The influence of contrast media on calcium-based imaging of the spine in dual-layer CT
This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, t...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 August 2024
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| In: |
Scientific reports
Year: 2024, Jahrgang: 14, Pages: 1-10 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-024-69743-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-024-69743-3 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-024-69743-3 
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| Verfasserangaben: | S. Rahn, S. Skornitzke, C. Melzig, T. Reiner, W. Stiller, C.P. Heussel, H.U. Kauczor, T.F. Weber & T.D. Do |
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| 245 | 1 | 4 | |a The influence of contrast media on calcium-based imaging of the spine in dual-layer CT |c S. Rahn, S. Skornitzke, C. Melzig, T. Reiner, W. Stiller, C.P. Heussel, H.U. Kauczor, T.F. Weber & T.D. Do |
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| 520 | |a This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, true non-contrast (TNC) and venous phase images (VP) of n = 97 patients were acquired. CT attenuation of the first lumbar vertebra (L1) was measured in TNC-VCa, VP-VCa, and in virtual non-contrast images (VNC). CT attenuation was significantly higher in VP-VCa than in TNC-VCa (p < 0.001), although regression analyses revealed a strong linear association between these measures (R2 = 0.84). A statistical model for the prediction of TNC-VCa CT attenuation was established (TNC-VCa[HU] = − 6.81 + 0.87 × VP-VCa[HU]-0.55 × body weight[kg]) and yielded good agreement between observed and predicted values. Furthermore, a L1 CT attenuation threshold of 293 HU in VP-VCa showed a sensitivity of 90% and a specificity of 96% for detecting osteoporosis. The application of contrast media leads to an overestimation of L1 CT attenuation in VCa. However, CT attenuation values from VP-VCa can be used within CT-based opportunistic osteoporosis screening eighter by applying a separate threshold of 293 HU or by converting measured data to TNC-VCa CT attenuation with the given regression equation. | ||
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