Cover Image

Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years

Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large B-cell lymphoma (DLBCL), although their roles are challenged by CAR-T-cells and other immunotherapies. We examined the transplantation trends and outcomes f...

Full description

Saved in:
Bibliographic Details
Main Authors: Berning, Philipp (Author) , Fekom, Mathilde (Author) , Ngoya, Maud (Author) , Goldstone, Anthony H. (Author) , Dreger, Peter (Author) , Montoto, Silvia (Author) , Finel, Hervé (Author) , Shumilov, Evgenii (Author) , Chevallier, Patrice (Author) , Blaise, Didier (Author) , Strüßmann, Tim (Author) , Carpenter, Ben (Author) , Forcade, Edouard (Author) , Castilla-Llorente, Cristina (Author) , Trneny, Marek (Author) , Ghesquieres, Hervé (Author) , Capria, Saveria (Author) , Thieblemont, Catherine (Author) , Blau, Igor-Wolfgang (Author) , Meijer, Ellen (Author) , Broers, Annoek E. C. (Author) , Huynh, Anne (Author) , Caillot, Denis (Author) , Rösler, Wolf (Author) , Nguyen Quoc, Stephanie (Author) , Bittenbring, Jörg (Author) , Nagler, Arnon (Author) , Galimard, Jacques-Emmanuel (Author) , Glass, Bertram (Author) , Sureda, Anna (Author) , Schmitz, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 05 July 2024
In: Blood cancer journal
Year: 2024, Volume: 14, Pages: 1-13
ISSN:2044-5385
DOI:10.1038/s41408-024-01085-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41408-024-01085-9
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41408-024-01085-9
Get full text
Author Notes:Philipp Berning, Mathilde Fekom, Maud Ngoya, Anthony H. Goldstone, Peter Dreger, Silvia Montoto, Hervé Finel, Evgenii Shumilov, Patrice Chevallier, Didier Blaise, Tim Strüssmann, Ben Carpenter, Edouard Forcade, Cristina Castilla-Llorente, Marek Trneny, Hervé Ghesquieres, Saveria Capria, Catherine Thieblemont, Igor Wolfgang Blau, Ellen Meijer, Annoek E. C. Broers, Anne Huynh, Denis Caillot, Wolf Rösler, Stephanie Nguyen Quoc, Jörg Bittenbring, Arnon Nagler, Jacques-Emmanuel Galimard, Bertram Glass, Anna Sureda and Norbert Schmitz

