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The impact of postoperative aspirin in patients undergoing Woven EndoBridge: a multicenter, institutional, propensity score-matched analysis

Background The Woven EndoBridge (WEB) device is frequently used for the treatment of intracranial aneurysms. Postoperative management, including the use of aspirin, varies among clinicians and institutions, but its impact on the outcomes of the WEB has not been thoroughly investigated. - Methods Thi...

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Main Authors: Dmytriw, Adam A. (Author) , Musmar, Basel (Author) , Salim, Hamza (Author) , Aslan, Assala (Author) , Cancelliere, Nicole M. (Author) , McLellan, Rachel M. (Author) , Algin, Oktay (Author) , Ghozy, Sherief (Author) , Dibas, Mahmoud (Author) , Lay, Sovann V. (Author) , Guenego, Adrien (Author) , Renieri, Leonardo (Author) , Carnevale, Joseph Anthony (Author) , Saliou, Guillaume (Author) , Mastorakos, Panagiotis (Author) , Naamani, Kareem El (Author) , Shotar, Eimad (Author) , Premat, Kevin (Author) , Möhlenbruch, Markus Alfred (Author) , Kral, Michael (Author) , Doron, Omer (Author) , Chung, Charlotte (Author) , Salem, Mohamed M . (Author) , Lylyk, Ivan (Author) , Foreman, Paul M. (Author) , Vachhani, Jay A. (Author) , Shaikh, Hamza (Author) , Župančić, Vedran (Author) , Hafeez, Muhammad Ubaid (Author) , Catapano, Joshua S. (Author) , Waqas, Muhammad (Author) , Tutino, Vincent M. (Author) , Ibrahim, Mohamed K. (Author) , Mohammed, Marwa A. (Author) , Imamoglu, Cetin (Author) , Bayrak, Ahmet (Author) , Rabinov, James D. (Author) , Ren, Yifan (Author) , Schirmer, Clemens M. (Author) , Piano, Mariangela (Author) , Kühn, Anna Luisa (Author) , Michelozzi, Caterina (Author) , Elens, Stephanie (Author) , Zuha Rosufila Abu Hasan (Author) , Starke, Robert M. (Author) , Hassan, Ameer E. (Author) , Ogilvie, Mark (Author) , Nguyen, Anh (Author) , Jones, Jesse (Author) , Brinjikji, Waleed (Author) , Nawka, Marie Teresa (Author) , Psychogios, Marios-Nikos (Author) , Ulfert, Christian (Author) , Diestro, Jose Danilo Bengzon (Author) , Pukenas, Bryan (Author) , Burkhardt, Jan-Karl (Author) , Huynh, Thien J. (Author) , Martinez-Gutierrez, Juan Carlos (Author) , Essibayi, Muhammed Amir (Author) , Sheth, Sunil A. (Author) , Spiegel, Gary (Author) , Tawk, Rabih (Author) , Lubicz, Boris (Author) , Panni, Pietro (Author) , Puri, Ajit S. (Author) , Pero, Guglielmo (Author) , Nossek, Erez (Author) , Raz, Eytan (Author) , Killer-Oberpfalzer, Monika (Author) , Griessenauer, Christoph J. (Author) , Asadi, Hamed (Author) , Siddiqui, Adnan H. (Author) , Brook, Allan L. (Author) , Altschul, David (Author) , Ducruet, Andrew F. (Author) , Albuquerque, Felipe C. (Author) , Regenhardt, Robert W. (Author) , Stapleton, Christopher J. (Author) , Kan, Peter (Author) , Kalousek, Vladimir (Author) , Lylyk, Pedro (Author) , Boddu, Srikanth Reddy (Author) , Knopman, Jared (Author) , Aziz-Sultan, Mohammad A. (Author) , Tjoumakaris, Stavropoula I. (Author) , Clarençon, Frédéric (Author) , Limbucci, Nicola (Author) , Cuellar, Hugo H. (Author) , Jabbour, Pascal M. (Author) , Pereira, Vitor Mendes (Author) , Patel, Aman B. (Author) , Adeeb, Nimer (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Journal of neuroInterventional surgery
Year: 2025, Volume: 17, Issue: e1, Pages: e15-e24
ISSN:1759-8486
DOI:10.1136/jnis-2023-021082
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jnis-2023-021082
Verlag, lizenzpflichtig, Volltext: https://jnis.bmj.com/content/17/e1/e15
