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Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study)

Background: Data on cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited to studies with small sample sizes. Therefore, we aimed to analyse the extent, characteristics and the longitudinal course of potential cognitive deficits in patients wi...

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Main Authors: Passoke, Sarah (Author) , Stern, Carlotta (Author) , Häußler, Vivien (Author) , Kümpfel, Tania (Author) , Havla, Joachim (Author) , Engels, Daniel (Author) , Jarius, Sven (Author) , Wildemann, Brigitte (Author) , Korporal-Kuhnke, Mirjam (Author) , Senel, Makbule (Author) , Stellmann, Jan-Patrick (Author) , Warnke, Clemens (Author) , Grothe, Matthias (Author) , Schülke, Rasmus (Author) , Gingele, Stefan (Author) , Kretschmer, Julian Reza (Author) , Klotz, Luisa (Author) , Walter, Annette (Author) , Bergh, Florian Then (Author) , Aktas, Orhan (Author) , Ringelstein, Marius (Author) , Ayzenberg, Ilya (Author) , Schwake, Carolin (Author) , Kleiter, Ingo (Author) , Sperber, Pia Sophie (Author) , Rust, Rebekka (Author) , Schindler, Patrick (Author) , Bellmann-Strobl, Judith (Author) , Paul, Friedemann (Author) , Kopp, Bruno (Author) , Trebst, Corinna (Author) , Hümmert, Martin W. (Author)
Format: Article (Journal)
Language:English
Published: 30 July 2024
In: Journal of neurology, neurosurgery, and psychiatry
Year: 2025, Volume: 96, Issue: 3, Pages: 296-305
ISSN:1468-330X
DOI:10.1136/jnnp-2024-333994
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1136/jnnp-2024-333994
Verlag, kostenfrei, Volltext: https://jnnp.bmj.com/content/early/2024/07/30/jnnp-2024-333994
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Author Notes:Sarah Passoke, Carlotta Stern, Vivien Häußler, Tania Kümpfel, Joachim Havla, Daniel Engels, Sven Jarius, Brigitte Wildemann, Mirjam Korporal-Kuhnke, Makbule Senel, Jan-Patrick Stellmann, Clemens Warnke, Matthias Grothe, Rasmus Schülke, Stefan Gingele, Julian Reza Kretschmer, Luisa Klotz, Annette Walter, Florian Then Bergh, Orhan Aktas, Marius Ringelstein, Ilya Ayzenberg, Carolin Schwake, Ingo Kleiter, Pia Sophie Sperber, Rebekka Rust, Patrick Schindler, Judith Bellmann-Strobl, Friedemann Paul, Bruno Kopp, Corinna Trebst, Martin W. Hümmert, on behalf of the Neuromyelitis Optica Study Group (NEMOS)
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Summary:Background: Data on cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited to studies with small sample sizes. Therefore, we aimed to analyse the extent, characteristics and the longitudinal course of potential cognitive deficits in patients with MOGAD. - Methods: The CogniMOG-Study is a prospective, longitudinal and multicentre observational study of 113 patients with MOGAD. Individual cognitive performance was assessed using the Paced Auditory Serial Addition Task (PASAT), the Symbol Digit Modalities Test (SDMT) and the Multiple Sclerosis Inventory Cognition (MuSIC), which are standardised against normative data from healthy controls. Cognitive performance was assessed at baseline and at 1-year and 2-year follow-up assessments. Multiple linear regression was used to analyse demographic and clinical predictors of cognitive deficits identified in previous correlation analyses. - Results: At baseline, the study sample of MOGAD patients showed impaired standardised performance on MuSIC semantic fluency (mean=−0.29, 95% CI (−0.47 to −0.12)) and MuSIC congruent speed (mean=−0.73, 95% CI (−1.23 to −0.23)). Around 1 in 10 patients showed deficits in two or more cognitive measures (11%). No decline in cognition was observed during the 1-year and 2-year follow-up period. Cerebral lesions were found to be negatively predictive for SDMT (B=−8.85, 95% CI (−13.57 to −4.14)) and MuSIC semantic fluency (B=−4.17, 95% CI (−6.10 to −2.25)) test performance. - Conclusions: Based on these data, we conclude that MOGAD patients show reduced visuomotor processing speed and semantic fluency to the extent that the disease burden includes cerebral lesions.
Item Description:Gesehen am 18.02.2025
Erstveröffentlichung: 30. Juli 2024
Physical Description:Online Resource
ISSN:1468-330X
DOI:10.1136/jnnp-2024-333994

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