Time course of the interaction between oral short-term ritonavir therapy with three factor Xa inhibitors and the activity of CYP2D6, CYP2C19, and CYP3A4 in healthy volunteers
We investigated the effect of a 5-day low-dose ritonavir therapy, as it is used in the treatment of COVID-19 with nirmatrelvir/ritonavir, on the pharmacokinetics of three factor Xa inhibitors (FXaI). Concurrently, the time course of the activities of the cytochromes P450 (CYP) 3A4, 2C19, and 2D6 was...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 February 2024
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| In: |
Clinical pharmacokinetics
Year: 2024, Jahrgang: 63, Heft: 4, Pages: 469-481 |
| ISSN: | 1179-1926 |
| DOI: | 10.1007/s40262-024-01350-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s40262-024-01350-x
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| Verfasserangaben: | Brit S. Rohr, Evelyn Krohmer, Kathrin I. Foerster, Jürgen Burhenne, Martin Schulz, Antje Blank, Gerd Mikus, Walter E. Haefeli |
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| 520 | |a We investigated the effect of a 5-day low-dose ritonavir therapy, as it is used in the treatment of COVID-19 with nirmatrelvir/ritonavir, on the pharmacokinetics of three factor Xa inhibitors (FXaI). Concurrently, the time course of the activities of the cytochromes P450 (CYP) 3A4, 2C19, and 2D6 was assessed. | ||
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