The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels
The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage activated (T-type) and high-voltage activated (L-type) Ca++ channels were compared. L-type barium currents were measured in Chinese hamster ovary cells stably transfected with the alpha 1 subunit of the class Cb Ca+...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 1994
|
| In: |
The journal of pharmacology and experimental therapeutics
Year: 1994, Jahrgang: 271, Heft: 3, Pages: 1483-1488 |
| ISSN: | 1521-0103 |
| DOI: | 10.1016/S0022-3565(25)24034-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0022-3565(25)24034-4 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022356525240344 
|
| Verfasserangaben: | G. Mehrke, X.G Zong, V. Flockerzi, F. Hofmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1917389272 | ||
| 003 | DE-627 | ||
| 005 | 20250716232216.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250217s1994 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S0022-3565(25)24034-4 |2 doi | |
| 035 | |a (DE-627)1917389272 | ||
| 035 | |a (DE-599)KXP1917389272 | ||
| 035 | |a (OCoLC)1528019259 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mehrke, Gerhard |e VerfasserIn |0 (DE-588)1356580645 |0 (DE-627)1917389701 |4 aut | |
| 245 | 1 | 4 | |a The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels |c G. Mehrke, X.G Zong, V. Flockerzi, F. Hofmann |
| 246 | 3 | 3 | |a The Ca(plus plus)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca plus plus channels |
| 264 | 1 | |c December 1994 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe 31. Januar 2025 | ||
| 500 | |a Gesehen am 17.02.2025 | ||
| 520 | |a The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage activated (T-type) and high-voltage activated (L-type) Ca++ channels were compared. L-type barium currents were measured in Chinese hamster ovary cells stably transfected with the alpha 1 subunit of the class Cb Ca++ channel. T-type barium currents were investigated in human medullary thyroid carcinoma cells. The Ba++ currents of human medullary thyroid carcinoma cells were transient, activated at a threshold potential of -50 mV with the maximum at -14 +/- 3.2 mV and blocked by micromolar Ni++. The T- and L-type current inactivated with time constants of 33.4 +/- 4.1 and 416 +/- 26 msec at maximum barium currents, respectively. Ro 40-5967 inhibited reversibly the T- and L-type currents with IC50 values of 2.7 and 18.6 microM, respectively. The inhibition of the L-type current was voltage-dependent, whereas that of the T-type current was not. Ro 40-5967 blocked T-type current already at a holding potential of -100 mV. The different types of block, i.e., voltage-dependent vs. tonic block, may contribute to the pharmacological profile of Ro 40-5967 in intact animals. | ||
| 700 | 1 | |a Zong, X. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Flockerzi, Veit |d 1955- |e VerfasserIn |0 (DE-588)1149409215 |0 (DE-627)1009648748 |0 (DE-576)496740466 |4 aut | |
| 700 | 1 | |a Hofmann, Franz |d 1942- |e VerfasserIn |0 (DE-588)136908268 |0 (DE-627)588332860 |0 (DE-576)301340064 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of pharmacology and experimental therapeutics |d Bethesda, Md. : ASPET, 1909 |g 271(1994), 3, Seite 1483-1488 |h Online-Ressource |w (DE-627)269534636 |w (DE-600)1475023-5 |w (DE-576)077884736 |x 1521-0103 |7 nnas |a The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels |
| 773 | 1 | 8 | |g volume:271 |g year:1994 |g number:3 |g pages:1483-1488 |g extent:6 |a The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0022-3565(25)24034-4 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0022356525240344 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250217 | ||
| 993 | |a Article | ||
| 994 | |a 1994 | ||
| 998 | |g 1149409215 |a Flockerzi, Veit |m 1149409215:Flockerzi, Veit |d 50000 |d 54600 |e 50000PF1149409215 |e 54600PF1149409215 |k 0/50000/ |k 1/50000/54600/ |p 3 | ||
| 999 | |a KXP-PPN1917389272 |e 4665013462 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1917389272","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Elektronische Reproduktion der Druck-Ausgabe 31. Januar 2025","Gesehen am 17.02.2025"],"titleAlt":[{"title":"The Ca(plus plus)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca plus plus channels"}],"person":[{"role":"aut","display":"Mehrke, Gerhard","roleDisplay":"VerfasserIn","given":"Gerhard","family":"Mehrke"},{"given":"X. G.","family":"Zong","role":"aut","roleDisplay":"VerfasserIn","display":"Zong, X. G."},{"family":"Flockerzi","given":"Veit","display":"Flockerzi, Veit","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Hofmann","given":"Franz","display":"Hofmann, Franz","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels","title_sort":"Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels"}],"relHost":[{"titleAlt":[{"title":"JPET online"}],"part":{"year":"1994","pages":"1483-1488","issue":"3","text":"271(1994), 3, Seite 1483-1488","volume":"271","extent":"6"},"pubHistory":["1.1909/10 -"],"language":["eng"],"recId":"269534636","type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channelsThe journal of pharmacology and experimental therapeutics","note":["Gesehen am 06.02.25","Fortsetzung der Druck-Ausgabe"],"title":[{"title":"The journal of pharmacology and experimental therapeutics","subtitle":"a publication of the American Society for Pharmacology and Experimental Therapeutics","title_sort":"journal of pharmacology and experimental therapeutics"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1521-0103"],"eki":["269534636"],"zdb":["1475023-5"]},"origin":[{"dateIssuedDisp":"1909-","publisher":"ASPET","dateIssuedKey":"1909","publisherPlace":"Bethesda, Md."}]}],"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["G. Mehrke, X.G Zong, V. Flockerzi, F. Hofmann"]},"id":{"eki":["1917389272"],"doi":["10.1016/S0022-3565(25)24034-4"]},"origin":[{"dateIssuedKey":"1994","dateIssuedDisp":"December 1994"}]} | ||
| SRT | |a MEHRKEGERHCACHANNELB1994 | ||