MARC

LEADER 00000caa a2200000 c 4500
001 1918709920
003 DE-627
005 20250716234359.0
007 cr uuu---uuuuu
008 250227s2024 xx |||||o 00| ||eng c
024 7 |a 10.1038/s41408-024-01085-9  |2 doi 
035 |a (DE-627)1918709920 
035 |a (DE-599)KXP1918709920 
035 |a (OCoLC)1528019812 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Berning, Philipp  |d 1990-  |e VerfasserIn  |0 (DE-588)112860325X  |0 (DE-627)882975013  |0 (DE-576)485935600  |4 aut 
245 1 0 |a Hematopoietic stem cell transplantation for DLBCL  |b a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years  |c Philipp Berning, Mathilde Fekom, Maud Ngoya, Anthony H. Goldstone, Peter Dreger, Silvia Montoto, Hervé Finel, Evgenii Shumilov, Patrice Chevallier, Didier Blaise, Tim Strüssmann, Ben Carpenter, Edouard Forcade, Cristina Castilla-Llorente, Marek Trneny, Hervé Ghesquieres, Saveria Capria, Catherine Thieblemont, Igor Wolfgang Blau, Ellen Meijer, Annoek E. C. Broers, Anne Huynh, Denis Caillot, Wolf Rösler, Stephanie Nguyen Quoc, Jörg Bittenbring, Arnon Nagler, Jacques-Emmanuel Galimard, Bertram Glass, Anna Sureda and Norbert Schmitz 
264 1 |c 05 July 2024 
300 |b Illustrationen 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 27.02.2025 
520 |a Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large B-cell lymphoma (DLBCL), although their roles are challenged by CAR-T-cells and other immunotherapies. We examined the transplantation trends and outcomes for DLBCL patients undergoing auto-/allo-HSCT between 1990 and 2021 reported to EBMT. Over this period, 41,148 patients underwent auto-HSCT, peaking at 1911 cases in 2016, while allo-HSCT saw a maximum of 294 cases in 2018. The recent decline in transplants corresponds to increased CAR-T treatments (1117 cases in 2021). Median age for auto-HSCT rose from 42 (1990-1994) to 58 years (2015-2021), with peripheral blood becoming the primary stem cell source post-1994. Allo-HSCT median age increased from 36 (1990-1994) to 54 (2015-2021) years, with mobilized blood as the primary source post-1998 and reduced intensity conditioning post-2000. Unrelated and mismatched allo-HSCT accounted for 50% and 19% of allo-HSCT in 2015-2021. Three-year overall survival (OS) after auto-HSCT improved from 56% (1990-1994) to 70% (2015-2021), p < 0.001, with a decrease in relapse incidence (RI) from 49% to 38%, while non-relapse mortality (NRM) remained unchanged (4%). After allo-HSCT, 3-year-OS increased from 33% (1990-1999) to 46% (2015-2021) (p < 0.001); 3-year RI remained at 39% and 1-year-NRM decreased to 19% (p < 0.001). Our data reflect advancements over 32 years and >40,000 transplants, providing insights for evaluating emerging DLBCL therapies. 
650 4 |a B-cell lymphoma 
650 4 |a Disease-free survival 
700 1 |a Fekom, Mathilde  |e VerfasserIn  |4 aut 
700 1 |a Ngoya, Maud  |e VerfasserIn  |4 aut 
700 1 |a Goldstone, Anthony H.  |e VerfasserIn  |4 aut 
700 1 |a Dreger, Peter  |e VerfasserIn  |0 (DE-588)1028891881  |0 (DE-627)732699894  |0 (DE-576)376320966  |4 aut 
700 1 |a Montoto, Silvia  |e VerfasserIn  |4 aut 
700 1 |a Finel, Hervé  |e VerfasserIn  |4 aut 
700 1 |a Shumilov, Evgenii  |e VerfasserIn  |4 aut 
700 1 |a Chevallier, Patrice  |e VerfasserIn  |4 aut 
700 1 |a Blaise, Didier  |e VerfasserIn  |4 aut 
700 1 |8 1\p  |a Strüßmann, Tim  |e VerfasserIn  |0 (DE-588)1047819260  |0 (DE-627)779257227  |0 (DE-576)401632091  |4 aut 
700 1 |a Carpenter, Ben  |e VerfasserIn  |4 aut 
700 1 |a Forcade, Edouard  |e VerfasserIn  |4 aut 
700 1 |a Castilla-Llorente, Cristina  |e VerfasserIn  |4 aut 
700 1 |a Trneny, Marek  |e VerfasserIn  |4 aut 
700 1 |a Ghesquieres, Hervé  |e VerfasserIn  |4 aut 
700 1 |a Capria, Saveria  |e VerfasserIn  |4 aut 
700 1 |a Thieblemont, Catherine  |e VerfasserIn  |4 aut 
700 1 |a Blau, Igor-Wolfgang  |d 1960-  |e VerfasserIn  |0 (DE-588)111826438  |0 (DE-627)566073560  |0 (DE-576)289713366  |4 aut 
700 1 |a Meijer, Ellen  |e VerfasserIn  |4 aut 
700 1 |a Broers, Annoek E. C.  |e VerfasserIn  |4 aut 
700 1 |a Huynh, Anne  |e VerfasserIn  |4 aut 
700 1 |a Caillot, Denis  |e VerfasserIn  |4 aut 
700 1 |a Rösler, Wolf  |e VerfasserIn  |4 aut 
700 1 |a Nguyen Quoc, Stephanie  |e VerfasserIn  |4 aut 
700 1 |a Bittenbring, Jörg  |e VerfasserIn  |4 aut 
700 1 |a Nagler, Arnon  |e VerfasserIn  |4 aut 
700 1 |a Galimard, Jacques-Emmanuel  |e VerfasserIn  |4 aut 
700 1 |a Glass, Bertram  |e VerfasserIn  |4 aut 
700 1 |8 2\p  |a Sureda, Anna  |e VerfasserIn  |0 (DE-588)116142993X  |0 (DE-627)1024721876  |0 (DE-576)506512037  |4 aut 
700 1 |a Schmitz, Norbert  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Blood cancer journal  |d [London] : Springer Nature, 2011  |g 14(2024), Artikel-ID 106, Seite 1-13  |h Online-Ressource  |w (DE-627)655134174  |w (DE-600)2600560-8  |w (DE-576)339571802  |x 2044-5385  |7 nnas  |a Hematopoietic stem cell transplantation for DLBCL a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years 
773 1 8 |g volume:14  |g year:2024  |g elocationid:106  |g pages:1-13  |g extent:13  |a Hematopoietic stem cell transplantation for DLBCL a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years 
