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The IPTA Nashville consensus conference on post-transplant lymphoproliferative disorders after solid organ transplantation in children: IV-consensus guidelines for the management of post-transplant lymphoproliferative disorders in children and adolescents

The International Pediatric Transplant Association convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorders (PTLD) after pediatric solid organ transplantation. This report addr...

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Main Authors: Allen, Upton (Author) , L'Huillier, Arnaud G. (Author) , Bollard, Catherine M. (Author) , Gross, Thomas G. (Author) , Hayashi, Robert J. (Author) , Höcker, Britta (Author) , Maecker-Kolhoff, Britta (Author) , Marks, Stephen D. (Author) , Mazariegos, George Vincent (Author) , Smets, Francoise (Author) , Trappe, Ralf U. (Author) , Visner, Gary (Author) , Chinnock, Richard E. (Author) , Comoli, Patrizia (Author) , Danziger-Isakov, Lara (Author) , Dulek, Daniel E. (Author) , Dipchand, Anne I. (Author) , Ferry, Judith A. (Author) , Martinez, Olivia M. (Author) , Metes, Diana M. (Author) , Michaels, Marian G. (Author) , Preiksaitis, Jutta (Author) , Squires, James E. (Author) , Swerdlow, Steven H. (Author) , Wilkinson, James D. (Author) , Dharnidharka, Vikas R. (Author) , Green, Michael (Author) , Webber, Steven A. (Author) , Esquivel, Carlos O. (Author)
Format: Article (Journal)
Language:English
Published: August 2024
In: Pediatric transplantation
Year: 2024, Volume: 28, Issue: 5, Pages: i14781$p1-20
ISSN:1399-3046
DOI:10.1111/petr.14781
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/petr.14781
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.14781
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Author Notes:Upton D. Allen, Arnaud G. L'Huillier, Catherine M. Bollard, Thomas G. Gross, Robert J. Hayashi, Britta Höcker, Britta Maecker-Kolhoff, Stephen D. Marks, George Vincent Mazariegos, Francoise Smets, Ralf U. Trappe, Gary Visner, Richard E. Chinnock, Patrizia Comoli, Lara Danziger-Isakov, Daniel E. Dulek, Anne I. Dipchand, Judith A. Ferry, Olivia M. Martinez, Diana M. Metes, Marian G. Michaels, Jutta Preiksaitis, James E. Squires, Steven H. Swerdlow, James D. Wilkinson, Vikas R. Dharnidharka, Michael Green, Steven A. Webber, Carlos O. Esquivel
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Summary:The International Pediatric Transplant Association convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorders (PTLD) after pediatric solid organ transplantation. This report addresses the outcomes of deliberations by the PTLD Management Working Group. A strong recommendation was made for reduction in immunosuppression as the first step in management. Similarly, strong recommendations were made for the use of the anti-CD20 monoclonal antibody (rituximab) as was the case for chemotherapy in selected scenarios. In some scenarios, there is uncoupling of the strength of the recommendations from the available evidence in situations where such evidence is lacking but collective clinical experiences drive decision-making. Of note, there are no large, randomized phase III trials of any treatment for PTLD in the pediatric age group. Current gaps and future research priorities are highlighted.
Item Description:Gesehen am 21.02.2025
Physical Description:Online Resource
ISSN:1399-3046
DOI:10.1111/petr.14781

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