 | |a BACKGROUND: Previous studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-MRI) enables quantification of lung perfusion and ventilation without intravenous contrast agent administration. - OBJECTIVES: To compare MP-MRI with established morpho-functional MRI and spirometry in patients with CF. - METHODS: Thirty-nine clinically stable patients with CF (mean age 21.6 ± 10.7 years, range 8-45 years) prospectively underwent morpho-functional MRI including CE perfusion MRI, MP-MRI and spirometry. Two blinded chest radiologists assessed morpho-functional MRI and MP-MRI employing the validated chest MRI score. In addition, MP-MRI data were processed by automated software calculating perfusion defect percentage (QDP) and ventilation defect percentage (VDP). - RESULTS: MP perfusion score and QDP correlated strongly with the CE perfusion score (both r = 0.81; p < 0.01). MP ventilation score and VDP showed strong inverse correlations with percent predicted FEV1 (r = -0.75 and r = -0.83; p < 0.01). The comparison of visual and automated parameters showed that both MP perfusion score and QDP, and MP ventilation score and VDP were strongly correlated (r = 0.74 and r = 0.78; both p < 0.01). Further, the MP perfusion score and MP ventilation score, as well as QDP and VDP were strongly correlated (r = 0.88 and r = 0.86; both p < 0.01). - CONCLUSION: MP-MRI detects abnormalities in lung perfusion and ventilation in patients with CF without intravenous or inhaled contrast agent application, and correlates strongly with the well-established CE perfusion MRI score and spirometry. Automated analysis of MP-MRI may serve as quantitative noninvasive outcome measure for diagnostic monitoring and clinical trials. | ||
| 650 | 4 | |a cystic fibrosis | |
| 650 | 4 | |a functional imaging | |
| 650 | 4 | |a magnetic resonance imaging | |
| 650 | 4 | |a matrix pencil decomposition | |
| 650 | 4 | |a quantitative imaging | |
| 700 | 1 | |a Bauman, Grzegorz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Roehmel, Jobst |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stahl, Mirjam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Posch, Helena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steffen, Ingo G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pusterla, Orso |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bieri, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wielpütz, Mark Oliver |d 1982- |e VerfasserIn |0 (DE-588)139999752 |0 (DE-627)614754682 |0 (DE-576)314127046 |4 aut | |
| 700 | 1 | |a Mall, Marcus A. |e VerfasserIn |4 aut | |
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