856 4 0 |u https://doi.org/10.1038/s41408-024-01085-9  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s41408-024-01085-9  |x Verlag  |z kostenfrei  |3 Volltext 
883 |8 1\p  |a cgwrk  |d 20250301  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
883 |8 2\p  |a cgwrk  |d 20250301  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
951 |a AR 
992 |a 20250227 
993 |a Article 
994 |a 2024 
998 |g 1028891881  |a Dreger, Peter  |m 1028891881:Dreger, Peter  |d 910000  |d 910100  |e 910000PD1028891881  |e 910100PD1028891881  |k 0/910000/  |k 1/910000/910100/  |p 5 
999 |a KXP-PPN1918709920  |e 4674260108 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title":"Hematopoietic stem cell transplantation for DLBCL","subtitle":"a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years","title_sort":"Hematopoietic stem cell transplantation for DLBCL"}],"note":["Gesehen am 27.02.2025"],"relHost":[{"part":{"year":"2024","text":"14(2024), Artikel-ID 106, Seite 1-13","volume":"14","extent":"13","pages":"1-13"},"language":["eng"],"title":[{"title_sort":"Blood cancer journal","title":"Blood cancer journal"}],"pubHistory":["1.2011-"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedDisp":"2017-","publisher":"Springer Nature ; Nature Publ. Group","dateIssuedKey":"2017","publisherPlace":"[London] ; London [u.a.]"}],"recId":"655134174","note":["Gesehen am 17.07.24"],"disp":"Hematopoietic stem cell transplantation for DLBCL a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 yearsBlood cancer journal","physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2600560-8"],"issn":["2044-5385"],"eki":["655134174"]}}],"id":{"doi":["10.1038/s41408-024-01085-9"],"eki":["1918709920"]},"physDesc":[{"noteIll":"Illustrationen","extent":"13 S."}],"origin":[{"dateIssuedDisp":"05 July 2024","dateIssuedKey":"2024"}],"recId":"1918709920","type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Philipp","role":"aut","display":"Berning, Philipp","family":"Berning"},{"family":"Fekom","given":"Mathilde","role":"aut","display":"Fekom, Mathilde"},{"role":"aut","given":"Maud","display":"Ngoya, Maud","family":"Ngoya"},{"family":"Goldstone","given":"Anthony H.","role":"aut","display":"Goldstone, Anthony H."},{"family":"Dreger","display":"Dreger, Peter","given":"Peter","role":"aut"},{"family":"Montoto","display":"Montoto, Silvia","role":"aut","given":"Silvia"},{"given":"Hervé","role":"aut","display":"Finel, Hervé","family":"Finel"},{"family":"Shumilov","given":"Evgenii","role":"aut","display":"Shumilov, Evgenii"},{"family":"Chevallier","display":"Chevallier, Patrice","role":"aut","given":"Patrice"},{"display":"Blaise, Didier","role":"aut","given":"Didier","family":"Blaise"},{"display":"Strüßmann, Tim","given":"Tim","role":"aut","family":"Strüßmann"},{"family":"Carpenter","display":"Carpenter, Ben","given":"Ben","role":"aut"},{"given":"Edouard","role":"aut","display":"Forcade, Edouard","family":"Forcade"},{"family":"Castilla-Llorente","display":"Castilla-Llorente, Cristina","given":"Cristina","role":"aut"},{"role":"aut","given":"Marek","display":"Trneny, Marek","family":"Trneny"},{"family":"Ghesquieres","display":"Ghesquieres, Hervé","role":"aut","given":"Hervé"},{"family":"Capria","display":"Capria, Saveria","role":"aut","given":"Saveria"},{"family":"Thieblemont","display":"Thieblemont, Catherine","role":"aut","given":"Catherine"},{"family":"Blau","role":"aut","given":"Igor-Wolfgang","display":"Blau, Igor-Wolfgang"},{"family":"Meijer","display":"Meijer, Ellen","role":"aut","given":"Ellen"},{"given":"Annoek E. C.","role":"aut","display":"Broers, Annoek E. C.","family":"Broers"},{"family":"Huynh","role":"aut","given":"Anne","display":"Huynh, Anne"},{"family":"Caillot","display":"Caillot, Denis","role":"aut","given":"Denis"},{"family":"Rösler","display":"Rösler, Wolf","given":"Wolf","role":"aut"},{"given":"Stephanie","role":"aut","display":"Nguyen Quoc, Stephanie","family":"Nguyen Quoc"},{"display":"Bittenbring, Jörg","given":"Jörg","role":"aut","family":"Bittenbring"},{"display":"Nagler, Arnon","given":"Arnon","role":"aut","family":"Nagler"},{"display":"Galimard, Jacques-Emmanuel","given":"Jacques-Emmanuel","role":"aut","family":"Galimard"},{"display":"Glass, Bertram","role":"aut","given":"Bertram","family":"Glass"},{"role":"aut","given":"Anna","display":"Sureda, Anna","family":"Sureda"},{"family":"Schmitz","given":"Norbert","role":"aut","display":"Schmitz, Norbert"}],"name":{"displayForm":["Philipp Berning, Mathilde Fekom, Maud Ngoya, Anthony H. Goldstone, Peter Dreger, Silvia Montoto, Hervé Finel, Evgenii Shumilov, Patrice Chevallier, Didier Blaise, Tim Strüssmann, Ben Carpenter, Edouard Forcade, Cristina Castilla-Llorente, Marek Trneny, Hervé Ghesquieres, Saveria Capria, Catherine Thieblemont, Igor Wolfgang Blau, Ellen Meijer, Annoek E. C. Broers, Anne Huynh, Denis Caillot, Wolf Rösler, Stephanie Nguyen Quoc, Jörg Bittenbring, Arnon Nagler, Jacques-Emmanuel Galimard, Bertram Glass, Anna Sureda and Norbert Schmitz"]}} 
SRT |a BERNINGPHIHEMATOPOIE0520 

Similar Items