MR enhancement of brain lesions: increased contrast dose compared with magnetization transfer.
PURPOSE To compare image contrast and lesion conspicuity of enhancing intracranial lesions obtained with T1-weighted and magnetization transfer T1-weighted spin-echo sequences after administration of standard (0.1 mmol/kg body weight) and triple doses of gadobutrol. - METHODS Twenty-four patients wi...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 Nov 1996
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| In: |
American journal of neuroradiology
Year: 1996, Volume: 17, Issue: 10, Pages: 1853-1859 |
| ISSN: | 1936-959X |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://www.ajnr.org/content/17/10/1853
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| Author Notes: | M. Knauth, M. Forsting, M. Hartmann, S. Heiland, T. Balzer, K. Sartor |
MARC
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| 245 | 1 | 0 | |a MR enhancement of brain lesions |b increased contrast dose compared with magnetization transfer. |c M. Knauth, M. Forsting, M. Hartmann, S. Heiland, T. Balzer, K. Sartor |
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| 520 | |a PURPOSE To compare image contrast and lesion conspicuity of enhancing intracranial lesions obtained with T1-weighted and magnetization transfer T1-weighted spin-echo sequences after administration of standard (0.1 mmol/kg body weight) and triple doses of gadobutrol. - METHODS Twenty-four patients with a total of 34 enhancing intracranial lesions were studied with T1-weighted and magnetization transfer T1-weighted spin-echo MR imaging. An incremental dose technique was used with intravenous injections of 0.1 and 0.2 mmol/kg body weight gadobutrol. Lesion-to-white matter contrast and white matter-to-edema contrast were calculated. - RESULTS The lesion-to-white matter contrast of the magnetization transfer T1-weighted studies was significantly higher than that of the T1-weighted studies when identical doses of gadobutrol were compared. The lesion-to-white matter contrast was not significantly different on the triple-dose T1-weighted study and the standard-dose magnetization transfer T1-weighted study. Two lesions were visible only on the standard-dose magnetization transfer T1-weighted and the triple-dose studies. - CONCLUSION Standard-dose magnetization transfer T1-weighted and triple-dose T1-weighted spin-echo MR studies are equally well suited to increase the lesion-to-white matter contrast in patients with enhancing intracranial lesions. Triple-dose magnetization transfer T1-weighted studies further increase lesion-to-white matter contrast but do not show additional lesions. | ||
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