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Contrast agent-free functional magnetic resonance imaging with matrix pencil decomposition to quantify abnormalities in lung perfusion and ventilation in patients with cystic fibrosis

BACKGROUND: Previous studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-MRI) enables quantification of lung perfusion and...

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Hauptverfasser: Döllinger, Felix (VerfasserIn) , Bauman, Grzegorz (VerfasserIn) , Roehmel, Jobst (VerfasserIn) , Stahl, Mirjam (VerfasserIn) , Posch, Helena (VerfasserIn) , Steffen, Ingo G. (VerfasserIn) , Pusterla, Orso (VerfasserIn) , Bieri, Oliver (VerfasserIn) , Wielpütz, Mark Oliver (VerfasserIn) , Mall, Marcus A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 05 June 2024
In: Frontiers in medicine
Year: 2024, Jahrgang: 11, Pages: 1-14
ISSN:2296-858X
DOI:10.3389/fmed.2024.1349466
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2024.1349466
Volltext
Verfasserangaben:Felix Doellinger, Grzegorz Bauman, Jobst Roehmel, Mirjam Stahl, Helena Posch, Ingo G. Steffen, Orso Pusterla, Oliver Bieri, Mark O. Wielpütz and Marcus A. Mall
Beschreibung
Zusammenfassung:BACKGROUND: Previous studies showed that contrast-enhanced (CE) morpho-functional magnetic resonance imaging (MRI) detects abnormalities in lung morphology and perfusion in patients with cystic fibrosis (CF). Novel matrix pencil decomposition MRI (MP-MRI) enables quantification of lung perfusion and ventilation without intravenous contrast agent administration. - OBJECTIVES: To compare MP-MRI with established morpho-functional MRI and spirometry in patients with CF. - METHODS: Thirty-nine clinically stable patients with CF (mean age 21.6 ± 10.7 years, range 8-45 years) prospectively underwent morpho-functional MRI including CE perfusion MRI, MP-MRI and spirometry. Two blinded chest radiologists assessed morpho-functional MRI and MP-MRI employing the validated chest MRI score. In addition, MP-MRI data were processed by automated software calculating perfusion defect percentage (QDP) and ventilation defect percentage (VDP). - RESULTS: MP perfusion score and QDP correlated strongly with the CE perfusion score (both r = 0.81; p < 0.01). MP ventilation score and VDP showed strong inverse correlations with percent predicted FEV1 (r = -0.75 and r = -0.83; p < 0.01). The comparison of visual and automated parameters showed that both MP perfusion score and QDP, and MP ventilation score and VDP were strongly correlated (r = 0.74 and r = 0.78; both p < 0.01). Further, the MP perfusion score and MP ventilation score, as well as QDP and VDP were strongly correlated (r = 0.88 and r = 0.86; both p < 0.01). - CONCLUSION: MP-MRI detects abnormalities in lung perfusion and ventilation in patients with CF without intravenous or inhaled contrast agent application, and correlates strongly with the well-established CE perfusion MRI score and spirometry. Automated analysis of MP-MRI may serve as quantitative noninvasive outcome measure for diagnostic monitoring and clinical trials.
Beschreibung:Gesehen am 13.02.2025
Beschreibung:Online Resource
ISSN:2296-858X
DOI:10.3389/fmed.2024.1349466

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