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Author Notes:Adam A. Dmytriw, Basel Musmar, Hamza Salim, Assala Aslan, Nicole M. Cancelliere, Rachel M. McLellan, Oktay Algin, Sherief Ghozy, Mahmoud Dibas, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Joseph Anthony Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Kevin Premat, Markus A. Möhlenbruch, Michael Kral, Omer Doron, Charlotte Chung, Mohamed M. Salem, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Hamza Shaikh, Vedran Župančić, Muhammad Ubaid Hafeez, Joshua S. Catapano, Muhammad Waqas, Vincent M. Tutino, Mohamed K. Ibrahim, Marwa A. Mohammed, Cetin Imamoglu, Ahmet Bayrak, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna Luisa Kuhn, Caterina Michelozzi, Stephanie Elens, Zuha Hasan, Robert M. Starke, Ameer E. Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie Teresa Nawka, Marios-Nikos Psychogios, Christian Ulfert, Jose Danilo Bengzon Diestro, Bryan Pukenas, Jan Karl Burkhardt, Thien J. Huynh, Juan Carlos Martinez-Gutierrez, Muhammed Amir Essibayi, Sunil A. Sheth, Gary Spiegel, Rabih Tawk, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Erez Nossek, Eytan Raz, Monika Killer-Oberpfalzer, Christoph J. Griessenauer, Hamed Asadi, Adnan H. Siddiqui, Allan L. Brook, David Altschul, Andrew F. Ducruet, Felipe C. Albuquerque, Robert W. Regenhardt, Christopher J. Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Reddy Boddu, Jared Knopman, Mohammad A. Aziz-Sultan, Stavropoula I. Tjoumakaris, Frédéric Clarençon, Nicola Limbucci, Hugo H. Cuellar, Pascal M. Jabbour, Vitor M. Pereira, Aman B. Patel, Nimer Adeeb
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Summary:Background The Woven EndoBridge (WEB) device is frequently used for the treatment of intracranial aneurysms. Postoperative management, including the use of aspirin, varies among clinicians and institutions, but its impact on the outcomes of the WEB has not been thoroughly investigated. - Methods This was a retrospective, multicenter study involving 30 academic institutions in North America, South America, and Europe. Data from 1492 patients treated with the WEB device were included. Patients were categorized into two groups based on their postoperative use of aspirin (aspirin group: n=1124, non-aspirin group: n=368). Data points included patient demographics, aneurysm characteristics, procedural details, complications, and angiographic and functional outcomes. Propensity score matching (PSM) was applied to balance variables between the two groups. - Results Prior to PSM, the aspirin group exhibited significantly higher rates of modified Rankin scale (mRS) mRS 0-1 and mRS 0-2 (89.8% vs 73.4% and 94.1% vs 79.8%, p<0.001), lower rates of mortality (1.6% vs 8.6%, p<0.001), and higher major compaction rates (13.4% vs 7%, p<0.001). Post-PSM, the aspirin group showed significantly higher rates of retreatment (p=0.026) and major compaction (p=0.037) while maintaining its higher rates of good functional outcomes and lower mortality rates. In the multivariable regression, aspirin was associated with higher rates of mRS 0-1 (OR 2.166; 95% CI 1.16 to 4, p=0.016) and mRS 0-2 (OR 2.817; 95% CI 1.36 to 5.88, p=0.005) and lower rates of mortality (OR 0.228; 95% CI 0.06 to 0.83, p=0.025). However, it was associated with higher rates of retreatment (OR 2.471; 95% CI 1.11 to 5.51, p=0.027). - Conclusions Aspirin use post-WEB treatment may lead to better functional outcomes and lower mortality but with higher retreatment rates. These insights are crucial for postoperative management after WEB procedures, but further studies are necessary for validation.
Item Description:Gesehen am 21.02.2025
Published online first: 18 January 2024
Physical Description:Online Resource
ISSN:1759-8486
DOI:10.1136/jnis-2023-021082

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