Immune landscape of renal cell carcinoma with metastasis to the pancreas
Introduction - Clear cell Renal Cell Carcinoma (ccRCC) has a poor prognosis once metastatic. However, certain metastatic sites have been reported to have a different impact on the patient prognosis. For example, patients with pancreatic metastases have a much more favorable prognosis than those with...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2024
|
| In: |
Urologic oncology
Year: 2024, Volume: 42, Issue: 11, Pages: 373.e9-373.e17 |
| ISSN: | 1873-2496 |
| DOI: | 10.1016/j.urolonc.2024.06.006 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.urolonc.2024.06.006 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1078143924005027 
|
| Author Notes: | Maximilian Kippenberger, Gita Schönberg, Adam Kaczorowski, Felix Schneider, Sarah Böning, Angela Sun, Constantin Schwab, Magdalena Görtz, Viktoria Schütz, Albrecht Stenzinger, Markus Hohenfellner, Anette Duensing, Stefan Duensing |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1917751893 | ||
| 003 | DE-627 | ||
| 005 | 20250716233114.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250221s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.urolonc.2024.06.006 |2 doi | |
| 035 | |a (DE-627)1917751893 | ||
| 035 | |a (DE-599)KXP1917751893 | ||
| 035 | |a (OCoLC)1528019479 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kippenberger, Maximilian |e VerfasserIn |0 (DE-588)1204096996 |0 (DE-627)1689233702 |4 aut | |
| 245 | 1 | 0 | |a Immune landscape of renal cell carcinoma with metastasis to the pancreas |c Maximilian Kippenberger, Gita Schönberg, Adam Kaczorowski, Felix Schneider, Sarah Böning, Angela Sun, Constantin Schwab, Magdalena Görtz, Viktoria Schütz, Albrecht Stenzinger, Markus Hohenfellner, Anette Duensing, Stefan Duensing |
| 264 | 1 | |c November 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar 8 July 2024, Version des Artikels 3 September 2024 | ||
| 500 | |a Gesehen am 21.02.2025 | ||
| 520 | |a Introduction - Clear cell Renal Cell Carcinoma (ccRCC) has a poor prognosis once metastatic. However, certain metastatic sites have been reported to have a different impact on the patient prognosis. For example, patients with pancreatic metastases have a much more favorable prognosis than those with metastases to other organs. The biological basis for this observation remains poorly understood. The aim of this study was to characterize the immune landscape of pancreatic metastases and the corresponding primary tumors in order to identify possible immunological features that correlate with disease biology. - Patients and Methods - A detailed assessment of immune cell populations was performed using a total of 1,700 microscopic images from ccRCCs from 11 patients, their corresponding pancreatic metastases and ccRCCs from 10 patients without pancreatic metastases. Tumor specimens were stained for CD45, CD8, CD163 and FOXP3 and the densities of the respective immune cells were assessed semiquantitatively in the intratumoral and extratumoral compartment. Multispectral imaging was performed in selected tumors. - Results - We found that pancreatic metastases show the lowest intratumoral infiltration with CD8+ cytotoxic T lymphocytes of all tumor specimens analyzed. The frequency of CD8+ lymphocytes was on 1.9 fold lower in pancreatic metastases (median density 8.3 cells per field of view [FOV]=1.23 mm2) when compared to the corresponding primary tumor (15.6 cells per FOV, P=0.0002) and more than 3-fold lower when compared to ccRCCs without pancreatic metastases (27.2 cells per FOV, P=0.0012). There was also a significantly reduced intratumoral infiltration with immunosuppressive FOXP3+ lymphocytes in pancreatic metastases (2.6 cells per FOV, P=0.009) and corresponding primary tumors (2 cells per FOV, P=0.028) when compared to ccRCCs without pancreatic metastases (5.6 cells per FOV). - Conclusions - In this proof-of-concept study, we show that pancreatic metastases of ccRCC present with unique immunological features including a low intratumoral density of CD8+ and FOXP3+ lymphocytes. The low counts of CD8+ and FOXP3+ lymphocytes may reflect less aggressive features of ccRCC with pancreatic metastasis that may result in a more favorable patient prognosis. | ||
| 650 | 4 | |a Clear cell renal cell carcinoma | |
| 650 | 4 | |a Immune landscape | |
| 650 | 4 | |a Pancreatic metastasis | |
| 700 | 1 | |a Schoenberg, Gita |e VerfasserIn |0 (DE-588)105861858X |0 (DE-627)797240357 |0 (DE-576)414774892 |4 aut | |
| 700 | 1 | |a Kaczorowski, Adam |e VerfasserIn |0 (DE-588)1062747550 |0 (DE-627)806827742 |0 (DE-576)420146318 |4 aut | |
| 700 | 1 | |a Schneider, Felix |e VerfasserIn |0 (DE-588)1261900014 |0 (DE-627)180928953X |4 aut | |
| 700 | 1 | |a Böning, Sarah |e VerfasserIn |0 (DE-588)1357106513 |0 (DE-627)191775468X |4 aut | |
| 700 | 1 | |a Sun, Angela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwab, Constantin |d 1992- |e VerfasserIn |0 (DE-588)1106892291 |0 (DE-627)863243045 |0 (DE-576)474954269 |4 aut | |
| 700 | 1 | |a Görtz, Magdalena |d 1992- |e VerfasserIn |0 (DE-588)1166813657 |0 (DE-627)1030681392 |0 (DE-576)510916600 |4 aut | |
| 700 | 1 | |a Schütz, Viktoria |e VerfasserIn |0 (DE-588)1183860021 |0 (DE-627)1663385335 |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 700 | 1 | |a Hohenfellner, Markus |d 1958- |e VerfasserIn |0 (DE-588)133862518 |0 (DE-627)557857988 |0 (DE-576)300155263 |4 aut | |
| 700 | 1 | |a Duensing, Anette |e VerfasserIn |0 (DE-588)1186091703 |0 (DE-627)1665366486 |4 aut | |
| 700 | 1 | |a Duensing, Stefan |d 1967- |e VerfasserIn |0 (DE-588)1074044487 |0 (DE-627)830213007 |0 (DE-576)435550098 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Urologic oncology |d Amsterdam [u.a.] : Elsevier Science, 1995 |g 42(2024), 11 vom: Nov., Seite 373.e9-373.e17 |h Online-Ressource |w (DE-627)320491021 |w (DE-600)2011021-2 |w (DE-576)272349585 |x 1873-2496 |7 nnas |a Immune landscape of renal cell carcinoma with metastasis to the pancreas |
| 773 | 1 | 8 | |g volume:42 |g year:2024 |g number:11 |g month:11 |g pages:373.e9-373.e17 |g extent:9 |a Immune landscape of renal cell carcinoma with metastasis to the pancreas |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.urolonc.2024.06.006 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1078143924005027 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250221 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1074044487 |a Duensing, Stefan |m 1074044487:Duensing, Stefan |d 910000 |d 910200 |d 50000 |e 910000PD1074044487 |e 910200PD1074044487 |e 50000PD1074044487 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 13 |y j | ||
| 998 | |g 1186091703 |a Duensing, Anette |m 1186091703:Duensing, Anette |d 910000 |d 910200 |d 50000 |e 910000PD1186091703 |e 910200PD1186091703 |e 50000PD1186091703 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 12 | ||
| 998 | |g 133862518 |a Hohenfellner, Markus |m 133862518:Hohenfellner, Markus |d 910000 |d 910200 |d 50000 |e 910000PH133862518 |e 910200PH133862518 |e 50000PH133862518 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 11 | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |d 50000 |e 910000PS139606106 |e 912000PS139606106 |e 50000PS139606106 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 10 | ||
| 998 | |g 1183860021 |a Schütz, Viktoria |m 1183860021:Schütz, Viktoria |d 910000 |d 910200 |d 50000 |e 910000PS1183860021 |e 910200PS1183860021 |e 50000PS1183860021 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 9 | ||
| 998 | |g 1166813657 |a Görtz, Magdalena |m 1166813657:Görtz, Magdalena |d 910000 |d 910200 |d 50000 |e 910000PG1166813657 |e 910200PG1166813657 |e 50000PG1166813657 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 | ||
| 998 | |g 1106892291 |a Schwab, Constantin |m 1106892291:Schwab, Constantin |d 910000 |d 912000 |d 50000 |e 910000PS1106892291 |e 912000PS1106892291 |e 50000PS1106892291 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 7 | ||
| 998 | |g 1357106513 |a Böning, Sarah |m 1357106513:Böning, Sarah |d 910000 |d 910200 |e 910000PB1357106513 |e 910200PB1357106513 |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 1261900014 |a Schneider, Felix |m 1261900014:Schneider, Felix |p 4 | ||
| 998 | |g 1062747550 |a Kaczorowski, Adam |m 1062747550:Kaczorowski, Adam |d 910000 |d 910200 |e 910000PK1062747550 |e 910200PK1062747550 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 105861858X |a Schoenberg, Gita |m 105861858X:Schoenberg, Gita |d 910000 |d 910200 |e 910000PS105861858X |e 910200PS105861858X |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 1204096996 |a Kippenberger, Maximilian |m 1204096996:Kippenberger, Maximilian |d 50000 |e 50000PK1204096996 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1917751893 |e 4668500054 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Immune landscape of renal cell carcinoma with metastasis to the pancreas","title":"Immune landscape of renal cell carcinoma with metastasis to the pancreas"}],"person":[{"family":"Kippenberger","given":"Maximilian","display":"Kippenberger, Maximilian","role":"aut"},{"given":"Gita","display":"Schoenberg, Gita","family":"Schoenberg","role":"aut"},{"given":"Adam","display":"Kaczorowski, Adam","family":"Kaczorowski","role":"aut"},{"role":"aut","family":"Schneider","display":"Schneider, Felix","given":"Felix"},{"family":"Böning","display":"Böning, Sarah","given":"Sarah","role":"aut"},{"role":"aut","given":"Angela","display":"Sun, Angela","family":"Sun"},{"family":"Schwab","given":"Constantin","display":"Schwab, Constantin","role":"aut"},{"role":"aut","family":"Görtz","display":"Görtz, Magdalena","given":"Magdalena"},{"family":"Schütz","given":"Viktoria","display":"Schütz, Viktoria","role":"aut"},{"family":"Stenzinger","display":"Stenzinger, Albrecht","given":"Albrecht","role":"aut"},{"family":"Hohenfellner","given":"Markus","display":"Hohenfellner, Markus","role":"aut"},{"role":"aut","family":"Duensing","display":"Duensing, Anette","given":"Anette"},{"role":"aut","display":"Duensing, Stefan","given":"Stefan","family":"Duensing"}],"recId":"1917751893","origin":[{"dateIssuedDisp":"November 2024","dateIssuedKey":"2024"}],"name":{"displayForm":["Maximilian Kippenberger, Gita Schönberg, Adam Kaczorowski, Felix Schneider, Sarah Böning, Angela Sun, Constantin Schwab, Magdalena Görtz, Viktoria Schütz, Albrecht Stenzinger, Markus Hohenfellner, Anette Duensing, Stefan Duensing"]},"relHost":[{"recId":"320491021","disp":"Immune landscape of renal cell carcinoma with metastasis to the pancreasUrologic oncology","language":["eng"],"pubHistory":["1.1995 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1995","dateIssuedDisp":"1995-","publisher":"Elsevier Science"}],"title":[{"title":"Urologic oncology","title_sort":"Urologic oncology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2011021-2"],"issn":["1873-2496"],"eki":["320491021"]},"part":{"year":"2024","pages":"373.e9-373.e17","volume":"42","text":"42(2024), 11 vom: Nov., Seite 373.e9-373.e17","extent":"9","issue":"11"},"note":["Gesehen am 22.11.04"]}],"note":["Online verfügbar 8 July 2024, Version des Artikels 3 September 2024","Gesehen am 21.02.2025"],"physDesc":[{"extent":"9 S.","noteIll":"Illustrationen"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.urolonc.2024.06.006"],"eki":["1917751893"]}} | ||
| SRT | |a KIPPENBERGIMMUNELAND2024 | ||